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A9UGY9

- A9UGY9_HUMAN

UniProt

A9UGY9 - A9UGY9_HUMAN

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Protein

Autophagy protein 5

Gene

ATG5

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Involved in autophagic vesicle formation.UniRule annotation

GO - Biological processi

  1. autophagic vacuole assembly Source: Ensembl
  2. blood vessel remodeling Source: Ensembl
  3. heart contraction Source: Ensembl
  4. negative regulation of apoptotic process Source: Ensembl
  5. negative regulation of protein ubiquitination Source: Ensembl
  6. negative stranded viral RNA replication Source: Ensembl
  7. otolith development Source: Ensembl
  8. post-translational protein modification Source: Ensembl
  9. regulation of cilium assembly Source: Ensembl
  10. regulation of cytokine secretion involved in immune response Source: Ensembl
  11. response to drug Source: Ensembl
  12. response to fungus Source: Ensembl
  13. vasodilation Source: Ensembl
  14. ventricular cardiac muscle cell development Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

AutophagyUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Autophagy protein 5UniRule annotation
Gene namesi
Name:ATG5Imported
ORF Names:hCG_32959Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Preautophagosomal structure membrane UniRule annotation; Peripheral membrane protein UniRule annotation

GO - Cellular componenti

  1. autophagic vacuole Source: Ensembl
  2. axoneme Source: Ensembl
  3. pre-autophagosomal structure membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

MembraneUniRule annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24880.

PTM / Processingi

Keywords - PTMi

Isopeptide bondUniRule annotation, Ubl conjugationUniRule annotation

Expressioni

Gene expression databases

ExpressionAtlasiA9UGY9. baseline and differential.

Interactioni

Subunit structurei

Conjugated with ATG12.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA9UGY9.
SMRiA9UGY9. Positions 3-275.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATG5 family.UniRule annotation

Phylogenomic databases

HOVERGENiHBG018731.
KOiK08339.
OMAiHYPIGVL.
PhylomeDBiA9UGY9.

Family and domain databases

InterProiIPR007239. Atg5.
[Graphical view]
PANTHERiPTHR13040. PTHR13040. 1 hit.
PfamiPF04106. APG5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9UGY9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTDDKDVLRD VWFGRIPTCF TLYQDEITER EAEPYYLLLP RVSYLTLVTD
60 70 80 90 100
KVKKHFQKVM RQEDISEIWF EYEGTPLKWH YPIGLLFDLL ASSSALPWNI
110 120 130 140 150
TVHFKSFPEK DLLHCPSKDA IEAHFMSCMK EADALKHKSQ VINEMQKKDH
160 170 180 190 200
KQLWMGLQND RFDQFWAINR KLMEYPAEEN GFRYIPFRIY QTTTERPFIQ
210 220 230 240 250
KLFRPVAADG QLHTLGDLLK EVCPSAIDPE DGEKKNQVMI HGIEPMLETP
260 270
LQWLSEHLSY PDNFLHISII PQPTD
Length:275
Mass (Da):32,447
Last modified:February 5, 2008 - v1
Checksum:iC33A1E0B3C1DBE5C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EU283339 mRNA. Translation: ABX79918.1.
JQ924061 mRNA. Translation: AGC52703.1.
CH471051 Genomic DNA. Translation: EAW48415.1.
CH471051 Genomic DNA. Translation: EAW48416.1.
CH471051 Genomic DNA. Translation: EAW48418.1.
RefSeqiNP_001273035.1. NM_001286106.1.
NP_004840.1. NM_004849.3.
UniGeneiHs.486063.

Genome annotation databases

GeneIDi9474.
KEGGihsa:9474.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EU283339 mRNA. Translation: ABX79918.1 .
JQ924061 mRNA. Translation: AGC52703.1 .
CH471051 Genomic DNA. Translation: EAW48415.1 .
CH471051 Genomic DNA. Translation: EAW48416.1 .
CH471051 Genomic DNA. Translation: EAW48418.1 .
RefSeqi NP_001273035.1. NM_001286106.1.
NP_004840.1. NM_004849.3.
UniGenei Hs.486063.

3D structure databases

ProteinModelPortali A9UGY9.
SMRi A9UGY9. Positions 3-275.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

DNASUi 9474.
Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 9474.
KEGGi hsa:9474.

Organism-specific databases

CTDi 9474.
PharmGKBi PA24880.

Phylogenomic databases

HOVERGENi HBG018731.
KOi K08339.
OMAi HYPIGVL.
PhylomeDBi A9UGY9.

Miscellaneous databases

ChiTaRSi ATG5. human.
GenomeRNAii 9474.
NextBioi 35504.

Gene expression databases

ExpressionAtlasi A9UGY9. baseline and differential.

