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Protein

Exodeoxyribonuclease 7 large subunit

Gene

xseA

Organism
Yersinia pestis bv. Antiqua (strain Angola)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.UniRule annotation

Catalytic activityi

Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Exonuclease, Hydrolase, Nuclease

Enzyme and pathway databases

BioCyciYPES349746:GHPB-410-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Exodeoxyribonuclease 7 large subunitUniRule annotation (EC:3.1.11.6UniRule annotation)
Alternative name(s):
Exodeoxyribonuclease VII large subunitUniRule annotation
Short name:
Exonuclease VII large subunitUniRule annotation
Gene namesi
Name:xseAUniRule annotation
Ordered Locus Names:YpAngola_A0410
OrganismiYersinia pestis bv. Antiqua (strain Angola)
Taxonomic identifieri349746 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 459459Exodeoxyribonuclease 7 large subunitPRO_1000122105Add
BLAST

Interactioni

Subunit structurei

Heterooligomer composed of large and small subunits.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the XseA family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000229265.
KOiK03601.
OMAiENAQVRC.
OrthoDBiEOG64R65J.

Family and domain databases

HAMAPiMF_00378. Exonuc_7_L.
InterProiIPR003753. Exonuc_VII_L.
IPR020579. Exonuc_VII_lsu_C.
IPR025824. OB-fold_nuc-bd_dom.
[Graphical view]
PfamiPF02601. Exonuc_VII_L. 1 hit.
PF13742. tRNA_anti_2. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00237. xseA. 1 hit.

Sequencei

Sequence statusi: Complete.

A9R7Z4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQSSASSIF TVSRLNQTVR ELLEREMGQI WLTAEISNFS QPASGHWYFT
60 70 80 90 100
LKDDRAQVRC AMFRNSNRRT TFRPQNGQQV LVRASITLYE PRGDYQLIAE
110 120 130 140 150
SMQPAGDGLL QQQFEQLKQQ LAAEGLFDQS HKQPLPHPAK QVGVITSASG
160 170 180 190 200
AALHDVLHVL QRRDPSLPVI IYPTSVQGVD APLQIVRAIQ LANLRAECDV
210 220 230 240 250
LIVGRGGGSL EDLWSFNDER VARAIFNSHI PIVSAVGHET DVTIADFVAD
260 270 280 290 300
LRAPTPSAAA ELVSRNQIEL VRQIQGQQQR MEMAMDYYLA QRNQQFTRLE
310 320 330 340 350
HRLQQQHPHL RLARQQTLLL KLQRRLEESA QTQIRLLSKR TERLQQRLQQ
360 370 380 390 400
VQPQGQIHRY NQRVQQQEYR LRQAVERQLN GYRQRFGIAC SQLEAVSPLA
410 420 430 440 450
TLARGYSVTQ TPAGALLKTT KQVQAGDKLT TRLQDGWVES EITQVTVAKK

SRQKKVVTQ
Length:459
Mass (Da):52,098
Last modified:February 5, 2008 - v1
Checksum:i547EEFFBA10BA6D4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000901 Genomic DNA. Translation: ABX86881.1.
RefSeqiWP_002209810.1. NZ_CP009935.1.

Genome annotation databases

EnsemblBacteriaiABX86881; ABX86881; YpAngola_A0410.
KEGGiypg:YpAngola_A0410.
PATRICi18569760. VBIYerPes97331_0701.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000901 Genomic DNA. Translation: ABX86881.1.
RefSeqiWP_002209810.1. NZ_CP009935.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABX86881; ABX86881; YpAngola_A0410.
KEGGiypg:YpAngola_A0410.
PATRICi18569760. VBIYerPes97331_0701.

Phylogenomic databases

HOGENOMiHOG000229265.
KOiK03601.
OMAiENAQVRC.
OrthoDBiEOG64R65J.

Enzyme and pathway databases

BioCyciYPES349746:GHPB-410-MONOMER.

Family and domain databases

HAMAPiMF_00378. Exonuc_7_L.
InterProiIPR003753. Exonuc_VII_L.
IPR020579. Exonuc_VII_lsu_C.
IPR025824. OB-fold_nuc-bd_dom.
[Graphical view]
PfamiPF02601. Exonuc_VII_L. 1 hit.
PF13742. tRNA_anti_2. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00237. xseA. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the deep-rooted Yersinia pestis strain Angola reveals new insights into the evolution and pangenome of the plague bacterium."
    Eppinger M., Worsham P.L., Nikolich M.P., Riley D.R., Sebastian Y., Mou S., Achtman M., Lindler L.E., Ravel J.
    J. Bacteriol. 192:1685-1699(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Angola.

Entry informationi

Entry nameiEX7L_YERPG
AccessioniPrimary (citable) accession number: A9R7Z4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 5, 2008
Last modified: November 11, 2015
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.