A9UF02 (A9UF02_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
BCR/ABL fusion protein isoform X9 EMBL ABX82708.1

Gene names

Name:

BCR/ABL fusion EMBL ABX82708.1

Organism

Homo sapiens (Human) EMBL ABX82708.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1644 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. SAAS SAAS008266
Sequence similarities	Contains 1 SH2 domain. SAAS SAAS008266 Contains 1 SH3 domain. RuleBase RU003338 SAAS SAAS008266 Contains 1 protein kinase domain. SAAS SAAS008266

Ontologies

Keywords
Domain	SH3 domain RuleBase RU003338 SAAS SAAS008266
Ligand	ATP-binding SAAS SAAS008266 Nucleotide-binding
Molecular function	Kinase Transferase Tyrosine-protein kinase SAAS SAAS008266
Gene Ontology (GO)
Biological_process	positive regulation of GTPase activity Inferred from electronic annotation. Source: GOC signal transduction Inferred from electronic annotation. Source: InterPro
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW GTPase activator activity Inferred from electronic annotation. Source: InterPro non-membrane spanning protein tyrosine kinase activity Inferred from electronic annotation. Source: InterPro protein serine/threonine kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A9UF02 [UniParc]. Last modified February 5, 2008. Version 1. Checksum: EAF7473B10174EB4	FASTA	1,644	179,323
	10 20 30 40 50 60 MVDPVGFAEA WKAQFPDSEP PRMELRSVGD IEQELERCKA SIRRLEQEVN QERFRMIYLQ 70 80 90 100 110 120 TLLAKEKKSY DRQRWGFRRA AQAPDGASEP RASASRPQPA PADGADPPPA EEPEARPDGE 130 140 150 160 170 180 GSPGKARPGT ARRPGAAASG ERDDRGPPAS VAALRSNFER IRKGHGQPGA DAEKPFYVNV 190 200 210 220 230 240 EFHHERGLVK VNDKEVSDRI SSLGSQAMQM ERKKSQHGAG SSVGDASRPP YRGRSSESSC 250 260 270 280 290 300 GVDGDYEDAE LNPRFLKDNL IDANGGSRPP WPPLEYQPYQ SIYVGGMMEG EGKGPLLRSQ 310 320 330 340 350 360 STSEQEKRLT WPRRSYSPRS FEDCGGGYTP DCSSNENLTS SEEDFSSGQS SRVSPSPTTY 370 380 390 400 410 420 RMFRDKSRSP SQNSQQSFDS SSPPTPQCHK RHRHCPVVVS EATIVGVRKT GQIWPNDGEG 430 440 450 460 470 480 AFHGDADGSF GTPPGYGCAA DRAEEQRRHQ DGLPYIDDSP SSSPHLSSKG RGSRDALVSG 490 500 510 520 530 540 ALESTKASEL DLEKGLEMRK WVLSGILASE ETYLSHLQML TNSCVKLQTV HSIPLTINKE 550 560 570 580 590 600 EALQRPVASD FEPQGLSEAA RWNSKENLLA GPSENDPNLF VALYDFVASG DNTLSITKGE 610 620 630 640 650 660 KLRVLGYNHN GEWCEAQTKN GQGWVPSNYI TPVNSLEKHS WYHGPVSRNA AEYLLSSGIN 670 680 690 700 710 720 GSFLVRESES SPGQRSISLR YEGRVYHYRI NTASDGKLYV SSESRFNTLA ELVHHHSTVA 730 740 750 760 770 780 DGLITTLHYP APKRNKPTVY GVSPNYDKWE MERTDITMKH KLGGGQYGEV YEGVWKKYSL 790 800 810 820 830 840 TVAVKTLKED TMEVEEFLKE AAVMKEIKHP NLVQLLGVCT REPPFYIITE FMTYGNLLDY 850 860 870 880 890 900 LRECNRQEVN AVVLLYMATQ ISSAMEYLEK KNFIHRDLAA RNCLVGENHL VKVADFGLSR 910 920 930 940 950 960 LMTGDTYTAH AGAKFPIKWT APESLAYNKF SIKSDVWAFG VLLWEIATYG MSPYPGIDLS 970 980 990 1000 1010 1020 QVYELLEKDY RMERPEGCPE KVYELMRACW QWNPSDRPSF AEIHQAFETM FQESSISDEV 1030 1040 1050 1060 1070 1080 EKELGKQGVR GAVSTLLQAP ELPTKTRTSR RAAEHRDTTD VPEMPHSKGQ GESDPLDHEP 1090 1100 1110 1120 1130 1140 AVSPLLPRKE RGPPEGGLNE DERLLPKDKK TNLFSALIKK KKKTAPTPPK RSSSFREMDG 1150 1160 1170 1180 1190 1200 QPERRGAGEE EGRDISNGAL AFTPLDTADP AKSPKPSNGA GVPNGALRES GGSGFRSPHL 1210 1220 1230 1240 1250 1260 WKKSSTLTSS RLATGEEEGG GSSSKRFLRS CSASCVPHGA KDTEWRSVTL PRDLQSTGRQ 1270 1280 1290 1300 1310 1320 FDSSTFGGHK SEKPALPRKR AGENRSDQVT RGTVTPPPRL VKKNEEAADE VFKDIMESSP 1330 1340 1350 1360 1370 1380 GSSPPNLTPK PLRRQVTVAP ASGLPHKEEA GKGSALGTPA AAEPVTPTSK AGSGAPGGTS 1390 1400 1410 1420 1430 1440 KGPAEESRVR RHKHSSESPG RDKGKLSRLK PAPPPPPAAS AGKAGGKPSQ SPSQEAAGEA 1450 1460 1470 1480 1490 1500 VLGAKTKATS LVDAVNSDAA KPSQPGEGLK KPVLPATPKP QSAKPSGTPI SPAPVPSTLP 1510 1520 1530 1540 1550 1560 SASSALAGDQ PSSTAFIPLI STRVSLRKTR QPPERIASGA ITKGVVLDST EALCLAISRN 1570 1580 1590 1600 1610 1620 SEQMASHSAV LEAGKNLYTF CVSYVDSIQQ MRNKFAFREA INKLENNLRE LQICPATAGS 1630 1640 GPAATQDFSK LLSSVKEISD IVQR

References

[1]	"Frequency and clinical impact of atypical BCR/ABL transcripts in chronic myeloid leukemia." Tzen C.-Y. Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.

Cross-references

Sequence databases
EMBL GenBank DDBJ	EU216066 mRNA. Translation: ABX82708.1.
3D structure databases
ProteinModelPortal	A9UF02.
SMR	A9UF02. Positions 1-67, 560-1025, 1538-1644.
ModBase	Search...
Proteomic databases
PRIDE	A9UF02.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG004162.
Enzyme and pathway databases
SignaLink	A9UF02.
Family and domain databases
Gene3D	3.30.505.10. 1 hit. 4.10.280.30. 1 hit.
InterPro	IPR015123. Bcr-Abl_oncoprot_oligo. IPR015015. F-actin_binding. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR001245. Ser-Thr/Tyr_kinase_cat_dom. IPR000980. SH2. IPR001452. SH3_domain. IPR008266. Tyr_kinase_AS. IPR020635. Tyr_kinase_cat_dom. [Graphical view]
Pfam	PF09036. Bcr-Abl_Oligo. 1 hit. PF08919. F_actin_bind. 1 hit. PF07714. Pkinase_Tyr. 1 hit. PF00017. SH2. 1 hit. PF00018. SH3_1. 1 hit. [Graphical view]
PRINTS	PR00401. SH2DOMAIN. PR00109. TYRKINASE.
SMART	SM00808. FABD. 1 hit. SM00252. SH2. 1 hit. SM00326. SH3. 1 hit. SM00219. TyrKc. 1 hit. [Graphical view]
SUPFAM	SSF69036. Bcr-Abl_oncoprot_oligo. 1 hit. SSF56112. Kinase_like. 1 hit. SSF50044. SH3. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. 1 hit. PS50001. SH2. 1 hit. PS50002. SH3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	35465306.

Entry information

Entry name

A9UF02_HUMAN

Accession

Primary (citable) accession number: A9UF02

Entry history

Integrated into UniProtKB/TrEMBL:	February 5, 2008
Last sequence update:	February 5, 2008
Last modified:	May 29, 2013
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.