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Protein

Histone-lysine N-methyltransferase, H3 lysine-79 specific

Gene

34214

Organism
Monosiga brevicollis (Choanoflagellate)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].UniRule annotation

GO - Molecular functioni

  1. histone methyltransferase activity (H3-K79 specific) Source: InterPro

GO - Biological processi

  1. regulation of cell cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulatorUniRule annotation, MethyltransferaseUniRule annotation, Transferase

Keywords - Ligandi

S-adenosyl-L-methionineUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-79 specificUniRule annotation (EC:2.1.1.43UniRule annotation)
Alternative name(s):
Histone H3-K79 methyltransferaseUniRule annotation
Gene namesi
ORF Names:34214Imported
OrganismiMonosiga brevicollis (Choanoflagellate)Imported
Taxonomic identifieri81824 [NCBI]
Taxonomic lineageiEukaryotaChoanoflagellidaCodonosigidaeMonosiga
ProteomesiUP000001357 Componenti: Unassembled WGS sequence

Subcellular locationi

Nucleus UniRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi81824.JGI34214.

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.UniRule annotation
Contains 1 DOT1 domain.UniRule annotation

Phylogenomic databases

eggNOGiNOG294902.
InParanoidiA9VA99.
KOiK11427.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR025789. DOT1_dom.
IPR013110. DOT1_dom_Pfam.
IPR030445. H3-K79_meTrfase.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR21451. PTHR21451. 1 hit.
PfamiPF08123. DOT1. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51569. DOT1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9VA99-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASAEAEVS QSKPSPLKDQ AGPVQPRPAG LTPGNPVQAV VEEAASPCAS
60 70 80 90 100
SPQAPSSAPN SHRRPVGGRI GRVHLGQPGR RVPDEEDVEA IPGGSRELGI
110 120 130 140 150
TEDWFDVPPL FPPVDTTQTH LAILSPNPKG PPMLYQWPFT HMTDSSYDAG
160 170 180 190 200
FELLNSMNHI VKLCALPVPD TWADDIVACA KPGTEFASLS KVVEAFNAAM
210 220 230 240 250
RVYHKSVGEQ AERLICPTDL CEHIMNMTYS RAVTDPALLN RYKGWTAEVY
260 270 280 290 300
GEFTSKMISD VIANSNVQPD DTFVDLGSGV GQVVLQVALE GRARTSFGIE
310 320 330 340 350
KQDIPAEYAK CGAYELVKDN FLQPQYAERI TNTSVVFLNN FAFGTKVNQQ
360 370 380 390 400
LCRMFENCQA GTRLISSISL RKSDFTITAR TLNDLGCILT MRKLCYRGQG
410 420 430 440 450
VSWTARPFSY YVQTVNHQYL DQFFSKGEPV QVPFENEVGD DDDDANPDRT
460 470 480 490 500
GTSHSGAPVR DNSDDEEDND EEAEDQSAGA AGHHKTDAVG KGHSGAERDG
510 520 530 540 550
KAAAGTRPGS TKRSKGASRR RDRQSSQQSS APPSSSSGKV AAGDDSASQR
560 570 580 590 600
LVRTLTRAVA GLERRYPSGR TLRAARHQLR ALHQERSVLR QHRREYEQQL
610 620 630 640 650
QQHNQTVAAA LTQRRQQLNE SLGLDSKTDT RLTAAAAGLL HTFVCRGGQS
660 670 680 690 700
ATSSAANAQQ SVEHIRLWTK PLQQAQAVHE RLIAALRMHG QAPVADALQR
710 720 730 740 750
TPWALPRDLC ASNEHSPTRA TNGHVPVQEA SAGKAGPTGP HQSARRSSDQ
760 770 780 790 800
NGSASSQVQS AQTRGLEATP DRYAGPLSSA ETSPASTSSH SAGKRDLSGQ
810 820 830 840 850
REATNGTEHT SQAQIAGRRE SSSTGTSPTS SLAKLLGAEP SHRSGHRQGQ
860 870 880 890 900
QRPIARAREM RPPGGARPGL SSSSKRPLSS NGEPAPQVPD PKRTKDLENA
910
SSDNALERKQ KCHGPETSN
Length:919
Mass (Da):99,082
Last modified:February 5, 2008 - v1
Checksum:i529CA3D95C972687
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH991573 Genomic DNA. Translation: EDQ85503.1.
RefSeqiXP_001749694.1. XM_001749642.1.

Genome annotation databases

GeneIDi5894943.
KEGGimbr:MONBRDRAFT_34214.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH991573 Genomic DNA. Translation: EDQ85503.1.
RefSeqiXP_001749694.1. XM_001749642.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi81824.JGI34214.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5894943.
KEGGimbr:MONBRDRAFT_34214.

Phylogenomic databases

eggNOGiNOG294902.
InParanoidiA9VA99.
KOiK11427.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR025789. DOT1_dom.
IPR013110. DOT1_dom_Pfam.
IPR030445. H3-K79_meTrfase.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR21451. PTHR21451. 1 hit.
PfamiPF08123. DOT1. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51569. DOT1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MX1 / ATCC 50154Imported.

Entry informationi

Entry nameiA9VA99_MONBE
AccessioniPrimary (citable) accession number: A9VA99
Entry historyi
Integrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: April 1, 2015
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.