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A9SS00 (MTND2_PHYPA) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 2

EC=1.13.11.54
Alternative name(s):
Acireductone dioxygenase (Fe(2+)-requiring) 2
Short name=ARD 2
Short name=Fe-ARD 2
Gene names
ORF Names:PHYPADRAFT_134384
OrganismPhyscomitrella patens subsp. patens (Moss) [Reference proteome]
Taxonomic identifier3218 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaBryophytaBryophytinaBryopsidaFunariidaeFunarialesFunariaceaePhyscomitrella

Protein attributes

Sequence length195 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the formation of formate and 2-keto-4-methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) By similarity. HAMAP-Rule MF_03154

Catalytic activity

1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + O2 = 4-(methylthio)-2-oxobutanoate + formate. HAMAP-Rule MF_03154

Cofactor

Binds 1 iron ion per monomer. Can also use other divalent metal cations By similarity.

Pathway

Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 5/6. HAMAP-Rule MF_03154

Subcellular location

Cytoplasm By similarity. Nucleus By similarity HAMAP-Rule MF_03154.

Sequence similarities

Belongs to the acireductone dioxygenase (ARD) family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Methionine biosynthesis
   Cellular componentCytoplasm
Nucleus
   LigandIron
Metal-binding
   Molecular functionDioxygenase
Oxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processL-methionine salvage from methylthioadenosine

Inferred from electronic annotation. Source: UniProtKB-HAMAP

regulation of cell division

Inferred from electronic annotation. Source: EnsemblPlants/Gramene

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionacireductone dioxygenase [iron(II)-requiring] activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

iron ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 1951951,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 2 HAMAP-Rule MF_03154
PRO_0000414343

Sites

Metal binding941Iron or nickel By similarity
Metal binding961Iron or nickel By similarity
Metal binding1001Iron or nickel By similarity
Metal binding1391Iron or nickel By similarity

Sequences

Sequence LengthMass (Da)Tools
A9SS00 [UniParc].

Last modified February 5, 2008. Version 1.
Checksum: D0AED4C8E9A82C70

FASTA19523,199
        10         20         30         40         50         60 
MQVQRPPLEA WYMNDSEEDQ RLPHHRNPPE YVTLEKLAAL GVIHWVLDAD NHETDPELSI 

        70         80         90        100        110        120 
IRKDRGYNYT DVITVCPEML PSYEAKIKSF YEEHIHMDEE IRYCLDGSGY FDVRDPEDHW 

       130        140        150        160        170        180 
IRIWVRKGDM IVLPAGCYHR FTLDEHNYIM AMRLFVGEPI WTPYNRPQDE HPVRKGYVHQ 

       190 
FLQPELLDVD MSISA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DS545000 Genomic DNA. Translation: EDQ66042.1.
RefSeqXP_001769170.1. XM_001769118.1.

3D structure databases

ProteinModelPortalA9SS00.
SMRA9SS00. Positions 8-178.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING3218.JGI134384.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5932378.
KEGGppp:PHYPADRAFT_134384.

Phylogenomic databases

KOK08967.
ProtClustDBCLSN2683301.

Enzyme and pathway databases

UniPathwayUPA00904; UER00878.

Family and domain databases

Gene3D2.60.120.10. 1 hit.
HAMAPMF_03154. Salvage_MtnD_euk.
InterProIPR004313. Acireductn_dOase_family.
IPR027496. MTCBP-1_eukaryotes.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERPTHR23418. PTHR23418. 1 hit.
PfamPF03079. ARD. 1 hit.
[Graphical view]
SUPFAMSSF51182. SSF51182. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMTND2_PHYPA
AccessionPrimary (citable) accession number: A9SS00
Entry history
Integrated into UniProtKB/Swiss-Prot: December 14, 2011
Last sequence update: February 5, 2008
Last modified: March 19, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways