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Protein

L-lactate dehydrogenase

Gene

32392

Organism
Monosiga brevicollis (Choanoflagellate)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-lactate + NAD+ = pyruvate + NADH.UniRule annotation

Pathwayi: pyruvate fermentation to lactate

This protein is involved in step 1 of the subpathway that synthesizes (S)-lactate from pyruvate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. L-lactate dehydrogenase (32392)
This subpathway is part of the pathway pyruvate fermentation to lactate, which is itself part of Fermentation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-lactate from pyruvate, the pathway pyruvate fermentation to lactate and in Fermentation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei74SubstrateUniRule annotation1
Binding sitei106SubstrateUniRule annotation1
Binding sitei137SubstrateUniRule annotation1
Active sitei161Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
LigandNADUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00554; UER00611.

Names & Taxonomyi

Protein namesi
Recommended name:
L-lactate dehydrogenaseUniRule annotation (EC:1.1.1.27UniRule annotation)
Gene namesi
ORF Names:32392Imported
OrganismiMonosiga brevicollis (Choanoflagellate)Imported
Taxonomic identifieri81824 [NCBI]
Taxonomic lineageiEukaryotaChoanoflagellidaCraspedidaSalpingoecidaeMonosiga
Proteomesi
  • UP000001357 Componenti: Unassembled WGS sequence

Interactioni

Protein-protein interaction databases

STRINGi431895.XP_001745899.1.

Structurei

3D structure databases

ProteinModelPortaliA9UZ89.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 128Ldh_1_NInterPro annotationAdd BLAST127
Domaini131 – 206Ldh_1_CInterPro annotationAdd BLAST76
Domaini224 – 303Ldh_1_CInterPro annotationAdd BLAST80

Sequence similaritiesi

Belongs to the LDH/MDH superfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG1495. Eukaryota.
COG0039. LUCA.
InParanoidiA9UZ89.
KOiK00016.
OMAiMDLMQTA.

Family and domain databases

Gene3Di3.90.110.10. 1 hit.
InterProiView protein in InterPro
IPR001557. L-lactate/malate_DH.
IPR018177. L-lactate_DH_AS.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR036291. NAD(P)-bd_dom_sf.
PfamiView protein in Pfam
PF02866. Ldh_1_C. 2 hits.
PF00056. Ldh_1_N. 1 hit.
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
PROSITEiView protein in PROSITE
PS00064. L_LDH. 1 hit.

Sequencei

Sequence statusi: Complete.

A9UZ89-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MACAYSLLQK GLVGELVLAD VMKDKLKGEV MDLQHGGAYQ HGRIVECDDD
60 70 80 90 100
YEASRNSDIC IIAAGVRQQD GETRLQLADR NRDVLKHIIP PLVAKSPNTV
110 120 130 140 150
ILMVSNPVDI MTYIAWQLSG LPANRVLGSG TFLDSSRFRT LIGQELDVNA
160 170 180 190 200
SSVHAWIVGE HGDSSVPVWS SVNIAGVHLD TSHSANFDKI HERVVSAAYD
210 220 230 240 250
VIKLKQKGYL CPYQSRFLPH RQGYTNWAIG SAVSTLCGII LQNQQRVVPV
260 270 280 290 300
STYVKGVHGI DESVFLSLPC VLGSRGVERI LHQPLDDKEL QSLQSSAKNL

WAVQKDIKF
Length:309
Mass (Da):34,026
Last modified:February 5, 2008 - v1
Checksum:i51B599B3C100DEDB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH991551 Genomic DNA. Translation: EDQ89323.1.
RefSeqiXP_001745899.1. XM_001745847.1.

Genome annotation databases

EnsemblProtistsiEDQ89323; EDQ89323; MONBRDRAFT_32392.
GeneIDi5891079.
KEGGimbr:MONBRDRAFT_32392.

Entry informationi

Entry nameiA9UZ89_MONBE
AccessioniPrimary (citable) accession number: A9UZ89
Entry historyiIntegrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: November 22, 2017
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported