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Protein

DNA ligase

Gene

PHYPADRAFT_221958

Organism
Physcomitrella patens subsp. patens (Moss)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotation

Keywords - Biological processi

DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
ORF Names:PHYPADRAFT_221958Imported
OrganismiPhyscomitrella patens subsp. patens (Moss)Imported
Taxonomic identifieri3218 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaBryophytaBryophytinaBryopsidaFunariidaeFunarialesFunariaceaePhyscomitrella
ProteomesiUP000006727 Componenti: Partially assembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi3218.PP1S223_54V6.1.

Structurei

3D structure databases

ProteinModelPortaliA9TG22.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

InParanoidiA9TG22.
KOiK10747.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
InterProiIPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9TG22-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEKKVVAST AAEAVVLLTK KETDFDPEAA AFWKPGQPVP FLFLASALDI
60 70 80 90 100
ISDESGRLAM TNILCNVFRT VIATTPKDLL AVVTLSANRI APAHEGVELG
110 120 130 140 150
IGDAAIVRVL TEAYGRKADQ IKAQMKTLGD LGLVAKASRT SQRTMFKSQP
160 170 180 190 200
LTCAKVLDTF REIAKDSGNQ SQDRKRGRMK ALLVAATECE PLYLVRLLQS
210 220 230 240 250
KLRIGLAEKT VLAALAHAAV LSEVPRVPAN QLTARLEEAE EIMKETYSVL
260 270 280 290 300
PIYEKIISAI LEHGIRKLPE VCNFTLGIPV GPMLAKPTTG VSEVLNKFQD
310 320 330 340 350
MEFSCEYKYD GERAQVHYLQ GGTIEIYSRN AEHNTGKFPD IVAAMPRCMK
360 370 380 390 400
TGTETYVLDC EVVAYDREKN KILPFQVLST RARKGVVLSD IKIQVCLFAF
410 420 430 440 450
DLLYLNGRPL LKEQLNVRRE LLYSSFQEIP GEFQFATAKN SNDLEEIQKF
460 470 480 490 500
LEDAINDSCE GLIVKTLSKD ATYEPAKRSN NWLKLKKDYM NTGGGDSLDL
510 520 530 540 550
VPIGAFYGRG KRVGVYGAFL LACYDEDREE FQSICKIGTG FTEAVLEERS
560 570 580 590 600
VTLKNHVIPQ PRSYYRYGET IGVDVWFEDV EVWEVKAADL SISPVHRAAV
610 620 630 640 650
GLVDPNKGIS LRFPRLMRLR EDKTPVEATS AQQVAEMYRA QKINHGHGGD

ADDDDD
Length:656
Mass (Da):72,907
Last modified:February 5, 2008 - v1
Checksum:iC5B853492DD5520E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS545112 Genomic DNA. Translation: EDQ57593.1.
RefSeqiXP_001777550.1. XM_001777498.1.
UniGeneiPpa.12544.

Genome annotation databases

GeneIDi5940783.
KEGGippp:PHYPADRAFT_221958.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS545112 Genomic DNA. Translation: EDQ57593.1.
RefSeqiXP_001777550.1. XM_001777498.1.
UniGeneiPpa.12544.

3D structure databases

ProteinModelPortaliA9TG22.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3218.PP1S223_54V6.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5940783.
KEGGippp:PHYPADRAFT_221958.

Phylogenomic databases

InParanoidiA9TG22.
KOiK10747.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
InterProiIPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The Physcomitrella genome reveals evolutionary insights into the conquest of land by plants."
    Rensing S.A., Lang D., Zimmer A.D., Terry A., Salamov A., Shapiro H., Nishiyama T., Perroud P.-F., Lindquist E.A., Kamisugi Y., Tanahashi T., Sakakibara K., Fujita T., Oishi K., Shin-I T., Kuroki Y., Toyoda A., Suzuki Y.
    , Hashimoto S.-I., Yamaguchi K., Sugano A., Kohara Y., Fujiyama A., Anterola A., Aoki S., Ashton N., Barbazuk W.B., Barker E., Bennetzen J.L., Blankenship R., Cho S.H., Dutcher S.K., Estelle M., Fawcett J.A., Gundlach H., Hanada K., Heyl A., Hicks K.A., Hughes J., Lohr M., Mayer K., Melkozernov A., Murata T., Nelson D.R., Pils B., Prigge M., Reiss B., Renner T., Rombauts S., Rushton P.J., Sanderfoot A., Schween G., Shiu S.-H., Stueber K., Theodoulou F.L., Tu H., Van de Peer Y., Verrier P.J., Waters E., Wood A., Yang L., Cove D., Cuming A.C., Hasebe M., Lucas S., Mishler B.D., Reski R., Grigoriev I.V., Quatrano R.S., Boore J.L.
    Science 319:64-69(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Gransden 2004Imported.

Entry informationi

Entry nameiA9TG22_PHYPA
AccessioniPrimary (citable) accession number: A9TG22
Entry historyi
Integrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: June 24, 2015
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.