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A9UGY9

- A9UGY9_HUMAN

UniProt

A9UGY9 - A9UGY9_HUMAN

Protein
Submitted name:

ATG5

Gene

ATG5

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (05 Feb 2008)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. autophagic vacuole assembly Source: Ensembl
    2. blood vessel remodeling Source: Ensembl
    3. heart contraction Source: Ensembl
    4. negative regulation of apoptotic process Source: Ensembl
    5. negative regulation of protein ubiquitination Source: Ensembl
    6. otolith development Source: Ensembl
    7. post-translational protein modification Source: Ensembl
    8. regulation of cytokine secretion involved in immune response Source: Ensembl
    9. response to drug Source: Ensembl
    10. response to fungus Source: Ensembl
    11. vasodilation Source: Ensembl
    12. ventricular cardiac muscle cell development Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    ATG5Imported
    Submitted name:
    ATG5 autophagy related 5 homolog (S. cerevisiae), isoform CRA_bImported
    Submitted name:
    ATG5 autophagy related 5-likeImported
    Gene namesi
    Name:ATG5Imported
    ORF Names:hCG_32959Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. autophagic vacuole Source: Ensembl
    2. pre-autophagosomal structure membrane Source: Ensembl

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA24880.

    Structurei

    3D structure databases

    SMRiA9UGY9. Positions 3-275.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    HOVERGENiHBG018731.
    KOiK08339.
    OMAiHYPIGVL.
    PhylomeDBiA9UGY9.

    Family and domain databases

    InterProiIPR007239. Atg5.
    [Graphical view]
    PANTHERiPTHR13040. PTHR13040. 1 hit.
    PfamiPF04106. APG5. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A9UGY9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTDDKDVLRD VWFGRIPTCF TLYQDEITER EAEPYYLLLP RVSYLTLVTD    50
    KVKKHFQKVM RQEDISEIWF EYEGTPLKWH YPIGLLFDLL ASSSALPWNI 100
    TVHFKSFPEK DLLHCPSKDA IEAHFMSCMK EADALKHKSQ VINEMQKKDH 150
    KQLWMGLQND RFDQFWAINR KLMEYPAEEN GFRYIPFRIY QTTTERPFIQ 200
    KLFRPVAADG QLHTLGDLLK EVCPSAIDPE DGEKKNQVMI HGIEPMLETP 250
    LQWLSEHLSY PDNFLHISII PQPTD 275
    Length:275
    Mass (Da):32,447
    Last modified:February 5, 2008 - v1
    Checksum:iC33A1E0B3C1DBE5C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EU283339 mRNA. Translation: ABX79918.1.
    JQ924061 mRNA. Translation: AGC52703.1.
    CH471051 Genomic DNA. Translation: EAW48415.1.
    CH471051 Genomic DNA. Translation: EAW48416.1.
    CH471051 Genomic DNA. Translation: EAW48418.1.
    RefSeqiNP_001273035.1. NM_001286106.1.
    NP_004840.1. NM_004849.3.
    UniGeneiHs.486063.

    Genome annotation databases

    GeneIDi9474.
    KEGGihsa:9474.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EU283339 mRNA. Translation: ABX79918.1 .
    JQ924061 mRNA. Translation: AGC52703.1 .
    CH471051 Genomic DNA. Translation: EAW48415.1 .
    CH471051 Genomic DNA. Translation: EAW48416.1 .
    CH471051 Genomic DNA. Translation: EAW48418.1 .
    RefSeqi NP_001273035.1. NM_001286106.1.
    NP_004840.1. NM_004849.3.
    UniGenei Hs.486063.

    3D structure databases

    SMRi A9UGY9. Positions 3-275.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    DNASUi 9474.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 9474.
    KEGGi hsa:9474.

    Organism-specific databases

    CTDi 9474.
    PharmGKBi PA24880.

    Phylogenomic databases

    HOVERGENi HBG018731.
    KOi K08339.
    OMAi HYPIGVL.
    PhylomeDBi A9UGY9.

    Miscellaneous databases

    ChiTaRSi ATG5. human.
    GenomeRNAii 9474.
    NextBioi 35504.

    Family and domain databases

    InterProi IPR007239. Atg5.
    [Graphical view ]
    PANTHERi PTHR13040. PTHR13040. 1 hit.
    Pfami PF04106. APG5. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The sequence of the human genome."
      Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G., Smith H.O., Yandell M., Evans C.A., Holt R.A., Gocayne J.D., Amanatides P., Ballew R.M., Huson D.H., Wortman J.R., Zhang Q., Kodira C.D., Zheng X.H.
      , Chen L., Skupski M., Subramanian G., Thomas P.D., Zhang J., Gabor Miklos G.L., Nelson C., Broder S., Clark A.G., Nadeau J., McKusick V.A., Zinder N., Levine A.J., Roberts R.J., Simon M., Slayman C., Hunkapiller M., Bolanos R., Delcher A., Dew I., Fasulo D., Flanigan M., Florea L., Halpern A., Hannenhalli S., Kravitz S., Levy S., Mobarry C., Reinert K., Remington K., Abu-Threideh J., Beasley E., Biddick K., Bonazzi V., Brandon R., Cargill M., Chandramouliswaran I., Charlab R., Chaturvedi K., Deng Z., Di Francesco V., Dunn P., Eilbeck K., Evangelista C., Gabrielian A.E., Gan W., Ge W., Gong F., Gu Z., Guan P., Heiman T.J., Higgins M.E., Ji R.R., Ke Z., Ketchum K.A., Lai Z., Lei Y., Li Z., Li J., Liang Y., Lin X., Lu F., Merkulov G.V., Milshina N., Moore H.M., Naik A.K., Narayan V.A., Neelam B., Nusskern D., Rusch D.B., Salzberg S., Shao W., Shue B., Sun J., Wang Z., Wang A., Wang X., Wang J., Wei M., Wides R., Xiao C., Yan C., Yao A., Ye J., Zhan M., Zhang W., Zhang H., Zhao Q., Zheng L., Zhong F., Zhong W., Zhu S., Zhao S., Gilbert D., Baumhueter S., Spier G., Carter C., Cravchik A., Woodage T., Ali F., An H., Awe A., Baldwin D., Baden H., Barnstead M., Barrow I., Beeson K., Busam D., Carver A., Center A., Cheng M.L., Curry L., Danaher S., Davenport L., Desilets R., Dietz S., Dodson K., Doup L., Ferriera S., Garg N., Gluecksmann A., Hart B., Haynes J., Haynes C., Heiner C., Hladun S., Hostin D., Houck J., Howland T., Ibegwam C., Johnson J., Kalush F., Kline L., Koduru S., Love A., Mann F., May D., McCawley S., McIntosh T., McMullen I., Moy M., Moy L., Murphy B., Nelson K., Pfannkoch C., Pratts E., Puri V., Qureshi H., Reardon M., Rodriguez R., Rogers Y.H., Romblad D., Ruhfel B., Scott R., Sitter C., Smallwood M., Stewart E., Strong R., Suh E., Thomas R., Tint N.N., Tse S., Vech C., Wang G., Wetter J., Williams S., Williams M., Windsor S., Winn-Deen E., Wolfe K., Zaveri J., Zaveri K., Abril J.F., Guigo R., Campbell M.J., Sjolander K.V., Karlak B., Kejariwal A., Mi H., Lazareva B., Hatton T., Narechania A., Diemer K., Muruganujan A., Guo N., Sato S., Bafna V., Istrail S., Lippert R., Schwartz R., Walenz B., Yooseph S., Allen D., Basu A., Baxendale J., Blick L., Caminha M., Carnes-Stine J., Caulk P., Chiang Y.H., Coyne M., Dahlke C., Mays A., Dombroski M., Donnelly M., Ely D., Esparham S., Fosler C., Gire H., Glanowski S., Glasser K., Glodek A., Gorokhov M., Graham K., Gropman B., Harris M., Heil J., Henderson S., Hoover J., Jennings D., Jordan C., Jordan J., Kasha J., Kagan L., Kraft C., Levitsky A., Lewis M., Liu X., Lopez J., Ma D., Majoros W., McDaniel J., Murphy S., Newman M., Nguyen T., Nguyen N., Nodell M., Pan S., Peck J., Peterson M., Rowe W., Sanders R., Scott J., Simpson M., Smith T., Sprague A., Stockwell T., Turner R., Venter E., Wang M., Wen M., Wu D., Wu M., Xia A., Zandieh A., Zhu X.
      Science 291:1304-1351(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE.
    3. "Expression of autophagy related genes in human CD14 cells infected with Streptococcus pyogenes."
      Mayo K., Miller K., Hakami R., Ulrich R., Elliott L.H.
      Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    4. "Cloning of cDNA of autophagy-related genes from human prostate cancer cell lines."
      Xu L.-H., Ouyang D.-Y., He X.-H.
      Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiA9UGY9_HUMAN
    AccessioniPrimary (citable) accession number: A9UGY9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 5, 2008
    Last sequence update: February 5, 2008
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.