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Protein

Adenylosuccinate lyase

Gene

PHYPADRAFT_212225

Organism
Physcomitrella patens subsp. patens (Moss)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate = fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
N(6)-(1,2-dicarboxyethyl)AMP = fumarate + AMP.UniRule annotation

Pathwayi: AMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes AMP from IMP.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Adenylosuccinate synthetase 2, chloroplastic (PURA2), Adenylosuccinate synthetase 1, chloroplastic (PURA1)
  2. Adenylosuccinate lyase (PHYPADRAFT_212225)
This subpathway is part of the pathway AMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes AMP from IMP, the pathway AMP biosynthesis via de novo pathway and in Purine metabolism.

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Adenylosuccinate lyase (PHYPADRAFT_212225)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotation

Keywords - Biological processi

Purine biosynthesisUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00074; UER00132.
UPA00075; UER00336.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylosuccinate lyaseUniRule annotation (EC:4.3.2.2UniRule annotation)
Short name:
ASLUniRule annotation
Alternative name(s):
AdenylosuccinaseUniRule annotation
Gene namesi
ORF Names:PHYPADRAFT_212225Imported
OrganismiPhyscomitrella patens subsp. patens (Moss)Imported
Taxonomic identifieri3218 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaBryophytaBryophytinaBryopsidaFunariidaeFunarialesFunariaceaePhyscomitrella
Proteomesi
  • UP000006727 Componenti: Partially assembled WGS sequence

Interactioni

Protein-protein interaction databases

STRINGi3218.PP1S78_3V6.1.

Structurei

3D structure databases

ProteinModelPortaliA9SGZ0.
SMRiA9SGZ0. Positions 93-543.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini106 – 404299Lyase_1InterPro annotationAdd
BLAST
Domaini423 – 537115ASL_CInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG2700. Eukaryota.
COG0015. LUCA.
InParanoidiA9SGZ0.
KOiK01756.
OMAiTQVNPCD.

Family and domain databases

Gene3Di1.10.275.10. 1 hit.
InterProiIPR024083. Fumarase/histidase_N.
IPR020557. Fumarate_lyase_CS.
IPR000362. Fumarate_lyase_fam.
IPR022761. Fumarate_lyase_N.
IPR008948. L-Aspartase-like.
IPR004769. Pur_lyase.
IPR013539. PurB_C.
[Graphical view]
PANTHERiPTHR11444. PTHR11444. 1 hit.
PfamiPF08328. ASL_C. 1 hit.
PF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSiPR00149. FUMRATELYASE.
SUPFAMiSSF48557. SSF48557. 1 hit.
TIGRFAMsiTIGR00928. purB. 1 hit.
PROSITEiPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9SGZ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNATLSSAVG SVGVAPRQLV ALKSECKSSV HAARAVPSTK RSLASPSISA
60 70 80 90 100
SFSPAPARVE GTPHMRNAVA NHDLHTPVVA DIDLGYLEVD RDLELTELTA
110 120 130 140 150
ISPLDGRYGS KLKPLRAIFS EFGLIRYRVL VEVRWLQMLS NNSGIEEVPR
160 170 180 190 200
FSDKANSLLE DTLANFRVAD ALLVKKVERT TNHDVKAIEY VLKDKIRSDA
210 220 230 240 250
ELSKVLEFVH FACTSEDINN LSHALMLRSA MDSVVLPTMK STVEAIRSLA
260 270 280 290 300
HEFADIPMLS RTHGQPASPT TLGKEMANFC YRLERQIDQV AAVPYFGKIA
310 320 330 340 350
GAVGNYNAHM VAYPNVDWED VAKSFVTSLG LTFNPYTTQI EPHDYIAELY
360 370 380 390 400
DAVIRFNNIL LGFDRDVWSY ISLGYFKQRV IAGEVGSSTM PHKVNPIDFE
410 420 430 440 450
NSEGNLGLAN AAMAHLSSKL PISRWQRDLT DSTVLRNLGV GLGHSVLAYE
460 470 480 490 500
STLKGIRKLQ VNEARIQEDL AECWEVLAEP IQTVMRRYAV EEPYEKLKAV
510 520 530 540
TRDRKVSKEV LHQLIEGLEI PHEAKKSLLE LTPETYIGAA KTLARNI
Length:547
Mass (Da):60,666
Last modified:February 5, 2008 - v1
Checksum:iD9EE9E582D51AA73
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS544967 Genomic DNA. Translation: EDQ69505.1.
RefSeqiXP_001765666.1. XM_001765614.1.
UniGeneiPpa.3933.

Genome annotation databases

EnsemblPlantsiPP1S78_3V6.1; PP1S78_3V6.1; PP1S78_3V6.
PP1S78_3V6.2; PP1S78_3V6.2; PP1S78_3V6.
GeneIDi5928867.
GrameneiPP1S78_3V6.1; PP1S78_3V6.1; PP1S78_3V6.
PP1S78_3V6.2; PP1S78_3V6.2; PP1S78_3V6.
KEGGippp:PHYPADRAFT_212225.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS544967 Genomic DNA. Translation: EDQ69505.1.
RefSeqiXP_001765666.1. XM_001765614.1.
UniGeneiPpa.3933.

3D structure databases

ProteinModelPortaliA9SGZ0.
SMRiA9SGZ0. Positions 93-543.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3218.PP1S78_3V6.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiPP1S78_3V6.1; PP1S78_3V6.1; PP1S78_3V6.
PP1S78_3V6.2; PP1S78_3V6.2; PP1S78_3V6.
GeneIDi5928867.
GrameneiPP1S78_3V6.1; PP1S78_3V6.1; PP1S78_3V6.
PP1S78_3V6.2; PP1S78_3V6.2; PP1S78_3V6.
KEGGippp:PHYPADRAFT_212225.

Phylogenomic databases

eggNOGiKOG2700. Eukaryota.
COG0015. LUCA.
InParanoidiA9SGZ0.
KOiK01756.
OMAiTQVNPCD.

Enzyme and pathway databases

UniPathwayiUPA00074; UER00132.
UPA00075; UER00336.

Family and domain databases

Gene3Di1.10.275.10. 1 hit.
InterProiIPR024083. Fumarase/histidase_N.
IPR020557. Fumarate_lyase_CS.
IPR000362. Fumarate_lyase_fam.
IPR022761. Fumarate_lyase_N.
IPR008948. L-Aspartase-like.
IPR004769. Pur_lyase.
IPR013539. PurB_C.
[Graphical view]
PANTHERiPTHR11444. PTHR11444. 1 hit.
PfamiPF08328. ASL_C. 1 hit.
PF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSiPR00149. FUMRATELYASE.
SUPFAMiSSF48557. SSF48557. 1 hit.
TIGRFAMsiTIGR00928. purB. 1 hit.
PROSITEiPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiA9SGZ0_PHYPA
AccessioniPrimary (citable) accession number: A9SGZ0
Entry historyi
Integrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: September 7, 2016
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.