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A9UMM1

- TRMBB_XENTR

UniProt

A9UMM1 - TRMBB_XENTR

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Protein

tRNA (guanine-N(7)-)-methyltransferase B

Gene
mettl1-B
Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei61 – 611S-adenosyl-L-methionine; via carbonyl oxygen By similarity
Binding sitei137 – 1371S-adenosyl-L-methionine; via carbonyl oxygen By similarity
Active sitei140 – 1401 By similarity

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB
  2. tRNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. RNA (guanine-N7)-methylation Source: GOC
  2. tRNA modification Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

RNA-binding, S-adenosyl-L-methionine, tRNA-binding

Enzyme and pathway databases

UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferase B (EC:2.1.1.33)
Alternative name(s):
Methyltransferase-like protein 1-B
tRNA (guanine(46)-N(7))-methyltransferase B
tRNA(m7G46)-methyltransferase B
Gene namesi
Name:mettl1-B
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143: Unplaced

Subcellular locationi

Nucleus By similarity UniRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 241241tRNA (guanine-N(7)-)-methyltransferase BUniRule annotationPRO_0000370561Add
BLAST

Interactioni

Subunit structurei

Forms a complex with wdr4 By similarity.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA9UMM1.
SMRiA9UMM1. Positions 27-239.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni84 – 852S-adenosyl-L-methionine binding By similarity
Regioni117 – 1182S-adenosyl-L-methionine binding By similarity
Regioni215 – 2173S-adenosyl-L-methionine binding By similarity

Sequence similaritiesi

Phylogenomic databases

KOiK03439.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_03055. tRNA_methyltr_TrmB_euk.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR025763. Trm8_euk.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9UMM1-1 [UniParc]FASTAAdd to Basket

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MSVCMPQKRY YRQRAHSNPM ADHTFQYPVC PEQMDWSPLY PQYFPQQEEA    50
GGAQVEFADI GCGYGGLLVQ LSLLFPQQLI LGLEIRVKVS DYVQDRIRSL 100
RVAEPGRYQN IACLRSNAMK YLPNFFRKGQ LSKMFFLFPD PHFKKTKHKW 150
RIISPTLLAE YAYTLRIGGL VYTNTDVEEV HEWIVQHFSD HPLFSRVTEE 200
QLADDIIVGH LGTCTEEGKK VQRNGGKNFL AVFRRVEDPQ T 241
Length:241
Mass (Da):27,951
Last modified:February 5, 2008 - v1
Checksum:i5DC526C10E4F5500
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC157713 mRNA. Translation: AAI57714.1.
RefSeqiNP_001107533.1. NM_001114061.1.
UniGeneiStr.77345.

Genome annotation databases

GeneIDi100135397.
KEGGixtr:100135397.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC157713 mRNA. Translation: AAI57714.1 .
RefSeqi NP_001107533.1. NM_001114061.1.
UniGenei Str.77345.

3D structure databases

ProteinModelPortali A9UMM1.
SMRi A9UMM1. Positions 27-239.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100135397.
KEGGi xtr:100135397.

Organism-specific databases

CTDi 100135397.

Phylogenomic databases

KOi K03439.

Enzyme and pathway databases

UniPathwayi UPA00989 .

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_03055. tRNA_methyltr_TrmB_euk.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR025763. Trm8_euk.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: TGA IC.
    Tissue: Testis.

Entry informationi

Entry nameiTRMBB_XENTR
AccessioniPrimary (citable) accession number: A9UMM1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: February 5, 2008
Last modified: June 11, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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