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A9V3C0

- KYNU_MONBE

UniProt

A9V3C0 - KYNU_MONBE

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Protein

Kynureninase

Gene

kynu

Organism
Monosiga brevicollis (Choanoflagellate)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.UniRule annotation

Catalytic activityi

L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation
L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation

Cofactori

Pyridoxal phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei127 – 1271Pyridoxal phosphate; via amide nitrogenUniRule annotation
Binding sitei128 – 1281Pyridoxal phosphateUniRule annotation
Binding sitei249 – 2491Pyridoxal phosphateUniRule annotation
Binding sitei252 – 2521Pyridoxal phosphateUniRule annotation
Binding sitei274 – 2741Pyridoxal phosphateUniRule annotation
Binding sitei304 – 3041Pyridoxal phosphateUniRule annotation
Binding sitei332 – 3321Pyridoxal phosphateUniRule annotation

GO - Molecular functioni

  1. kynureninase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
  2. anthranilate metabolic process Source: UniProtKB-HAMAP
  3. L-kynurenine catabolic process Source: UniProtKB-UniPathway
  4. quinolinate biosynthetic process Source: UniProtKB-HAMAP
  5. tryptophan catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00253; UER00329.
UPA00334; UER00455.

Names & Taxonomyi

Protein namesi
Recommended name:
KynureninaseUniRule annotation (EC:3.7.1.3UniRule annotation)
Alternative name(s):
L-kynurenine hydrolaseUniRule annotation
Gene namesi
Name:kynuUniRule annotation
ORF Names:26773
OrganismiMonosiga brevicollis (Choanoflagellate)
Taxonomic identifieri81824 [NCBI]
Taxonomic lineageiEukaryotaChoanoflagellidaCodonosigidaeMonosiga
ProteomesiUP000001357: Unassembled WGS sequence

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 460460KynureninasePRO_0000361087Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei275 – 2751N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi81824.JGI26773.

Structurei

3D structure databases

ProteinModelPortaliA9V3C0.
SMRiA9V3C0. Positions 3-456.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni165 – 1684Pyridoxal phosphate bindingUniRule annotation

Sequence similaritiesi

Belongs to the kynureninase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG3844.
InParanoidiA9V3C0.
KOiK01556.
OMAiVWDLAHS.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01970. Kynureninase.
InterProiIPR000192. Aminotrans_V_dom.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR14084. PTHR14084. 1 hit.
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFiPIRSF038800. KYNU. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01814. kynureninase. 1 hit.

Sequencei

Sequence statusi: Complete.

A9V3C0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHLARELGVN LADQRLAQAL DEADPLAHLR QEFSIPQMKD IKQADLKLVE
60 70 80 90 100
AESDCIYLCG NSLGLMPKRT RTIVNEELDT WATGGVTGHF PDGPGKRPWV
110 120 130 140 150
SIDETVTDKC ARVVGALPEE VAIMNTLTVN LHLLMVSLAH TMARQVPFYR
160 170 180 190 200
PTSDRFKILV EAKAFPSDHF AVLSQLRMHG HDESALIEVK PREGEHNIRE
210 220 230 240 250
EDLLAILEEQ GDSIATVLVG GVHYYTGQFF DLQRLCAAAH NKGCTFGVDL
260 270 280 290 300
AHAVGNVPLQ LHDWDIDFAC WCTYKYLNSG PGGIAGAFIH KKHEGTSRPY
310 320 330 340 350
LQGWWGVQLN ERFRMDHDAS FMPGVRGLQL SNPGVLQTVA LLGSLEIYEQ
360 370 380 390 400
TDMASLRAKS LKLTAYLEQL MQALVNEEGH APRFEIITPT DPERRGCQLS
410 420 430 440 450
ILFKVDIDAA FEALEKRGVV CDVRRPDVMR IAPVPLYNTF TDVYRFVTTL
460
RDALNASASS
Length:460
Mass (Da):51,259
Last modified:February 5, 2008 - v1
Checksum:i8ED7320A036A9BDE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH991556 Genomic DNA. Translation: EDQ88034.1.
RefSeqiXP_001747110.1. XM_001747058.1.

Genome annotation databases

GeneIDi5892477.
KEGGimbr:MONBRDRAFT_26773.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH991556 Genomic DNA. Translation: EDQ88034.1 .
RefSeqi XP_001747110.1. XM_001747058.1.

3D structure databases

ProteinModelPortali A9V3C0.
SMRi A9V3C0. Positions 3-456.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 81824.JGI26773.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 5892477.
KEGGi mbr:MONBRDRAFT_26773.

Phylogenomic databases

eggNOGi COG3844.
InParanoidi A9V3C0.
KOi K01556.
OMAi VWDLAHS.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00329 .
UPA00334 ; UER00455 .

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPi MF_01970. Kynureninase.
InterProi IPR000192. Aminotrans_V_dom.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR14084. PTHR14084. 1 hit.
Pfami PF00266. Aminotran_5. 1 hit.
[Graphical view ]
PIRSFi PIRSF038800. KYNU. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR01814. kynureninase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MX1 / ATCC 50154.

Entry informationi

Entry nameiKYNU_MONBE
AccessioniPrimary (citable) accession number: A9V3C0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: February 5, 2008
Last modified: October 29, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3