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Protein
Submitted name:

BCR/ABL fusion protein isoform Y5

Gene

BCR/ABL fusion

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.SAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinaseSAAS annotation

Keywords - Ligandi

ATP-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiA9UF07.
SIGNORiA9UF07.

Names & Taxonomyi

Protein namesi
Submitted name:
BCR/ABL fusion protein isoform Y5Imported
Gene namesi
Name:BCR/ABL fusionImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

PTM / Processingi

Proteomic databases

PaxDbiA9UF07.
PeptideAtlasiA9UF07.
PRIDEiA9UF07.

PTM databases

iPTMnetiA9UF07.
PhosphoSitePlusiA9UF07.

Interactioni

Protein-protein interaction databases

IntActiA9UF07. 16 interactors.
STRINGi9606.ENSP00000361423.

Structurei

3D structure databases

ProteinModelPortaliA9UF07.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini467 – 625PHInterPro annotationAdd BLAST159
Domaini721 – 781SH3InterPro annotationAdd BLAST61
Domaini787 – 877SH2InterPro annotationAdd BLAST91
Domaini902 – 1153Protein kinaseInterPro annotationAdd BLAST252

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili28 – 55Sequence analysisAdd BLAST28

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.SAAS annotation
Contains 1 SH3 domain.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, SH3 domainUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0197. Eukaryota.
COG0515. LUCA.
HOGENOMiHOG000231988.
HOVERGENiHBG004162.

Family and domain databases

Gene3Di2.30.29.30. 2 hits.
3.30.505.10. 1 hit.
4.10.280.30. 1 hit.
InterProiIPR033221. ABL1.
IPR015123. Bcr-Abl_oncoprot_oligo.
IPR015015. F-actin_binding.
IPR011009. Kinase-like_dom.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PANTHERiPTHR24418:SF88. PTHR24418:SF88. 1 hit.
PfamiPF09036. Bcr-Abl_Oligo. 1 hit.
PF08919. F_actin_bind. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00109. TYRKINASE.
SMARTiSM00808. FABD. 1 hit.
SM00233. PH. 1 hit.
SM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF50729. SSF50729. 2 hits.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
SSF69036. SSF69036. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9UF07-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVDPVGFAEA WKAQFPDSEP PRMELRSVGD IEQELERCKA SIRRLEQEVN
60 70 80 90 100
QERFRMIYLQ TLLAKEKKSY DRQRWGFRRA AQAPDGASEP RASASRPQPA
110 120 130 140 150
PADGADPPPA EEPEARPDGE GSPGKARPGT ARRPGAAASG ERDDRGPPAS
160 170 180 190 200
VAALRSNFER IRKGHGQPGA DAEKPFYVNV EFHHERGLVK VNDKEVSDRI
210 220 230 240 250
SSLGSQAMQM ERKKSQHGAG SSVGDASRPP YRGRSSESSC GVDGDYEDAE
260 270 280 290 300
LNPRFLKDNL IDANGGSRPP WPPLEYQPYQ SIYVGGMMEG EGKGPLLRSQ
310 320 330 340 350
STSEQEKRLT WPRRSYSPRS FEDCGGGYTP DCSSNENLTS SEEDFSSGQS
360 370 380 390 400
SRVSPSPTTY RMFRDKSRSP SQNSQQSFDS SSPPTPQCHK RHRHCPVVVS
410 420 430 440 450
EATIVGVRKT GQIWPNDGEG AFHGDADGSF GTPPGYGCAA DRAEEQRRHQ
460 470 480 490 500
DGLPYIDDSP SSSPHRQLLK DSFMVELVEG ARKLRHVFLF TDLLLCTKLK
510 520 530 540 550
KQSGGKTQQY DCKWYIPLTD LSFQMVDELE AVPNIPLVPD EELDALKIKI
560 570 580 590 600
SQIKSDIQRE KRANKGSKAT ERLKKKLSEQ ESLLLLMSPS MAFRVHSRNG
610 620 630 640 650
KSYTFLISSD YERAEWRENI REQQKKCFRS FSLTSVELQM LTNSCVKLQT
660 670 680 690 700
VHSIPLTINK EDDESPGLYG FLNVIVHSAT GFKQSSKALQ RPVASDFEPQ
710 720 730 740 750
GLSEAARWNS KENLLAGPSE NDPNLFVALY DFVASGDNTL SITKGEKLRV
760 770 780 790 800
LGYNHNGEWC EAQTKNGQGW VPSNYITPVN SLEKHSWYHG PVSRNAAEYL
810 820 830 840 850
LSSGINGSFL VRESESSPGQ RSISLRYEGR VYHYRINTAS DGKLYVSSES
860 870 880 890 900
RFNTLAELVH HHSTVADGLI TTLHYPAPKR NKPTVYGVSP NYDKWEMERT
910 920 930 940 950
DITMKHKLGG GQYGEVYEGV WKKYSLTVAV KTLKEDTMEV EEFLKEAAVM
960 970 980 990 1000
KEIKHPNLVQ LLGVCTREPP FYIITEFMTY GNLLDYLREC NRQEVNAVVL
1010 1020 1030 1040 1050
LYMATQISSA MEYLEKKNFI HRDLAARNCL VGENHLVKVA DFGLSRLMTG
1060 1070 1080 1090 1100
DTYTAHAGAK FPIKWTAPES LAYNKFSIKS DVWAFGVLLW EIATYGMSPY
1110 1120 1130 1140 1150
PGIDLSQVYE LLEKDYRMER PEGCPEKVYE LMRACWQWNP SDRPSFAEIH
1160 1170 1180 1190 1200
QAFETMFQES SISDEVEKEL GKQGVRGAVS TLLQAPELPT KTRTSRRAAE
1210 1220 1230 1240 1250
HRDTTDVPEM PHSKGQGESD PLDHEPAVSP LLPRKERGPP EGGLNEDERL
1260 1270 1280 1290 1300
LPKDKKTNLF SALIKKKKKT APTPPKRSSS FREMDGQPER RGAGEEEGRD
1310 1320 1330 1340 1350
ISNGALAFTP LDTADPAKSP KPSNGAGVPN GALRESGGSG FRSPHLWKKS
1360 1370 1380 1390 1400
STLTSSRLAT GEEEGGGSSS KRFLRSCSAS CVPHGAKDTE WRSVTLPRDL
1410 1420 1430 1440 1450
QSTGRQFDSS TFGGHKSEKP ALPRKRAGEN RSDQVTRGTV TPPPRLVKKN
1460 1470 1480 1490 1500
EEAADEVFKD IMESSPGSSP PNLTPKPLRR QVTVAPASGL PHKEEAGKGS
1510 1520 1530 1540 1550
ALGTPAAAEP VTPTSKAGSG APGGTSKGPA EESRVRRHKH SSESPGRDKG
1560 1570 1580 1590 1600
KLSRLKPAPP PPPAASAGKA GGKPSQSPSQ EAAGEAVLGA KTKATSLVDA
1610 1620 1630 1640 1650
VNSDAAKPSQ PGEGLKKPVL PATPKPQSAK PSGTPISPAP VPSTLPSASS
1660 1670 1680 1690 1700
ALAGDQPSST AFIPLISTRV SLRKTRQPPE RIASGAITKG VVLDSTEALC
1710 1720 1730 1740 1750
LAISRNSEQM ASHSAVLEAG KNLYTFCVSY VDSIQQMRNK FAFREAINKL
1760 1770 1780 1790
ENNLRELQIC PATAGSGPAA TQDFSKLLSS VKEISDIVQR
Length:1,790
Mass (Da):196,572
Last modified:February 5, 2008 - v1
Checksum:iCB55E0968F4FDAAE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU216071 mRNA. Translation: ABX82713.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU216071 mRNA. Translation: ABX82713.1.

