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Protein
Submitted name:

BCR/ABL fusion protein isoform X9

Gene

BCR/ABL fusion

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.SAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase, Tyrosine-protein kinaseSAAS annotation
LigandATP-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiA9UF02.

Names & Taxonomyi

Protein namesi
Submitted name:
BCR/ABL fusion protein isoform X9Imported
Gene namesi
Name:BCR/ABL fusionImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Pathology & Biotechi

Chemistry databases

DrugBankiDB00619. Imatinib.

PTM / Processingi

Proteomic databases

PaxDbiA9UF02.
PeptideAtlasiA9UF02.
PRIDEiA9UF02.

PTM databases

iPTMnetiA9UF02.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000361423.

Structurei

3D structure databases

ProteinModelPortaliA9UF02.
SMRiA9UF02.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini575 – 635SH3InterPro annotationAdd BLAST61
Domaini641 – 731SH2InterPro annotationAdd BLAST91
Domaini756 – 1007Protein kinaseInterPro annotationAdd BLAST252

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili28 – 55Sequence analysisAdd BLAST28

Keywords - Domaini

Coiled coilSequence analysis, SH3 domainSAAS annotation

Phylogenomic databases

eggNOGiKOG0197. Eukaryota.
COG0515. LUCA.
HOVERGENiHBG004162.

Family and domain databases

Gene3Di1.20.900.10. 1 hit.
3.30.505.10. 1 hit.
4.10.280.30. 1 hit.
InterProiView protein in InterPro
IPR015123. Bcr-Abl_oncoprot_oligo.
IPR000219. DH-domain.
IPR015015. F-actin_binding.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
PfamiView protein in Pfam
PF09036. Bcr-Abl_Oligo. 1 hit.
PF08919. F_actin_bind. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
PRINTSiPR00401. SH2DOMAIN.
PR00109. TYRKINASE.
SMARTiView protein in SMART
SM00808. FABD. 1 hit.
SM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
SSF69036. SSF69036. 1 hit.
PROSITEiView protein in PROSITE
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.

Sequencei

Sequence statusi: Complete.

