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A9RAG1 (COX2_DEBHA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 2

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene names
Name:COX2
Encoded onMitochondrion
OrganismDebaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii) [Complete proteome]
Taxonomic identifier284592 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeDebaryomyces

Protein attributes

Sequence length246 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1 By similarity.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactor

Copper A By similarity.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 246246Cytochrome c oxidase subunit 2
PRO_0000355032

Regions

Transmembrane31 – 5121Helical; Potential
Transmembrane72 – 9221Helical; Potential

Sites

Metal binding1751Copper A By similarity
Metal binding2101Copper A By similarity
Metal binding2141Copper A By similarity
Metal binding2181Copper A By similarity

Natural variations

Natural variant391M → V in strain: CBS 789 and CLIB 381. Ref.2 Ref.3
Natural variant461M → L in strain: CLIB 660. Ref.3
Natural variant511M → I in strain: CBS 789 and CLIB 381. Ref.2 Ref.3
Natural variant1061V → I in strain: CBS 789 and CLIB 381. Ref.2 Ref.3
Natural variant1791M → I in strain: CBS 789 and CLIB 381. Ref.2 Ref.3

Experimental info

Sequence conflict2231I → T in ABU80664. Ref.2
Sequence conflict2231I → T in ABU80663. Ref.2
Sequence conflict2231I → T in CAQ51421. Ref.3
Sequence conflict2231I → T in CAQ51422. Ref.3
Sequence conflict2231I → T in CAQ51423. Ref.3
Sequence conflict2231I → T in CAQ51424. Ref.3
Sequence conflict2231I → T in CAQ51428. Ref.3
Sequence conflict2231I → T in CAQ51429. Ref.3

Sequences

Sequence LengthMass (Da)Tools
A9RAG1 [UniParc].

Last modified February 5, 2008. Version 1.
Checksum: 8F8982C0B23935B4

FASTA24628,359
        10         20         30         40         50         60 
MIWTDVPTPW GMRFQDAATP NAEGMHELYD HMMYYLALML GLVSYMLYVM MKDYKNNTFA 

        70         80         90        100        110        120 
YKYIKHGQTL EIMWTMFPAV MLLLMAFPSF MLLYLCDEVL TPAMTVKVVG LQWYWKYEYS 

       130        140        150        160        170        180 
DFVSETGETV EYESYVMPED MLEEGQLRLL DTDTSMVVPV DTHVRFMVTA NDVLHCFTMP 

       190        200        210        220        230        240 
SLGIKVDACP GRLNQVSALM QRTGVYYGQC SELCGVNHGL MPIKTECVPI GDFVEWLGEQ 


ENVYVA 

« Hide

References

« Hide 'large scale' references
[1]"Promiscuous DNA in the nuclear genomes of hemiascomycetous yeasts."
Sacerdot C., Casaregola S., Lafontaine I., Tekaia F., Dujon B., Ozier-Kalogeropoulos O.
FEMS Yeast Res. 8:846-857(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968.
[2]"Re-examining the phylogeny of clinically relevant Candida species and allied genera based on multigene analyses."
Tsui C.K.M., Daniel H.-M., Robert V., Meyer W.
FEMS Yeast Res. 8:651-659(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 29-246, VARIANTS VAL-39; ILE-51; ILE-106 AND ILE-179.
Strain: ATCC 20278 / CBS 789 / IFO 0015 / JCM 2104 / WM 66 and ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968.
[3]"Differentiation of Candida famata and Debaryomyces hansenii by rDNA intergenic spacer fingerprinting and revaluation of phylogenetic relationships between D.hansenii, C.famata, D.fabryi and C.flareri. Description of D.vietnamensis sp. nov."
Nguyen H.V., Gaillardin C., Neuveglise C.
Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 29-223, VARIANTS VAL-39; LEU-46; ILE-51; ILE-106 AND ILE-179.
Strain: ATCC 20278 / CBS 789 / IFO 0015 / JCM 2104 / WM 66, CBS 1961, CBS 766, CLIB 381, CLIB 660 and Kam473.
[4]"Amplification and sequencing of cytochrome c oxidase subunit II gene for phylogenetic analysis of yeast mitochondria."
Nakagawa Y.
Submitted (JUN-1995) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-189.
Strain: ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ508940 Genomic DNA. Translation: ABF58062.1.
EF599377 Genomic DNA. Translation: ABU80663.1.
EF599378 Genomic DNA. Translation: ABU80664.1.
AM991984 Genomic DNA. Translation: CAQ51421.1.
AM991986 Genomic DNA. Translation: CAQ51423.1.
AM991987 Genomic DNA. Translation: CAQ51424.1.
AM991985 Genomic DNA. Translation: CAQ51422.1.
AM991991 Genomic DNA. Translation: CAQ51428.1.
AM991992 Genomic DNA. Translation: CAQ51429.1.
D55727 Genomic DNA. Translation: BAA09541.1.
RefSeqYP_001621413.1. NC_010166.1.

3D structure databases

ProteinModelPortalA9RAG1.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5845854.
KEGGdha:cox2.

Phylogenomic databases

eggNOGCOG1622.
KOK02261.
OrthoDBEOG7WDNDC.

Family and domain databases

Gene3D1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsTIGR02866. CoxB. 1 hit.
PROSITEPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX2_DEBHA
AccessionPrimary (citable) accession number: A9RAG1
Secondary accession number(s): B0LCE8 expand/collapse secondary AC list , B0LCE9, B4F4K1, B4F4K2, B4F4K4, B4F4K8, Q34322
Entry history
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: February 5, 2008
Last modified: April 16, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families