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Protein
Submitted name:

Low affinity neurotrophin p75 receptor

Gene

NGFR

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

ReceptorImported

Names & Taxonomyi

Protein namesi
Submitted name:
Low affinity neurotrophin p75 receptorImported
Gene namesi
Name:NGFRImported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei239 – 25921HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Chaini20 – 414395Sequence analysisPRO_5002744598Add
BLAST

Proteomic databases

PaxDbiA9UGK7.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000020402.

Structurei

3D structure databases

ProteinModelPortaliA9UGK7.
SMRiA9UGK7. Positions 22-178, 320-407.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini56 – 9742TNFR-CysInterPro annotationAdd
BLAST
Domaini98 – 13639TNFR-CysInterPro annotationAdd
BLAST
Domaini138 – 17841TNFR-CysInterPro annotationAdd
BLAST
Domaini331 – 40878DeathInterPro annotationAdd
BLAST

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IQFC. Eukaryota.
ENOG4111F3C. LUCA.
HOVERGENiHBG060431.
KOiK02583.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
InterProiIPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR001368. TNFR/NGFR_Cys_rich_reg.
IPR022325. TNFR_16.
[Graphical view]
PfamiPF00531. Death. 1 hit.
PF00020. TNFR_c6. 2 hits.
[Graphical view]
PRINTSiPR01966. TNFACTORR16.
SMARTiSM00005. DEATH. 1 hit.
SM00208. TNFR. 4 hits.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiPS50017. DEATH_DOMAIN. 1 hit.
PS00652. TNFR_NGFR_1. 3 hits.
PS50050. TNFR_NGFR_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9UGK7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGFVPLLLL LLPAGPTWGS KCLTKMYTTS GECCKACNLG EGVVQPCGVN
60 70 80 90 100
QTVCEPCLDS VTYSDTVSAT EPCKPCTQCV GLHSMSAPCV ESDDAVCRCA
110 120 130 140 150
YGYFQDELSG SCKECSICEV GFGLMFPCRD SQDTVCEECP EGTFSDEANF
160 170 180 190 200
VDPCLPCTIC EENEVMVKEC TATSDAECRD LHPRWTTHTP SLAGSDSPEP
210 220 230 240 250
ITRDPFNTEG MATTLADIVT TVMGSSQPVV SRGTADNLIP VYCSILAAVV
260 270 280 290 300
VGLVAYIAFK RWNSCKQNKQ GANNRPVNQT PSPEGEKLHS DSGISVDSQS
310 320 330 340 350
LHDQQPPNQS TQGPAPKGDG SLYASLPPSK QEEVEKLLSS SAEETWRQLA
360 370 380 390 400
GELGYKEDLI DCFTREESPA RALLADWSAK ETATLDALLV ALRKIQRGDI
410
AESLYSESTA TSPV
Length:414
Mass (Da):44,397
Last modified:February 5, 2008 - v1
Checksum:i9756A14396F43673
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU282004 mRNA. Translation: ABX79794.1.
RefSeqiNP_001139605.1. NM_001146133.1.
UniGeneiGga.39799.

Genome annotation databases

GeneIDi425805.
KEGGigga:425805.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU282004 mRNA. Translation: ABX79794.1.
RefSeqiNP_001139605.1. NM_001146133.1.
UniGeneiGga.39799.

3D structure databases

ProteinModelPortaliA9UGK7.
SMRiA9UGK7. Positions 22-178, 320-407.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000020402.

Proteomic databases

PaxDbiA9UGK7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi425805.
KEGGigga:425805.

Organism-specific databases

CTDi4804.

Phylogenomic databases

eggNOGiENOG410IQFC. Eukaryota.
ENOG4111F3C. LUCA.
HOVERGENiHBG060431.
KOiK02583.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
InterProiIPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR001368. TNFR/NGFR_Cys_rich_reg.
IPR022325. TNFR_16.
[Graphical view]
PfamiPF00531. Death. 1 hit.
PF00020. TNFR_c6. 2 hits.
[Graphical view]
PRINTSiPR01966. TNFACTORR16.
SMARTiSM00005. DEATH. 1 hit.
SM00208. TNFR. 4 hits.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiPS50017. DEATH_DOMAIN. 1 hit.
PS00652. TNFR_NGFR_1. 3 hits.
PS50050. TNFR_NGFR_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Fates of neurotrophins after retrograde axonal transport: phosphorylation of p75NTR is a sorting signal for delayed degradation."
    Butowt R., von Bartheld C.S.
    J. Neurosci. 29:10715-10729(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: RetinaImported.

Entry informationi

Entry nameiA9UGK7_CHICK
AccessioniPrimary (citable) accession number: A9UGK7
Entry historyi
Integrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: June 8, 2016
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.