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A9RAG1

- COX2_DEBHA

UniProt

A9RAG1 - COX2_DEBHA

Protein

Cytochrome c oxidase subunit 2

Gene

COX2

Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (05 Feb 2008)
      Previous versions | rss
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    Functioni

    Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1 By similarity.By similarity

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    Cofactori

    Copper A.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi175 – 1751Copper ABy similarity
    Metal bindingi210 – 2101Copper ABy similarity
    Metal bindingi214 – 2141Copper ABy similarity
    Metal bindingi218 – 2181Copper ABy similarity

    GO - Molecular functioni

    1. copper ion binding Source: InterPro
    2. cytochrome-c oxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. electron transport chain Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Copper, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome c oxidase polypeptide II
    Gene namesi
    Name:COX2
    Encoded oniMitochondrion
    OrganismiDebaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
    Taxonomic identifieri284592 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeDebaryomyces
    ProteomesiUP000000599: Mitochondrion

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell
    3. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 246246Cytochrome c oxidase subunit 2PRO_0000355032Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliA9RAG1.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei31 – 5121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei72 – 9221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1622.
    KOiK02261.
    OrthoDBiEOG7WDNDC.

    Family and domain databases

    Gene3Di1.10.287.90. 1 hit.
    2.60.40.420. 1 hit.
    InterProiIPR001505. Copper_CuA.
    IPR008972. Cupredoxin.
    IPR014222. Cyt_c_oxidase_su2.
    IPR002429. Cyt_c_oxidase_su2_C.
    IPR011759. Cyt_c_oxidase_su2_TM_dom.
    [Graphical view]
    PfamiPF00116. COX2. 1 hit.
    PF02790. COX2_TM. 1 hit.
    [Graphical view]
    SUPFAMiSSF49503. SSF49503. 1 hit.
    SSF81464. SSF81464. 1 hit.
    TIGRFAMsiTIGR02866. CoxB. 1 hit.
    PROSITEiPS00078. COX2. 1 hit.
    PS50857. COX2_CUA. 1 hit.
    PS50999. COX2_TM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A9RAG1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIWTDVPTPW GMRFQDAATP NAEGMHELYD HMMYYLALML GLVSYMLYVM    50
    MKDYKNNTFA YKYIKHGQTL EIMWTMFPAV MLLLMAFPSF MLLYLCDEVL 100
    TPAMTVKVVG LQWYWKYEYS DFVSETGETV EYESYVMPED MLEEGQLRLL 150
    DTDTSMVVPV DTHVRFMVTA NDVLHCFTMP SLGIKVDACP GRLNQVSALM 200
    QRTGVYYGQC SELCGVNHGL MPIKTECVPI GDFVEWLGEQ ENVYVA 246
    Length:246
    Mass (Da):28,359
    Last modified:February 5, 2008 - v1
    Checksum:i8F8982C0B23935B4
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti223 – 2231I → T in ABU80664. (PubMed:18248416)Curated
    Sequence conflicti223 – 2231I → T in ABU80663. (PubMed:18248416)Curated
    Sequence conflicti223 – 2231I → T in CAQ51421. 1 PublicationCurated
    Sequence conflicti223 – 2231I → T in CAQ51422. 1 PublicationCurated
    Sequence conflicti223 – 2231I → T in CAQ51423. 1 PublicationCurated
    Sequence conflicti223 – 2231I → T in CAQ51424. 1 PublicationCurated
    Sequence conflicti223 – 2231I → T in CAQ51428. 1 PublicationCurated
    Sequence conflicti223 – 2231I → T in CAQ51429. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti39 – 391M → V in strain: CBS 789 and CLIB 381. 2 Publications
    Natural varianti46 – 461M → L in strain: CLIB 660. 1 Publication
    Natural varianti51 – 511M → I in strain: CBS 789 and CLIB 381. 2 Publications
    Natural varianti106 – 1061V → I in strain: CBS 789 and CLIB 381. 2 Publications
    Natural varianti179 – 1791M → I in strain: CBS 789 and CLIB 381. 2 Publications

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ508940 Genomic DNA. Translation: ABF58062.1.
    EF599377 Genomic DNA. Translation: ABU80663.1.
    EF599378 Genomic DNA. Translation: ABU80664.1.
    AM991984 Genomic DNA. Translation: CAQ51421.1.
    AM991986 Genomic DNA. Translation: CAQ51423.1.
    AM991987 Genomic DNA. Translation: CAQ51424.1.
    AM991985 Genomic DNA. Translation: CAQ51422.1.
    AM991991 Genomic DNA. Translation: CAQ51428.1.
    AM991992 Genomic DNA. Translation: CAQ51429.1.
    D55727 Genomic DNA. Translation: BAA09541.1.
    RefSeqiYP_001621413.1. NC_010166.1.

