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A9RAG9 (COX3_DEBHA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 3

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide III
Cytochrome oxidase subunit 3
Gene names
Name:COX3
Encoded onMitochondrion
OrganismDebaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii) [Complete proteome]
Taxonomic identifier284592 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeDebaryomyces

Protein attributes

Sequence length269 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Subunits I, II and III form the functional core of the enzyme complex.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 3 family.

Ontologies

Keywords
   Cellular componentMembrane
Mitochondrion
Mitochondrion inner membrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processaerobic electron transport chain

Inferred from electronic annotation. Source: InterPro

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

mitochondrial inner membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncytochrome-c oxidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 269269Cytochrome c oxidase subunit 3
PRO_0000355033

Regions

Transmembrane21 – 4121Helical; Potential
Transmembrane49 – 6921Helical; Potential
Transmembrane90 – 11021Helical; Potential
Transmembrane132 – 15221Helical; Potential
Transmembrane167 – 18721Helical; Potential
Transmembrane205 – 22521Helical; Potential
Transmembrane247 – 26721Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
A9RAG9 [UniParc].

Last modified February 5, 2008. Version 1.
Checksum: 64AD20631D0375BA

FASTA26930,521
        10         20         30         40         50         60 
MTNNTRGYIQ LHPFHLVGPS PWPMFTSFSL MNLALSLGLT AHGYMNNNMF MLLSTMTVLY 

        70         80         90        100        110        120 
SMTLWFKDIM AESTYLGDHT VAVKRGLMQG FLMFVVSEML MFSSLFWAFL HSALNPTVEM 

       130        140        150        160        170        180 
GMSWPPAGME AISAAELPLL NTMILLASGV TMTYAHHALM NGNRQNTLYG FAYSTLLMVL 

       190        200        210        220        230        240 
FVMFQGLEYT YAGFTITDGV YGSTFFALTG LHGLHMMMLI MMLAMCTMRV YNYDFTNTSH 

       250        260 
VGAETTILYL HVLDVMWLFM YMIVYWWGA 

« Hide

References

[1]"Promiscuous DNA in the nuclear genomes of hemiascomycetous yeasts."
Sacerdot C., Casaregola S., Lafontaine I., Tekaia F., Dujon B., Ozier-Kalogeropoulos O.
FEMS Yeast Res. 8:846-857(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ508940 Genomic DNA. Translation: ABF58070.1.
RefSeqYP_001621421.1. NC_010166.1.

3D structure databases

ProteinModelPortalA9RAG9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING4959.A9RAG9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5845855.
KEGGdha:cox3.

Phylogenomic databases

eggNOGCOG1845.
KOK02262.
OrthoDBEOG7V76HP.

Family and domain databases

Gene3D1.20.120.80. 1 hit.
InterProIPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR000298. Cyt_c_oxidase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
[Graphical view]
PANTHERPTHR11403. PTHR11403. 1 hit.
PfamPF00510. COX3. 1 hit.
[Graphical view]
SUPFAMSSF81452. SSF81452. 1 hit.
PROSITEPS50253. COX3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX3_DEBHA
AccessionPrimary (citable) accession number: A9RAG9
Entry history
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: February 5, 2008
Last modified: April 16, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families