ID A9UUQ0_MONBE Unreviewed; 1182 AA. AC A9UUQ0; DT 05-FEB-2008, integrated into UniProtKB/TrEMBL. DT 05-FEB-2008, sequence version 1. DT 24-JAN-2024, entry version 68. DE RecName: Full=Protein kinase domain-containing protein {ECO:0000259|PROSITE:PS50011}; GN ORFNames=MONBRDRAFT_23745 {ECO:0000313|EMBL:EDQ90942.1}; OS Monosiga brevicollis (Choanoflagellate). OC Eukaryota; Choanoflagellata; Craspedida; Salpingoecidae; Monosiga. OX NCBI_TaxID=81824 {ECO:0000313|EMBL:EDQ90942.1, ECO:0000313|Proteomes:UP000001357}; RN [1] {ECO:0000313|EMBL:EDQ90942.1, ECO:0000313|Proteomes:UP000001357} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=MX1 / ATCC 50154 {ECO:0000313|Proteomes:UP000001357}; RX PubMed=18273011; DOI=10.1038/nature06617; RG JGI Sequencing; RA King N., Westbrook M.J., Young S.L., Kuo A., Abedin M., Chapman J., RA Fairclough S., Hellsten U., Isogai Y., Letunic I., Marr M., Pincus D., RA Putnam N., Rokas A., Wright K.J., Zuzow R., Dirks W., Good M., RA Goodstein D., Lemons D., Li W., Lyons J.B., Morris A., Nichols S., RA Richter D.J., Salamov A., Bork P., Lim W.A., Manning G., Miller W.T., RA McGinnis W., Shapiro H., Tjian R., Grigoriev I.V., Rokhsar D.; RT "The genome of the choanoflagellate Monosiga brevicollis and the origin of RT metazoans."; RL Nature 451:783-788(2008). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CH991546; EDQ90942.1; -; Genomic_DNA. DR RefSeq; XP_001744239.1; XM_001744187.1. DR AlphaFoldDB; A9UUQ0; -. DR STRING; 81824.A9UUQ0; -. DR EnsemblProtists; EDQ90942; EDQ90942; MONBRDRAFT_23745. DR GeneID; 5889643; -. DR KEGG; mbr:MONBRDRAFT_23745; -. DR eggNOG; KOG0660; Eukaryota. DR eggNOG; KOG4177; Eukaryota. DR InParanoid; A9UUQ0; -. DR Proteomes; UP000001357; Unassembled WGS sequence. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW. DR GO; GO:0005524; F:ATP binding; IEA:InterPro. DR GO; GO:0003950; F:NAD+ ADP-ribosyltransferase activity; IEA:InterPro. DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro. DR Gene3D; 3.90.228.10; -; 1. DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1. DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1. DR InterPro; IPR002110; Ankyrin_rpt. DR InterPro; IPR036770; Ankyrin_rpt-contain_sf. DR InterPro; IPR011009; Kinase-like_dom_sf. DR InterPro; IPR012317; Poly(ADP-ribose)pol_cat_dom. DR InterPro; IPR000719; Prot_kinase_dom. DR InterPro; IPR008271; Ser/Thr_kinase_AS. DR PANTHER; PTHR24144; ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 49; 1. DR PANTHER; PTHR24144:SF5; MYND-TYPE DOMAIN-CONTAINING PROTEIN; 1. DR Pfam; PF00644; PARP; 1. DR Pfam; PF00069; Pkinase; 1. DR SMART; SM00220; S_TKc; 1. DR SUPFAM; SSF56399; ADP-ribosylation; 1. DR SUPFAM; SSF48403; Ankyrin repeat; 1. DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1. DR PROSITE; PS50088; ANK_REPEAT; 1. DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1. DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1. PE 4: Predicted; KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001357}; KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1..22 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 23..1182 FT /note="Protein kinase domain-containing protein" FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5002744443" FT TRANSMEM 45..69 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 99..118 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 130..152 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 164..189 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 1123..1150 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 1156..1181 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT REPEAT 239..271 FT /note="ANK" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023" FT DOMAIN 633..929 FT /note="Protein kinase" FT /evidence="ECO:0000259|PROSITE:PS50011" FT REGION 271..381 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 271..297 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 337..368 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 1182 AA; 130128 MW; 01A08FC2A6763C5D CRC64; MCWMRWMCWM CGMCVLCTST QSLLTVCVCL SLCLSLSVSL FALSLLSLCL SLSLCLSLSL CLSLTLCLFV SLSLSLPPYL SLLSLSLSLS VSLSLSLPIS LSLLFFCLSV SLSVCLSLSR SLSLCLSVSL SVSLSLCLSV SLSVSLCLSL SLSLSLSLSL SLSLSLSVSL SLCLCLSVCL SLSLSLSVFR LPYFGQCNRY RVAHHLLTVL PLQQLSPLTC LLSLAIGYTR SSPLPGALND WRPLHKAYSN GRTDVARILI KCGVPRNVKT KGKRTPLDLA KQRGHYAKMK QMEKDISESD SATPVAPLSE KITPLTLGTP DTESSPDIEA LPDTEASPDT EASTDTEALP DTEASPETEA SPDTEASPDT EASPDAKAST HEWERLFDIV SKACDNEDVK EEIQNISKWK DWSIGLPVIQ DMKTAVNQIA GNARILHDKM KKASADQSRT LHDVLTEYKT LTTETNLKTL RNELSTAMPS APDDVLLFGS MILFIIEDLD DTARAQHSHP CSATDSATSS LESFCQKESD SKRKMYADLW QSRRAGLQFK QQFEDLLCWQ ADTCSALDDC IELCPEVDAN FSVEHVTKLG RRLNQHFPPL LILLQPFQSL CEKQMHPSLV NGLPKSLAFE LWAEIDQTLT LSSLGPLALE YKDNHEVYQA KAALPNSDQK HLAVKKYALA RQQKEALCRT FLHELYVMRK LEHPHIIKVF GAFVDEHNGQ PGAFLVQPWC TQGDLQQWLH KVRQQATLNV IERLMNELRS ALGFMHSKGL VHRDVKLSNV MLDGEEACPK VCLGDFDISK AAAKSTLLSG TTTASMGTKG YVAPEVLFAV SSVGARPSQD AFSFGCVLYN TYMFPQTVPP AKSLSDEVVD RCQWDLQADA ASFKFAHLAA EMRNPKSEVH TEMRALLSPD SSKRPSILET ALVPRQPSAT AQIGSAIDVL REAPSELIPE VANFLKQLCT DEQGCPEIRV RWVQAVHNPV LWERYSTKRQ EMLNDKIIRL GFDNRFAGSH AGRRFGLGIY LTDDPVKSHQ YTEPRQNGER VLIIARALLG HAYVHASPLK EAHVHASPLK EALAPPLLPD APNNERYDSV IVTPPGEASE VVIFDNAQTY PELILLLWRF RKCVCVCVCV CVCVCVCVCV CVCVCVCVCV CVCVYVCVFV CMCVCVCVCV CVCVCVCVCV FV //