Family and domain databases

InterProi IPR007239. Atg5.
[Graphical view ]
PANTHERi PTHR13040. PTHR13040. 1 hit.
Pfami PF04106. APG5. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The sequence of the human genome."
    Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G., Smith H.O., Yandell M., Evans C.A., Holt R.A., Gocayne J.D., Amanatides P., Ballew R.M., Huson D.H., Wortman J.R., Zhang Q., Kodira C.D., Zheng X.H.
    , Chen L., Skupski M., Subramanian G., Thomas P.D., Zhang J., Gabor Miklos G.L., Nelson C., Broder S., Clark A.G., Nadeau J., McKusick V.A., Zinder N., Levine A.J., Roberts R.J., Simon M., Slayman C., Hunkapiller M., Bolanos R., Delcher A., Dew I., Fasulo D., Flanigan M., Florea L., Halpern A., Hannenhalli S., Kravitz S., Levy S., Mobarry C., Reinert K., Remington K., Abu-Threideh J., Beasley E., Biddick K., Bonazzi V., Brandon R., Cargill M., Chandramouliswaran I., Charlab R., Chaturvedi K., Deng Z., Di Francesco V., Dunn P., Eilbeck K., Evangelista C., Gabrielian A.E., Gan W., Ge W., Gong F., Gu Z., Guan P., Heiman T.J., Higgins M.E., Ji R.R., Ke Z., Ketchum K.A., Lai Z., Lei Y., Li Z., Li J., Liang Y., Lin X., Lu F., Merkulov G.V., Milshina N., Moore H.M., Naik A.K., Narayan V.A., Neelam B., Nusskern D., Rusch D.B., Salzberg S., Shao W., Shue B., Sun J., Wang Z., Wang A., Wang X., Wang J., Wei M., Wides R., Xiao C., Yan C., Yao A., Ye J., Zhan M., Zhang W., Zhang H., Zhao Q., Zheng L., Zhong F., Zhong W., Zhu S., Zhao S., Gilbert D., Baumhueter S., Spier G., Carter C., Cravchik A., Woodage T., Ali F., An H., Awe A., Baldwin D., Baden H., Barnstead M., Barrow I., Beeson K., Busam D., Carver A., Center A., Cheng M.L., Curry L., Danaher S., Davenport L., Desilets R., Dietz S., Dodson K., Doup L., Ferriera S., Garg N., Gluecksmann A., Hart B., Haynes J., Haynes C., Heiner C., Hladun S., Hostin D., Houck J., Howland T., Ibegwam C., Johnson J., Kalush F., Kline L., Koduru S., Love A., Mann F., May D., McCawley S., McIntosh T., McMullen I., Moy M., Moy L., Murphy B., Nelson K., Pfannkoch C., Pratts E., Puri V., Qureshi H., Reardon M., Rodriguez R., Rogers Y.H., Romblad D., Ruhfel B., Scott R., Sitter C., Smallwood M., Stewart E., Strong R., Suh E., Thomas R., Tint N.N., Tse S., Vech C., Wang G., Wetter J., Williams S., Williams M., Windsor S., Winn-Deen E., Wolfe K., Zaveri J., Zaveri K., Abril J.F., Guigo R., Campbell M.J., Sjolander K.V., Karlak B., Kejariwal A., Mi H., Lazareva B., Hatton T., Narechania A., Diemer K., Muruganujan A., Guo N., Sato S., Bafna V., Istrail S., Lippert R., Schwartz R., Walenz B., Yooseph S., Allen D., Basu A., Baxendale J., Blick L., Caminha M., Carnes-Stine J., Caulk P., Chiang Y.H., Coyne M., Dahlke C., Mays A., Dombroski M., Donnelly M., Ely D., Esparham S., Fosler C., Gire H., Glanowski S., Glasser K., Glodek A., Gorokhov M., Graham K., Gropman B., Harris M., Heil J., Henderson S., Hoover J., Jennings D., Jordan C., Jordan J., Kasha J., Kagan L., Kraft C., Levitsky A., Lewis M., Liu X., Lopez J., Ma D., Majoros W., McDaniel J., Murphy S., Newman M., Nguyen T., Nguyen N., Nodell M., Pan S., Peck J., Peterson M., Rowe W., Sanders R., Scott J., Simpson M., Smith T., Sprague A., Stockwell T., Turner R., Venter E., Wang M., Wen M., Wu D., Wu M., Xia A., Zandieh A., Zhu X.
    Science 291:1304-1351(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE.
  3. "Expression of autophagy related genes in human CD14 cells infected with Streptococcus pyogenes."
    Mayo K., Miller K., Hakami R., Ulrich R., Elliott L.H.
    Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  4. "Cloning of cDNA of autophagy-related genes from human prostate cancer cell lines."
    Xu L.-H., Ouyang D.-Y., He X.-H.
    Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiA9UGY9_HUMAN
AccessioniPrimary (citable) accession number: A9UGY9
Entry historyi
Integrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: October 29, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.