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A9VA99 (A9VA99_MONBE) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Histone-lysine N-methyltransferase, H3 lysine-79 specific RuleBase RU271113

EC=2.1.1.43 RuleBase RU271113
Alternative name(s):
Histone H3-K79 methyltransferase RuleBase RU271113
Gene names
ORF Names:34214 EMBL EDQ85503.1
OrganismMonosiga brevicollis (Choanoflagellate) [Reference proteome]
Taxonomic identifier81824 [NCBI]
Taxonomic lineageEukaryotaChoanoflagellidaCodonosigidaeMonosiga

Protein attributes

Sequence length919 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone]. RuleBase RU271113

Subcellular location

Nucleus By similarity RuleBase RU271113.

Miscellaneous

In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones By similarity. RuleBase RU271113

Sequence similarities

Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family. RuleBase RU271113

Contains 1 DOT1 domain. RuleBase RU271113

Ontologies

Sequences

Sequence LengthMass (Da)Tools
A9VA99 [UniParc].

Last modified February 5, 2008. Version 1.
Checksum: 529CA3D95C972687

FASTA91999,082
        10         20         30         40         50         60 
MAASAEAEVS QSKPSPLKDQ AGPVQPRPAG LTPGNPVQAV VEEAASPCAS SPQAPSSAPN 

        70         80         90        100        110        120 
SHRRPVGGRI GRVHLGQPGR RVPDEEDVEA IPGGSRELGI TEDWFDVPPL FPPVDTTQTH 

       130        140        150        160        170        180 
LAILSPNPKG PPMLYQWPFT HMTDSSYDAG FELLNSMNHI VKLCALPVPD TWADDIVACA 

       190        200        210        220        230        240 
KPGTEFASLS KVVEAFNAAM RVYHKSVGEQ AERLICPTDL CEHIMNMTYS RAVTDPALLN 

       250        260        270        280        290        300 
RYKGWTAEVY GEFTSKMISD VIANSNVQPD DTFVDLGSGV GQVVLQVALE GRARTSFGIE 

       310        320        330        340        350        360 
KQDIPAEYAK CGAYELVKDN FLQPQYAERI TNTSVVFLNN FAFGTKVNQQ LCRMFENCQA 

       370        380        390        400        410        420 
GTRLISSISL RKSDFTITAR TLNDLGCILT MRKLCYRGQG VSWTARPFSY YVQTVNHQYL 

       430        440        450        460        470        480 
DQFFSKGEPV QVPFENEVGD DDDDANPDRT GTSHSGAPVR DNSDDEEDND EEAEDQSAGA 

       490        500        510        520        530        540 
AGHHKTDAVG KGHSGAERDG KAAAGTRPGS TKRSKGASRR RDRQSSQQSS APPSSSSGKV 

       550        560        570        580        590        600 
AAGDDSASQR LVRTLTRAVA GLERRYPSGR TLRAARHQLR ALHQERSVLR QHRREYEQQL 

       610        620        630        640        650        660 
QQHNQTVAAA LTQRRQQLNE SLGLDSKTDT RLTAAAAGLL HTFVCRGGQS ATSSAANAQQ 

       670        680        690        700        710        720 
SVEHIRLWTK PLQQAQAVHE RLIAALRMHG QAPVADALQR TPWALPRDLC ASNEHSPTRA 

       730        740        750        760        770        780 
TNGHVPVQEA SAGKAGPTGP HQSARRSSDQ NGSASSQVQS AQTRGLEATP DRYAGPLSSA 

       790        800        810        820        830        840 
ETSPASTSSH SAGKRDLSGQ REATNGTEHT SQAQIAGRRE SSSTGTSPTS SLAKLLGAEP 

       850        860        870        880        890        900 
SHRSGHRQGQ QRPIARAREM RPPGGARPGL SSSSKRPLSS NGEPAPQVPD PKRTKDLENA 

       910 
SSDNALERKQ KCHGPETSN 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH991573 Genomic DNA. Translation: EDQ85503.1.
RefSeqXP_001749694.1. XM_001749642.1.

3D structure databases

ProteinModelPortalA9VA99.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING81824.JGI34214.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5894943.
KEGGmbr:MONBRDRAFT_34214.

Phylogenomic databases

eggNOGNOG294902.
KOK11427.

Family and domain databases

InterProIPR013110. DOT1.
IPR025789. Histone_H3-K79_MeTrfase.
[Graphical view]
PfamPF08123. DOT1. 1 hit.
[Graphical view]
PROSITEPS51569. DOT1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA9VA99_MONBE
AccessionPrimary (citable) accession number: A9VA99
Entry history
Integrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: April 16, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)