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A9V3C0

- KYNU_MONBE

UniProt

A9V3C0 - KYNU_MONBE

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Protein
Kynureninase
Gene
kynu, 26773
Organism
Monosiga brevicollis (Choanoflagellate)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively By similarity.UniRule annotation

Catalytic activityi

L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation
L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei127 – 1271Pyridoxal phosphate; via amide nitrogen By similarity
Binding sitei128 – 1281Pyridoxal phosphate By similarity
Binding sitei249 – 2491Pyridoxal phosphate By similarity
Binding sitei252 – 2521Pyridoxal phosphate By similarity
Binding sitei274 – 2741Pyridoxal phosphate By similarity
Binding sitei304 – 3041Pyridoxal phosphate By similarity
Binding sitei332 – 3321Pyridoxal phosphate By similarity

GO - Molecular functioni

  1. kynureninase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
  2. L-kynurenine catabolic process Source: UniProtKB-UniPathway
  3. anthranilate metabolic process Source: UniProtKB-HAMAP
  4. quinolinate biosynthetic process Source: UniProtKB-HAMAP
  5. tryptophan catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00253; UER00329.
UPA00334; UER00455.

Names & Taxonomyi

Protein namesi
Recommended name:
Kynureninase (EC:3.7.1.3)
Alternative name(s):
L-kynurenine hydrolase
Gene namesi
Name:kynu
ORF Names:26773
OrganismiMonosiga brevicollis (Choanoflagellate)
Taxonomic identifieri81824 [NCBI]
Taxonomic lineageiEukaryotaChoanoflagellidaCodonosigidaeMonosiga
ProteomesiUP000001357: Unassembled WGS sequence

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 460460KynureninaseUniRule annotation
PRO_0000361087Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei275 – 2751N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi81824.JGI26773.

Structurei

3D structure databases

ProteinModelPortaliA9V3C0.
SMRiA9V3C0. Positions 3-456.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni165 – 1684Pyridoxal phosphate binding By similarity

Sequence similaritiesi

Belongs to the kynureninase family.

Phylogenomic databases

eggNOGiCOG3844.
KOiK01556.
OMAiVWDLAHS.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01970. Kynureninase.
InterProiIPR000192. Aminotrans_V/Cys_dSase.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR14084. PTHR14084. 1 hit.
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFiPIRSF038800. KYNU. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01814. kynureninase. 1 hit.

Sequencei

Sequence statusi: Complete.

A9V3C0-1 [UniParc]FASTAAdd to Basket

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MHLARELGVN LADQRLAQAL DEADPLAHLR QEFSIPQMKD IKQADLKLVE    50
AESDCIYLCG NSLGLMPKRT RTIVNEELDT WATGGVTGHF PDGPGKRPWV 100
SIDETVTDKC ARVVGALPEE VAIMNTLTVN LHLLMVSLAH TMARQVPFYR 150
PTSDRFKILV EAKAFPSDHF AVLSQLRMHG HDESALIEVK PREGEHNIRE 200
EDLLAILEEQ GDSIATVLVG GVHYYTGQFF DLQRLCAAAH NKGCTFGVDL 250
AHAVGNVPLQ LHDWDIDFAC WCTYKYLNSG PGGIAGAFIH KKHEGTSRPY 300
LQGWWGVQLN ERFRMDHDAS FMPGVRGLQL SNPGVLQTVA LLGSLEIYEQ 350
TDMASLRAKS LKLTAYLEQL MQALVNEEGH APRFEIITPT DPERRGCQLS 400
ILFKVDIDAA FEALEKRGVV CDVRRPDVMR IAPVPLYNTF TDVYRFVTTL 450
RDALNASASS 460
Length:460
Mass (Da):51,259
Last modified:February 5, 2008 - v1
Checksum:i8ED7320A036A9BDE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH991556 Genomic DNA. Translation: EDQ88034.1.
RefSeqiXP_001747110.1. XM_001747058.1.

Genome annotation databases

GeneIDi5892477.
KEGGimbr:MONBRDRAFT_26773.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH991556 Genomic DNA. Translation: EDQ88034.1 .
RefSeqi XP_001747110.1. XM_001747058.1.

3D structure databases

ProteinModelPortali A9V3C0.
SMRi A9V3C0. Positions 3-456.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 81824.JGI26773.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 5892477.
KEGGi mbr:MONBRDRAFT_26773.

Phylogenomic databases

eggNOGi COG3844.
KOi K01556.
OMAi VWDLAHS.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00329 .
UPA00334 ; UER00455 .

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPi MF_01970. Kynureninase.
InterProi IPR000192. Aminotrans_V/Cys_dSase.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR14084. PTHR14084. 1 hit.
Pfami PF00266. Aminotran_5. 1 hit.
[Graphical view ]
PIRSFi PIRSF038800. KYNU. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR01814. kynureninase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MX1 / ATCC 50154.

Entry informationi

Entry nameiKYNU_MONBE
AccessioniPrimary (citable) accession number: A9V3C0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: February 5, 2008
Last modified: June 11, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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