    Genome annotation databases

    GeneIDi5845854.
    KEGGidha:cox2.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ508940 Genomic DNA. Translation: ABF58062.1 .
    EF599377 Genomic DNA. Translation: ABU80663.1 .
    EF599378 Genomic DNA. Translation: ABU80664.1 .
    AM991984 Genomic DNA. Translation: CAQ51421.1 .
    AM991986 Genomic DNA. Translation: CAQ51423.1 .
    AM991987 Genomic DNA. Translation: CAQ51424.1 .
    AM991985 Genomic DNA. Translation: CAQ51422.1 .
    AM991991 Genomic DNA. Translation: CAQ51428.1 .
    AM991992 Genomic DNA. Translation: CAQ51429.1 .
    D55727 Genomic DNA. Translation: BAA09541.1 .
    RefSeqi YP_001621413.1. NC_010166.1.

    3D structure databases

    ProteinModelPortali A9RAG1.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 5845854.
    KEGGi dha:cox2.

    Phylogenomic databases

    eggNOGi COG1622.
    KOi K02261.
    OrthoDBi EOG7WDNDC.

    Family and domain databases

    Gene3Di 1.10.287.90. 1 hit.
    2.60.40.420. 1 hit.
    InterProi IPR001505. Copper_CuA.
    IPR008972. Cupredoxin.
    IPR014222. Cyt_c_oxidase_su2.
    IPR002429. Cyt_c_oxidase_su2_C.
    IPR011759. Cyt_c_oxidase_su2_TM_dom.
    [Graphical view ]
    Pfami PF00116. COX2. 1 hit.
    PF02790. COX2_TM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49503. SSF49503. 1 hit.
    SSF81464. SSF81464. 1 hit.
    TIGRFAMsi TIGR02866. CoxB. 1 hit.
    PROSITEi PS00078. COX2. 1 hit.
    PS50857. COX2_CUA. 1 hit.
    PS50999. COX2_TM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968.
    2. "Re-examining the phylogeny of clinically relevant Candida species and allied genera based on multigene analyses."
      Tsui C.K.M., Daniel H.-M., Robert V., Meyer W.
      FEMS Yeast Res. 8:651-659(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 29-246, VARIANTS VAL-39; ILE-51; ILE-106 AND ILE-179.
      Strain: ATCC 20278 / CBS 789 / IFO 0015 / JCM 2104 / WM 66 and ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968.
    3. "Differentiation of Candida famata and Debaryomyces hansenii by rDNA intergenic spacer fingerprinting and revaluation of phylogenetic relationships between D.hansenii, C.famata, D.fabryi and C.flareri. Description of D.vietnamensis sp. nov."
      Nguyen H.V., Gaillardin C., Neuveglise C.
      Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 29-223, VARIANTS VAL-39; LEU-46; ILE-51; ILE-106 AND ILE-179.
      Strain: ATCC 20278 / CBS 789 / IFO 0015 / JCM 2104 / WM 66, CBS 1961, CBS 766, CLIB 381, CLIB 660 and Kam473.
    4. "Amplification and sequencing of cytochrome c oxidase subunit II gene for phylogenetic analysis of yeast mitochondria."
      Nakagawa Y.
      Submitted (JUN-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-189.
      Strain: ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968.

    Entry informationi

    Entry nameiCOX2_DEBHA
    AccessioniPrimary (citable) accession number: A9RAG1
    Secondary accession number(s): B0LCE8
    , B0LCE9, B4F4K1, B4F4K2, B4F4K4, B4F4K8, Q34322
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 25, 2008
    Last sequence update: February 5, 2008
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3