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Protein

Autophagy protein 5

Gene

ATG5

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in autophagic vesicle formation.UniRule annotation

GO - Biological processi

Keywordsi

Biological processAutophagyUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Autophagy protein 5UniRule annotation
Gene namesi
Name:ATG5Imported
ORF Names:hCG_32959Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Preautophagosomal structure membrane UniRule annotation; Peripheral membrane protein UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

MembraneUniRule annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24880.

PTM / Processingi

Keywords - PTMi

Isopeptide bondUniRule annotation, Ubl conjugationUniRule annotation

Expressioni

Gene expression databases

BgeeiENSG00000057663.
ExpressionAtlasiA9UGY9. baseline and differential.

Interactioni

Subunit structurei

Conjugated with ATG12.UniRule annotation

Protein-protein interaction databases

IntActiA9UGY9. 5 interactors.

Structurei

3D structure databases

SMRiA9UGY9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATG5 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2976. Eukaryota.
ENOG410XQ71. LUCA.
HOVERGENiHBG018731.
KOiK08339.
OMAiFKYIPFR.
OrthoDBiEOG091G0JU7.

Family and domain databases

InterProiView protein in InterPro
IPR007239. Atg5.
PANTHERiPTHR13040. PTHR13040. 1 hit.
PfamiView protein in Pfam
PF04106. APG5. 1 hit.

Sequencei

Sequence statusi: Complete.

A9UGY9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDDKDVLRD VWFGRIPTCF TLYQDEITER EAEPYYLLLP RVSYLTLVTD
60 70 80 90 100
KVKKHFQKVM RQEDISEIWF EYEGTPLKWH YPIGLLFDLL ASSSALPWNI
110 120 130 140 150
TVHFKSFPEK DLLHCPSKDA IEAHFMSCMK EADALKHKSQ VINEMQKKDH
160 170 180 190 200
KQLWMGLQND RFDQFWAINR KLMEYPAEEN GFRYIPFRIY QTTTERPFIQ
210 220 230 240 250
KLFRPVAADG QLHTLGDLLK EVCPSAIDPE DGEKKNQVMI HGIEPMLETP
260 270
LQWLSEHLSY PDNFLHISII PQPTD
Length:275
Mass (Da):32,447
Last modified:February 5, 2008 - v1
Checksum:iC33A1E0B3C1DBE5C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU283339 mRNA. Translation: ABX79918.1.
JQ924061 mRNA. Translation: AGC52703.1.
CH471051 Genomic DNA. Translation: EAW48415.1.
CH471051 Genomic DNA. Translation: EAW48416.1.
CH471051 Genomic DNA. Translation: EAW48418.1.
RefSeqiNP_001273035.1. NM_001286106.1.
NP_004840.1. NM_004849.3.
UniGeneiHs.486063.

Genome annotation databases

GeneIDi9474.
KEGGihsa:9474.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiA9UGY9_HUMAN
AccessioniPrimary (citable) accession number: A9UGY9
Entry historyiIntegrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: July 5, 2017
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.