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Protein

Kynureninase

Gene

kynu

Organism
Monosiga brevicollis (Choanoflagellate)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.UniRule annotation

Catalytic activityi

L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation
L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: L-kynurenine degradation

This protein is involved in step 1 of the subpathway that synthesizes L-alanine and anthranilate from L-kynurenine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Kynureninase (kynu)
This subpathway is part of the pathway L-kynurenine degradation, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-alanine and anthranilate from L-kynurenine, the pathway L-kynurenine degradation and in Amino-acid degradation.

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes quinolinate from L-kynurenine.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Kynurenine 3-monooxygenase (KMO)
  2. Kynureninase (kynu)
  3. no protein annotated in this organism
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes quinolinate from L-kynurenine, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei127Pyridoxal phosphate; via amide nitrogenUniRule annotation1
Binding sitei128Pyridoxal phosphateUniRule annotation1
Binding sitei249Pyridoxal phosphateUniRule annotation1
Binding sitei252Pyridoxal phosphateUniRule annotation1
Binding sitei274Pyridoxal phosphateUniRule annotation1
Binding sitei304Pyridoxal phosphateUniRule annotation1
Binding sitei332Pyridoxal phosphateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processPyridine nucleotide biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00253; UER00329
UPA00334; UER00455

Names & Taxonomyi

Protein namesi
Recommended name:
KynureninaseUniRule annotation (EC:3.7.1.3UniRule annotation)
Alternative name(s):
L-kynurenine hydrolaseUniRule annotation
Gene namesi
Name:kynuUniRule annotation
ORF Names:26773
OrganismiMonosiga brevicollis (Choanoflagellate)
Taxonomic identifieri81824 [NCBI]
Taxonomic lineageiEukaryotaChoanoflagellidaCraspedidaSalpingoecidaeMonosiga
Proteomesi
  • UP000001357 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003610871 – 460KynureninaseAdd BLAST460

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei275N6-(pyridoxal phosphate)lysineUniRule annotation1

Proteomic databases

PRIDEiA9V3C0

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi431895.XP_001747110.1

Structurei

3D structure databases

ProteinModelPortaliA9V3C0
SMRiA9V3C0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni165 – 168Pyridoxal phosphate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the kynureninase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3846 Eukaryota
COG3844 LUCA
InParanoidiA9V3C0
KOiK01556
OMAiVCSLHAS

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_01970 Kynureninase, 1 hit
InterProiView protein in InterPro
IPR000192 Aminotrans_V_dom
IPR010111 Kynureninase
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR14084 PTHR14084, 1 hit
PfamiView protein in Pfam
PF00266 Aminotran_5, 1 hit
PIRSFiPIRSF038800 KYNU, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR01814 kynureninase, 1 hit

Sequencei

Sequence statusi: Complete.

A9V3C0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHLARELGVN LADQRLAQAL DEADPLAHLR QEFSIPQMKD IKQADLKLVE
60 70 80 90 100
AESDCIYLCG NSLGLMPKRT RTIVNEELDT WATGGVTGHF PDGPGKRPWV
110 120 130 140 150
SIDETVTDKC ARVVGALPEE VAIMNTLTVN LHLLMVSLAH TMARQVPFYR
160 170 180 190 200
PTSDRFKILV EAKAFPSDHF AVLSQLRMHG HDESALIEVK PREGEHNIRE
210 220 230 240 250
EDLLAILEEQ GDSIATVLVG GVHYYTGQFF DLQRLCAAAH NKGCTFGVDL
260 270 280 290 300
AHAVGNVPLQ LHDWDIDFAC WCTYKYLNSG PGGIAGAFIH KKHEGTSRPY
310 320 330 340 350
LQGWWGVQLN ERFRMDHDAS FMPGVRGLQL SNPGVLQTVA LLGSLEIYEQ
360 370 380 390 400
TDMASLRAKS LKLTAYLEQL MQALVNEEGH APRFEIITPT DPERRGCQLS
410 420 430 440 450
ILFKVDIDAA FEALEKRGVV CDVRRPDVMR IAPVPLYNTF TDVYRFVTTL
460
RDALNASASS
Length:460
Mass (Da):51,259
Last modified:February 5, 2008 - v1
Checksum:i8ED7320A036A9BDE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH991556 Genomic DNA Translation: EDQ88034.1
RefSeqiXP_001747110.1, XM_001747058.1

Genome annotation databases

EnsemblProtistsiEDQ88034; EDQ88034; MONBRDRAFT_26773
GeneIDi5892477
KEGGimbr:MONBRDRAFT_26773

Similar proteinsi

Entry informationi

Entry nameiKYNU_MONBE
AccessioniPrimary (citable) accession number: A9V3C0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: February 5, 2008
Last modified: May 23, 2018
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health