A9UTL4 (A9UTL4_MONBE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Adenosylhomocysteinase RuleBase RU000548
EC=3.3.1.1 RuleBase RU000548

Gene names

ORF Names:

34987

Organism

Monosiga brevicollis (Choanoflagellate)

Taxonomic identifier

81824 [NCBI]

Taxonomic lineage

Eukaryota › Choanoflagellida › Codonosigidae › Monosiga

Protein attributes

Sequence length	432 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine. RuleBase RU000548
Cofactor	NAD By similarity. RuleBase RU000548
Pathway	Amino-acid biosynthesis; homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1. RuleBase RU000548
Sequence similarities	Belongs to the adenosylhomocysteinase family. RuleBase RU004166

Ontologies

Keywords
Biological process	One-carbon metabolism RuleBase RU000548
Ligand	NAD RuleBase RU000548
Molecular function	Hydrolase RuleBase RU000548
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	one-carbon metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	adenosylhomocysteinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Binding site	56	1	Substrate By similarity PIRSR PIRSR001109-1
	Binding site	131	1	Substrate By similarity PIRSR PIRSR001109-1
	Binding site	156	1	Substrate By similarity PIRSR PIRSR001109-1
	Binding site	186	1	Substrate By similarity PIRSR PIRSR001109-1
	Binding site	190	1	Substrate By similarity PIRSR PIRSR001109-1

Sequences

	Sequence		Length	Mass (Da)
	A9UTL4 [UniParc]. Last modified February 5, 2008. Version 1. Checksum: 14CFDE940D47FC8C	FASTA	432	47,155
	10 20 30 40 50 60 MAKPAYKVAN IELAELGRKD IMLSENEMPG LMHLRAKYGP SQPLKGARIA GCLHMTTQTA 70 80 90 100 110 120 VLIETLTALG AQVQWSSCNI FSTQDEAAAA IAATGVPVYA WKGETDEEYM WCIEQTLVFA 130 140 150 160 170 180 DGQPLNMILD DGGDLTNLVH EKYPQYLENI KGVSEETTTG VHNLYKMLEK GILKVPSINV 190 200 210 220 230 240 NDSVTKSKFD NLYGCRESLL DGIKRATDVM IAGKPAVVAG YGDVGKGCAQ ALKAFGARVM 250 260 270 280 290 300 VTEIDPINAL QAAMEGYEVT TMDEACKEAM IFVTATGCKD ILTAKHFEQM KDDAIVCNIG 310 320 330 340 350 360 HFDCEINVAW LKANAKSVMN IKPQVDRYEL ASGRHIILLA EGRLVNLGCA TGHPSFVMSN 370 380 390 400 410 420 SFSNQVLAQI ELWTKAEQYP VGVHFLPKAL DEEVANAHLA KIGVKLTKLS DDQSTYLGIP 430 SAGPFKPNHY RY

References

[1]

"The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans." JGI Sequencing King N., Westbrook M.J., Young S.L., Kuo A., Abedin M., Chapman J., Fairclough S., Hellsten U., Isogai Y., Letunic I., Marr M., Pincus D., Putnam N., Rokas A., Wright K.J., Zuzow R., Dirks W., Good M. , Goodstein D., Lemons D., Li W., Lyons J.B., Morris A., Nichols S., Richter D.J., Salamov A., Bork P., Lim W.A., Manning G., Miller W.T., McGinnis W., Shapiro H., Tjian R., Grigoriev I.V., Rokhsar D. Nature 451:783-788(2008) [PubMed: 18273011] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MX1 / ATCC 50154.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CH991545 Genomic DNA. Translation: EDQ91265.1.
RefSeq	XP_001743687.1. XM_001743635.1.
3D structure databases
ProteinModelPortal	A9UTL4.
SMR	A9UTL4. Positions 6-432.
ModBase	Search...
Protein-protein interaction databases
STRING	A9UTL4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5889042.
KEGG	mbr:MONBRDRAFT_34987.
Phylogenomic databases
OMA	SAQVWVT.
ProtClustDB	PTZ00075.
Family and domain databases
HAMAP	MF_00563. AdoHcyase. [Tree]
InterPro	IPR000043. Adenosylhomocysteinase. IPR015878. Ado_hCys_hydrolase_NAD-bd. IPR020082. S-Ado-L-homoCys_hydrolase_CS. [Graphical view]
KO	K01251.
PANTHER	PTHR23420. Ad_hcy_hydrolase. 1 hit.
Pfam	PF05221. AdoHcyase. 1 hit. PF00670. AdoHcyase_NAD. 1 hit. [Graphical view]
PIRSF	PIRSF001109. Ad_hcy_hydrolase. 1 hit.
SMART	SM00996. AdoHcyase. 1 hit. SM00997. AdoHcyase_NAD. 1 hit. [Graphical view]
TIGRFAMs	TIGR00936. AhcY. 1 hit.
PROSITE	PS00738. ADOHCYASE_1. 1 hit. PS00739. ADOHCYASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A9UTL4_MONBE

Accession

Primary (citable) accession number: A9UTL4

Entry history

Integrated into UniProtKB/TrEMBL:	February 5, 2008
Last sequence update:	February 5, 2008
Last modified:	January 25, 2012
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)