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A9UMM1

- TRMBB_XENTR

UniProt

A9UMM1 - TRMBB_XENTR

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Protein

tRNA (guanine-N(7)-)-methyltransferase B

Gene

mettl1-B

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei61 – 611S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation
Binding sitei137 – 1371S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation
Active sitei140 – 1401UniRule annotation

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB
  2. tRNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. RNA (guanine-N7)-methylation Source: GOC
  2. tRNA modification Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

RNA-binding, S-adenosyl-L-methionine, tRNA-binding

Enzyme and pathway databases

UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferase BUniRule annotation (EC:2.1.1.33UniRule annotation)
Alternative name(s):
Methyltransferase-like protein 1-BUniRule annotation
tRNA (guanine(46)-N(7))-methyltransferase BUniRule annotation
tRNA(m7G46)-methyltransferase BUniRule annotation
Gene namesi
Name:mettl1-B
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143: Unplaced

Subcellular locationi

Nucleus UniRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 241241tRNA (guanine-N(7)-)-methyltransferase BPRO_0000370561Add
BLAST

Interactioni

Subunit structurei

Forms a complex with wdr4.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA9UMM1.
SMRiA9UMM1. Positions 27-239.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni84 – 852S-adenosyl-L-methionine bindingUniRule annotation
Regioni117 – 1182S-adenosyl-L-methionine bindingUniRule annotation
Regioni215 – 2173S-adenosyl-L-methionine bindingUniRule annotation

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

Phylogenomic databases

InParanoidiA9UMM1.
KOiK03439.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_03055. tRNA_methyltr_TrmB_euk.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR025763. Trm8_euk.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9UMM1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSVCMPQKRY YRQRAHSNPM ADHTFQYPVC PEQMDWSPLY PQYFPQQEEA
60 70 80 90 100
GGAQVEFADI GCGYGGLLVQ LSLLFPQQLI LGLEIRVKVS DYVQDRIRSL
110 120 130 140 150
RVAEPGRYQN IACLRSNAMK YLPNFFRKGQ LSKMFFLFPD PHFKKTKHKW
160 170 180 190 200
RIISPTLLAE YAYTLRIGGL VYTNTDVEEV HEWIVQHFSD HPLFSRVTEE
210 220 230 240
QLADDIIVGH LGTCTEEGKK VQRNGGKNFL AVFRRVEDPQ T
Length:241
Mass (Da):27,951
Last modified:February 5, 2008 - v1
Checksum:i5DC526C10E4F5500
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC157713 mRNA. Translation: AAI57714.1.
RefSeqiNP_001107533.1. NM_001114061.1.
UniGeneiStr.77345.

Genome annotation databases

GeneIDi100135397.
KEGGixtr:100135397.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC157713 mRNA. Translation: AAI57714.1 .
RefSeqi NP_001107533.1. NM_001114061.1.
UniGenei Str.77345.

3D structure databases

ProteinModelPortali A9UMM1.
SMRi A9UMM1. Positions 27-239.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100135397.
KEGGi xtr:100135397.

Organism-specific databases

CTDi 100135397.

Phylogenomic databases

InParanoidi A9UMM1.
KOi K03439.

Enzyme and pathway databases

UniPathwayi UPA00989 .

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_03055. tRNA_methyltr_TrmB_euk.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR025763. Trm8_euk.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: TGA IC.
    Tissue: Testis.

Entry informationi

Entry nameiTRMBB_XENTR
AccessioniPrimary (citable) accession number: A9UMM1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: February 5, 2008
Last modified: October 29, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3