ID   A9UMR6_XENTR            Unreviewed;       476 AA.
AC   A9UMR6;
DT   05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT   05-FEB-2008, sequence version 1.
DT   27-MAR-2024, entry version 66.
DE   SubName: Full=Abi2 protein {ECO:0000313|EMBL:AAI57765.1};
DE   SubName: Full=Abl interactor 2 isoform X9 {ECO:0000313|RefSeq:XP_031748517.1};
GN   Name=abi2 {ECO:0000313|EMBL:AAI57765.1,
GN   ECO:0000313|RefSeq:XP_031748517.1,
GN   ECO:0000313|Xenbase:XB-GENE-944589};
GN   Synonyms=abi-2 {ECO:0000313|RefSeq:XP_031748517.1}, abi1
GN   {ECO:0000313|RefSeq:XP_031748517.1}, abi2b
GN   {ECO:0000313|RefSeq:XP_031748517.1}, ablbp3
GN   {ECO:0000313|RefSeq:XP_031748517.1}, aip-1
GN   {ECO:0000313|RefSeq:XP_031748517.1}, argbpia
GN   {ECO:0000313|RefSeq:XP_031748517.1}, argbpib
GN   {ECO:0000313|RefSeq:XP_031748517.1}, ssh3bp2
GN   {ECO:0000313|RefSeq:XP_031748517.1}, xlan4
GN   {ECO:0000313|RefSeq:XP_031748517.1};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364 {ECO:0000313|EMBL:AAI57765.1};
RN   [1] {ECO:0000313|EMBL:AAI57765.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain {ECO:0000313|EMBL:AAI57765.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|RefSeq:XP_031748517.1}
RP   IDENTIFICATION.
RC   STRAIN=Nigerian {ECO:0000313|RefSeq:XP_031748517.1};
RC   TISSUE=Liver and blood {ECO:0000313|RefSeq:XP_031748517.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell projection, filopodium
CC       {ECO:0000256|ARBA:ARBA00004486}. Cell projection, lamellipodium
CC       {ECO:0000256|ARBA:ARBA00004510}.
CC   -!- SIMILARITY: Belongs to the ABI family. {ECO:0000256|ARBA:ARBA00010020}.
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DR   EMBL; BC157764; AAI57765.1; -; mRNA.
DR   RefSeq; XP_031748517.1; XM_031892657.1.
DR   Xenbase; XB-GENE-944589; abi2.
DR   Proteomes; UP000008143; Chromosome 9.
DR   GO; GO:0030175; C:filopodium; IEA:UniProtKB-SubCell.
DR   GO; GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.
DR   CDD; cd11972; SH3_Abi2; 1.
DR   Gene3D; 6.10.140.1620; -; 1.
DR   Gene3D; 2.30.30.40; SH3 Domains; 1.
DR   InterPro; IPR028457; ABI.
DR   InterPro; IPR035726; Abi2_SH3.
DR   InterPro; IPR012849; Abl-interactor_HHR_dom.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   InterPro; IPR000727; T_SNARE_dom.
DR   PANTHER; PTHR10460:SF26; ABL INTERACTOR 2; 1.
DR   PANTHER; PTHR10460; ABL INTERACTOR FAMILY MEMBER; 1.
DR   Pfam; PF07815; Abi_HHR; 1.
DR   Pfam; PF00018; SH3_1; 1.
DR   PRINTS; PR00452; SH3DOMAIN.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF50044; SH3-domain; 1.
DR   PROSITE; PS50002; SH3; 1.
DR   PROSITE; PS50192; T_SNARE; 1.
PE   2: Evidence at transcript level;
KW   Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW   ProRule:PRU00192}.
FT   DOMAIN          45..107
FT                   /note="T-SNARE coiled-coil homology"
FT                   /evidence="ECO:0000259|PROSITE:PS50192"
FT   DOMAIN          414..473
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   REGION          154..318
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          360..393
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        212..260
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        362..383
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   476 AA;  52625 MW;  1D38E5D08DD269FC CRC64;
     MAELQMLLEE EIPGGRRALL DSYTNLERVA DYCENNYIQS PDKQRALEET KAYTTQSLAS
     VAYLINTLAN NVLQMLDIQA SQLRRMESSI NHISQTVDIH KEKVARREIG ILTTNKNTSR
     THKIIAPANL ERPVRYIRKP IDYTILDDTG HGVKVSTQNM KMGGLPRTTP PTQKPPSPPM
     TGKGTLGRHS PYRTLEPVRP PVVPNDYVPS PTRNMAPPQQ QSPVRTASVN QRNRTYSSSG
     SSGGSHPSSR SSSRENSGSG SVGVPIAVPT PSPPSVFPGH PAQFYSMNRP VSRHNPPTIG
     GSLPYRRPPS MTTQPSLQNQ INGGPFYSQN PVSHAPPPPS ILQVTPQLPL MGFVARVQEN
     ITETPPPPPP AEEPVFDESP PPPPPPEDYE EEEAAVVEYS DPYAEEDPPW APRTYLEKVV
     AIYDYSKDKE DELSFQEGAI IYVIKKNDDG WYEGVMNGVT GLFPGNYVES IMHYSE
//