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Protein

Histone deacetylase

Gene

15424

Organism
Monosiga brevicollis (Choanoflagellate)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of an N6-acetyl-lysine residue of a histone to yield a deacetylated histone.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei94SubstrateUniRule annotation1
Active sitei136Proton acceptorUniRule annotation1
Binding sitei144Substrate; via carbonyl oxygenUniRule annotation1
Metal bindingi171Divalent metal cationUniRule annotation1
Metal bindingi173Divalent metal cationUniRule annotation1
Metal bindingi260Divalent metal cationUniRule annotation1
Binding sitei299SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulatorUniRule annotationSAAS annotation, HydrolaseUniRule annotationSAAS annotation
Biological processTranscription, Transcription regulationUniRule annotationSAAS annotation
LigandMetal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylaseUniRule annotationSAAS annotation (EC:3.5.1.98UniRule annotationSAAS annotation)
Gene namesi
ORF Names:15424Imported
OrganismiMonosiga brevicollis (Choanoflagellate)Imported
Taxonomic identifieri81824 [NCBI]
Taxonomic lineageiEukaryotaChoanoflagellidaCraspedidaSalpingoecidaeMonosiga
Proteomesi
  • UP000001357 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Nucleus UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi431895.XP_001744309.1.

Structurei

3D structure databases

ProteinModelPortaliA9UV35.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 314Hist_deacetylInterPro annotationAdd BLAST292

Sequence similaritiesi

Belongs to the histone deacetylase family. HD Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG1342. Eukaryota.
COG0123. LUCA.
InParanoidiA9UV35.
KOiK11404.
OMAiPRAWTHL.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiView protein in InterPro
IPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiView protein in Pfam
PF00850. Hist_deacetyl. 1 hit.
PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSiPR01270. HDASUPER.
PR01271. HISDACETLASE.

Sequencei

Sequence statusi: Complete.

A9UV35-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRPRVAYFF DADVGNFHYG PGHPMKPHRL ALTHSLVLEY GLWSKMEIFR
60 70 80 90 100
PYRASPEDMG RFHATDYINF LQRVTPDNYR TFGSYLQRFN VGDDCPVFDG
110 120 130 140 150
IFDFCSIYAG ASIEGAVKLN NKQCDVAINW SGGLHHAKKF EASGFCYVND
160 170 180 190 200
IVLAILELLK QHPRVLYIDI DIHHGDGVEE AFYTTDRVMT VSFHKYGGHF
210 220 230 240 250
FPGTGVMYEL GAGRGRYYAL NVPLKDGIDD MGYNELFKPV MREVISKFQP
260 270 280 290 300
SAIVLQCGAD SLGCDRLGCF NLSIAGHGNC VEFIKSFNLP LLVLGGGGYT
310 320 330 340 350
IRNVARCWTH ETGILLDEHL SEDLPYNDYF QYFGPDFKLH PNVATSVENQ
360 370 380 390
NSKEYLDKLR EHVFEQLGQL DGAPSVMMQE VCALDECLGR RMSRKLGSS
Length:399
Mass (Da):45,031
Last modified:February 5, 2008 - v1
Checksum:i1CBDBF5B27E39B66
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH991546 Genomic DNA. Translation: EDQ91012.1.
RefSeqiXP_001744309.1. XM_001744257.1.

Genome annotation databases

EnsemblProtistsiEDQ91012; EDQ91012; MONBRDRAFT_15424.
GeneIDi5889522.
KEGGimbr:MONBRDRAFT_15424.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiA9UV35_MONBE
AccessioniPrimary (citable) accession number: A9UV35
Entry historyiIntegrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: July 5, 2017
This is version 47 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported