Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Histone deacetylase

Gene

15424

Organism
Monosiga brevicollis (Choanoflagellate)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.UniRule annotation

GO - Molecular functioni

  1. NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
  2. NAD-dependent histone deacetylase activity (H3-K18 specific) Source: UniProtKB-EC
  3. NAD-dependent histone deacetylase activity (H3-K9 specific) Source: UniProtKB-EC
  4. NAD-dependent histone deacetylase activity (H4-K16 specific) Source: UniProtKB-EC

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulatorUniRule annotation, HydrolaseUniRule annotationSAAS annotation

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylaseUniRule annotation (EC:3.5.1.98UniRule annotation)
Gene namesi
ORF Names:15424Imported
OrganismiMonosiga brevicollis (Choanoflagellate)Imported
Taxonomic identifieri81824 [NCBI]
Taxonomic lineageiEukaryotaChoanoflagellidaCodonosigidaeMonosiga
ProteomesiUP000001357 Componenti: Unassembled WGS sequence

Subcellular locationi

Nucleus UniRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi81824.JGI15424.

Structurei

3D structure databases

ProteinModelPortaliA9UV35.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histone deacetylase family. HD Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiNOG296133.
InParanoidiA9UV35.
KOiK11404.
OMAiLFDFCSM.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSiPR01270. HDASUPER.
PR01271. HISDACETLASE.

Sequencei

Sequence statusi: Complete.

A9UV35-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRPRVAYFF DADVGNFHYG PGHPMKPHRL ALTHSLVLEY GLWSKMEIFR
60 70 80 90 100
PYRASPEDMG RFHATDYINF LQRVTPDNYR TFGSYLQRFN VGDDCPVFDG
110 120 130 140 150
IFDFCSIYAG ASIEGAVKLN NKQCDVAINW SGGLHHAKKF EASGFCYVND
160 170 180 190 200
IVLAILELLK QHPRVLYIDI DIHHGDGVEE AFYTTDRVMT VSFHKYGGHF
210 220 230 240 250
FPGTGVMYEL GAGRGRYYAL NVPLKDGIDD MGYNELFKPV MREVISKFQP
260 270 280 290 300
SAIVLQCGAD SLGCDRLGCF NLSIAGHGNC VEFIKSFNLP LLVLGGGGYT
310 320 330 340 350
IRNVARCWTH ETGILLDEHL SEDLPYNDYF QYFGPDFKLH PNVATSVENQ
360 370 380 390
NSKEYLDKLR EHVFEQLGQL DGAPSVMMQE VCALDECLGR RMSRKLGSS
Length:399
Mass (Da):45,031
Last modified:February 4, 2008 - v1
Checksum:i1CBDBF5B27E39B66
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH991546 Genomic DNA. Translation: EDQ91012.1.
RefSeqiXP_001744309.1. XM_001744257.1.

Genome annotation databases

GeneIDi5889522.
KEGGimbr:MONBRDRAFT_15424.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH991546 Genomic DNA. Translation: EDQ91012.1.
RefSeqiXP_001744309.1. XM_001744257.1.

3D structure databases

ProteinModelPortaliA9UV35.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi81824.JGI15424.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5889522.
KEGGimbr:MONBRDRAFT_15424.

Phylogenomic databases

eggNOGiNOG296133.
InParanoidiA9UV35.
KOiK11404.
OMAiLFDFCSM.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSiPR01270. HDASUPER.
PR01271. HISDACETLASE.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MX1 / ATCC 50154Imported.

Entry informationi

Entry nameiA9UV35_MONBE
AccessioniPrimary (citable) accession number: A9UV35
Entry historyi
Integrated into UniProtKB/TrEMBL: February 4, 2008
Last sequence update: February 4, 2008
Last modified: March 3, 2015
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.