A9UF02-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVDPVGFAEA WKAQFPDSEP PRMELRSVGD IEQELERCKA SIRRLEQEVN
60 70 80 90 100
QERFRMIYLQ TLLAKEKKSY DRQRWGFRRA AQAPDGASEP RASASRPQPA
110 120 130 140 150
PADGADPPPA EEPEARPDGE GSPGKARPGT ARRPGAAASG ERDDRGPPAS
160 170 180 190 200
VAALRSNFER IRKGHGQPGA DAEKPFYVNV EFHHERGLVK VNDKEVSDRI
210 220 230 240 250
SSLGSQAMQM ERKKSQHGAG SSVGDASRPP YRGRSSESSC GVDGDYEDAE
260 270 280 290 300
LNPRFLKDNL IDANGGSRPP WPPLEYQPYQ SIYVGGMMEG EGKGPLLRSQ
310 320 330 340 350
STSEQEKRLT WPRRSYSPRS FEDCGGGYTP DCSSNENLTS SEEDFSSGQS
360 370 380 390 400
SRVSPSPTTY RMFRDKSRSP SQNSQQSFDS SSPPTPQCHK RHRHCPVVVS
410 420 430 440 450
EATIVGVRKT GQIWPNDGEG AFHGDADGSF GTPPGYGCAA DRAEEQRRHQ
460 470 480 490 500
DGLPYIDDSP SSSPHLSSKG RGSRDALVSG ALESTKASEL DLEKGLEMRK
510 520 530 540 550
WVLSGILASE ETYLSHLQML TNSCVKLQTV HSIPLTINKE EALQRPVASD
560 570 580 590 600
FEPQGLSEAA RWNSKENLLA GPSENDPNLF VALYDFVASG DNTLSITKGE
610 620 630 640 650
KLRVLGYNHN GEWCEAQTKN GQGWVPSNYI TPVNSLEKHS WYHGPVSRNA
660 670 680 690 700
AEYLLSSGIN GSFLVRESES SPGQRSISLR YEGRVYHYRI NTASDGKLYV
710 720 730 740 750
SSESRFNTLA ELVHHHSTVA DGLITTLHYP APKRNKPTVY GVSPNYDKWE
760 770 780 790 800
MERTDITMKH KLGGGQYGEV YEGVWKKYSL TVAVKTLKED TMEVEEFLKE
810 820 830 840 850
AAVMKEIKHP NLVQLLGVCT REPPFYIITE FMTYGNLLDY LRECNRQEVN
860 870 880 890 900
AVVLLYMATQ ISSAMEYLEK KNFIHRDLAA RNCLVGENHL VKVADFGLSR
910 920 930 940 950
LMTGDTYTAH AGAKFPIKWT APESLAYNKF SIKSDVWAFG VLLWEIATYG
960 970 980 990 1000
MSPYPGIDLS QVYELLEKDY RMERPEGCPE KVYELMRACW QWNPSDRPSF
1010 1020 1030 1040 1050
AEIHQAFETM FQESSISDEV EKELGKQGVR GAVSTLLQAP ELPTKTRTSR
1060 1070 1080 1090 1100
RAAEHRDTTD VPEMPHSKGQ GESDPLDHEP AVSPLLPRKE RGPPEGGLNE
1110 1120 1130 1140 1150
DERLLPKDKK TNLFSALIKK KKKTAPTPPK RSSSFREMDG QPERRGAGEE
1160 1170 1180 1190 1200
EGRDISNGAL AFTPLDTADP AKSPKPSNGA GVPNGALRES GGSGFRSPHL
1210 1220 1230 1240 1250
WKKSSTLTSS RLATGEEEGG GSSSKRFLRS CSASCVPHGA KDTEWRSVTL
1260 1270 1280 1290 1300
PRDLQSTGRQ FDSSTFGGHK SEKPALPRKR AGENRSDQVT RGTVTPPPRL
1310 1320 1330 1340 1350
VKKNEEAADE VFKDIMESSP GSSPPNLTPK PLRRQVTVAP ASGLPHKEEA
1360 1370 1380 1390 1400
GKGSALGTPA AAEPVTPTSK AGSGAPGGTS KGPAEESRVR RHKHSSESPG
1410 1420 1430 1440 1450
RDKGKLSRLK PAPPPPPAAS AGKAGGKPSQ SPSQEAAGEA VLGAKTKATS
1460 1470 1480 1490 1500
LVDAVNSDAA KPSQPGEGLK KPVLPATPKP QSAKPSGTPI SPAPVPSTLP
1510 1520 1530 1540 1550
SASSALAGDQ PSSTAFIPLI STRVSLRKTR QPPERIASGA ITKGVVLDST
1560 1570 1580 1590 1600
EALCLAISRN SEQMASHSAV LEAGKNLYTF CVSYVDSIQQ MRNKFAFREA
1610 1620 1630 1640
INKLENNLRE LQICPATAGS GPAATQDFSK LLSSVKEISD IVQR
Length:1,644
Mass (Da):179,323
Last modified:February 5, 2008 - v1
Checksum:iEAF7473B10174EB4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU216066 mRNA. Translation: ABX82708.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU216066 mRNA. Translation: ABX82708.1.

3D structure databases

ProteinModelPortaliA9UF02.
SMRiA9UF02.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000361423.

Chemistry databases

DrugBankiDB00619. Imatinib.

PTM databases

iPTMnetiA9UF02.

Proteomic databases

PaxDbiA9UF02.
PeptideAtlasiA9UF02.
PRIDEiA9UF02.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG0197. Eukaryota.
COG0515. LUCA.
HOVERGENiHBG004162.

Enzyme and pathway databases

SignaLinkiA9UF02.

Miscellaneous databases

ChiTaRSiABL1. human.

Family and domain databases

Gene3Di1.20.900.10. 1 hit.
3.30.505.10. 1 hit.
4.10.280.30. 1 hit.
InterProiView protein in InterPro
IPR015123. Bcr-Abl_oncoprot_oligo.
IPR000219. DH-domain.
IPR015015. F-actin_binding.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
PfamiView protein in Pfam
PF09036. Bcr-Abl_Oligo. 1 hit.
PF08919. F_actin_bind. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
PRINTSiPR00401. SH2DOMAIN.
PR00109. TYRKINASE.
SMARTiView protein in SMART
SM00808. FABD. 1 hit.
SM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
SSF69036. SSF69036. 1 hit.
PROSITEiView protein in PROSITE
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiA9UF02_HUMAN
AccessioniPrimary (citable) accession number: A9UF02
Entry historyiIntegrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: April 12, 2017
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.