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A9RAG1

- COX2_DEBHA

UniProt

A9RAG1 - COX2_DEBHA

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Protein

Cytochrome c oxidase subunit 2

Gene
COX2
Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1 By similarity.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Copper A By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi175 – 1751Copper A By similarity
Metal bindingi210 – 2101Copper A By similarity
Metal bindingi214 – 2141Copper A By similarity
Metal bindingi218 – 2181Copper A By similarity

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:COX2
Encoded oniMitochondrion
OrganismiDebaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Taxonomic identifieri284592 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeDebaryomyces
ProteomesiUP000000599: Mitochondrion

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei31 – 5121Helical; Reviewed predictionAdd
BLAST
Transmembranei72 – 9221Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 246246Cytochrome c oxidase subunit 2PRO_0000355032Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliA9RAG1.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1622.
KOiK02261.
OrthoDBiEOG7WDNDC.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9RAG1-1 [UniParc]FASTAAdd to Basket

« Hide

MIWTDVPTPW GMRFQDAATP NAEGMHELYD HMMYYLALML GLVSYMLYVM    50
MKDYKNNTFA YKYIKHGQTL EIMWTMFPAV MLLLMAFPSF MLLYLCDEVL 100
TPAMTVKVVG LQWYWKYEYS DFVSETGETV EYESYVMPED MLEEGQLRLL 150
DTDTSMVVPV DTHVRFMVTA NDVLHCFTMP SLGIKVDACP GRLNQVSALM 200
QRTGVYYGQC SELCGVNHGL MPIKTECVPI GDFVEWLGEQ ENVYVA 246
Length:246
Mass (Da):28,359
Last modified:February 5, 2008 - v1
Checksum:i8F8982C0B23935B4
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti39 – 391M → V in strain: CBS 789 and CLIB 381. 2 Publications
Natural varianti46 – 461M → L in strain: CLIB 660. 1 Publication
Natural varianti51 – 511M → I in strain: CBS 789 and CLIB 381. 2 Publications
Natural varianti106 – 1061V → I in strain: CBS 789 and CLIB 381. 2 Publications
Natural varianti179 – 1791M → I in strain: CBS 789 and CLIB 381. 2 Publications

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti223 – 2231I → T in ABU80664. 1 Publication
Sequence conflicti223 – 2231I → T in ABU80663. 1 Publication
Sequence conflicti223 – 2231I → T in CAQ51421. 1 Publication
Sequence conflicti223 – 2231I → T in CAQ51422. 1 Publication
Sequence conflicti223 – 2231I → T in CAQ51423. 1 Publication
Sequence conflicti223 – 2231I → T in CAQ51424. 1 Publication
Sequence conflicti223 – 2231I → T in CAQ51428. 1 Publication
Sequence conflicti223 – 2231I → T in CAQ51429. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ508940 Genomic DNA. Translation: ABF58062.1.
EF599377 Genomic DNA. Translation: ABU80663.1.
EF599378 Genomic DNA. Translation: ABU80664.1.
AM991984 Genomic DNA. Translation: CAQ51421.1.
AM991986 Genomic DNA. Translation: CAQ51423.1.
AM991987 Genomic DNA. Translation: CAQ51424.1.
AM991985 Genomic DNA. Translation: CAQ51422.1.
AM991991 Genomic DNA. Translation: CAQ51428.1.
AM991992 Genomic DNA. Translation: CAQ51429.1.
D55727 Genomic DNA. Translation: BAA09541.1.
RefSeqiYP_001621413.1. NC_010166.1.

Genome annotation databases

GeneIDi5845854.
KEGGidha:cox2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ508940 Genomic DNA. Translation: ABF58062.1 .
EF599377 Genomic DNA. Translation: ABU80663.1 .
EF599378 Genomic DNA. Translation: ABU80664.1 .
AM991984 Genomic DNA. Translation: CAQ51421.1 .
AM991986 Genomic DNA. Translation: CAQ51423.1 .
AM991987 Genomic DNA. Translation: CAQ51424.1 .
AM991985 Genomic DNA. Translation: CAQ51422.1 .
AM991991 Genomic DNA. Translation: CAQ51428.1 .
AM991992 Genomic DNA. Translation: CAQ51429.1 .
D55727 Genomic DNA. Translation: BAA09541.1 .
RefSeqi YP_001621413.1. NC_010166.1.

3D structure databases

ProteinModelPortali A9RAG1.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 5845854.
KEGGi dha:cox2.

Phylogenomic databases

eggNOGi COG1622.
KOi K02261.
OrthoDBi EOG7WDNDC.

Family and domain databases

Gene3Di 1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProi IPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view ]
Pfami PF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsi TIGR02866. CoxB. 1 hit.
PROSITEi PS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968.
  2. "Re-examining the phylogeny of clinically relevant Candida species and allied genera based on multigene analyses."
    Tsui C.K.M., Daniel H.-M., Robert V., Meyer W.
    FEMS Yeast Res. 8:651-659(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 29-246, VARIANTS VAL-39; ILE-51; ILE-106 AND ILE-179.
    Strain: ATCC 20278 / CBS 789 / IFO 0015 / JCM 2104 / WM 66 and ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968.
  3. "Differentiation of Candida famata and Debaryomyces hansenii by rDNA intergenic spacer fingerprinting and revaluation of phylogenetic relationships between D.hansenii, C.famata, D.fabryi and C.flareri. Description of D.vietnamensis sp. nov."
    Nguyen H.V., Gaillardin C., Neuveglise C.
    Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 29-223, VARIANTS VAL-39; LEU-46; ILE-51; ILE-106 AND ILE-179.
    Strain: ATCC 20278 / CBS 789 / IFO 0015 / JCM 2104 / WM 66, CBS 1961, CBS 766, CLIB 381, CLIB 660 and Kam473.
  4. "Amplification and sequencing of cytochrome c oxidase subunit II gene for phylogenetic analysis of yeast mitochondria."
    Nakagawa Y.
    Submitted (JUN-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-189.
    Strain: ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968.

Entry informationi

Entry nameiCOX2_DEBHA
AccessioniPrimary (citable) accession number: A9RAG1
Secondary accession number(s): B0LCE8
, B0LCE9, B4F4K1, B4F4K2, B4F4K4, B4F4K8, Q34322
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: February 5, 2008
Last modified: April 16, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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