3D structure databases

ProteinModelPortaliA9UF07.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiA9UF07. 16 interactors.
STRINGi9606.ENSP00000361423.

PTM databases

iPTMnetiA9UF07.
PhosphoSitePlusiA9UF07.

Proteomic databases

PaxDbiA9UF07.
PeptideAtlasiA9UF07.
PRIDEiA9UF07.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG0197. Eukaryota.
COG0515. LUCA.
HOGENOMiHOG000231988.
HOVERGENiHBG004162.

Enzyme and pathway databases

SignaLinkiA9UF07.
SIGNORiA9UF07.

Miscellaneous databases

ChiTaRSiABL1. human.

Family and domain databases

Gene3Di2.30.29.30. 2 hits.
3.30.505.10. 1 hit.
4.10.280.30. 1 hit.
InterProiIPR033221. ABL1.
IPR015123. Bcr-Abl_oncoprot_oligo.
IPR015015. F-actin_binding.
IPR011009. Kinase-like_dom.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PANTHERiPTHR24418:SF88. PTHR24418:SF88. 1 hit.
PfamiPF09036. Bcr-Abl_Oligo. 1 hit.
PF08919. F_actin_bind. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00109. TYRKINASE.
SMARTiSM00808. FABD. 1 hit.
SM00233. PH. 1 hit.
SM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF50729. SSF50729. 2 hits.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
SSF69036. SSF69036. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiA9UF07_HUMAN
AccessioniPrimary (citable) accession number: A9UF07
Entry historyi
Integrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: November 30, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.