A9R2Q4 (ARGA_YERPG) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Amino-acid acetyltransferase
EC=2.3.1.1

Alternative name(s):
N-acetylglutamate synthase
Short name=AGS
Short name=NAGS

Gene names

Name:	argA
Ordered Locus Names:	YpAngola_A3229

Organism

Yersinia pestis bv. Antiqua (strain Angola) [Complete proteome] [HAMAP]

Taxonomic identifier

349746 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Yersinia

Protein attributes

Sequence length	441 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Acetyl-CoA + L-glutamate = CoA + N-acetyl-L-glutamate. HAMAP MF_01105
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4. HAMAP MF_01105
Subunit structure	Homohexamer By similarity. HAMAP MF_01105
Subcellular location	Cytoplasm By similarity HAMAP MF_01105.
Sequence similarities	Belongs to the acetyltransferase family. ArgA subfamily. Contains 1 N-acetyltransferase domain.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	acetyl-CoA:L-glutamate N-acetyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 441	441	Amino-acid acetyltransferase HAMAP MF_01105		PRO_1000137056
Regions
	Domain	295 – 434	140	N-acetyltransferase

Sequences

	Sequence		Length	Mass (Da)
	A9R2Q4 [UniParc]. Last modified February 5, 2008. Version 1. Checksum: EBDC58CA73BC1960	FASTA	441	49,355
	10 20 30 40 50 60 MKERSTELVQ GFRHSVPYIN AHRGKTFVVM LGGEAIEHEN FSSIVNDIGL LHSLGIRLVV 70 80 90 100 110 120 VYGARPQIDS NLADHNYEPI YHKHTRVTDA RTLEMVKQAA GLLQLDITAR LSMSLNNTPL 130 140 150 160 170 180 QGAHINVVSG NFIIAQPLGV DDGVDYCHSG RIRRIDEEAI HRQLDNGAIV LLGPVAVSVT 190 200 210 220 230 240 GESFNLTSEE VATQLAIKLK AEKMIGFCSS QGVTDSEGNI ISELFPNDAQ KRIEDLEQDG 250 260 270 280 290 300 DYNSGTVRFL RGAVKACRSG VRRSHLLSYQ EDGALIQELF SRDGIGTQIV MESAEQVRRA 310 320 330 340 350 360 TINDIGGILE LIRPLEQQGI LVRRSREQLE MEIDKFTIIE RDNLTIACAA LYPFPDEHIG 370 380 390 400 410 420 EMACVAVHPD YRSSSRGEML LNRITNQARQ MGLKKLFVLT TRSIHWFQER GFTPAEVDVL 430 440 PIQKQELYNY QRRSKILLAD L

References

[1]

"Genome sequence of the deep-rooted Yersinia pestis strain Angola reveals new insights into the evolution and pangenome of the plague bacterium." Eppinger M., Worsham P.L., Nikolich M.P., Riley D.R., Sebastian Y., Mou S., Achtman M., Lindler L.E., Ravel J. J. Bacteriol. 192:1685-1699(2010) [PubMed: 20061468] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Angola.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000901 Genomic DNA. Translation: ABX87556.1.
RefSeq	YP_001607580.1. NC_010159.1.
3D structure databases
ProteinModelPortal	A9R2Q4.
ModBase	Search...
Protein-protein interaction databases
STRING	A9R2Q4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5801705.
GenomeReviews	Gene locus YpAngola_A3229 in contig CP000901_GR.
KEGG	ypg:YpAngola_A3229.
PATRIC	18576052. VBIYerPes97331_3785.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG545264.
OMA	AFNLAME.
ProtClustDB	PRK05279.
Enzyme and pathway databases
BioCyc	YPES349746:YPANGOLA_A3229-MONOMER.
Family and domain databases
HAMAP	MF_01105. N-acetyl_glu_synth. [Tree]
InterPro	IPR000182. AcTrfase_GCN5-related_dom. IPR016181. Acyl_CoA_acyltransferase. IPR001048. Asp/Glu/Uridylate_kinase. IPR010167. NH2A_AcTrfase_ArgA. [Graphical view]
Gene3D	G3DSA:3.40.1160.10. Aa_kinase. 1 hit. G3DSA:3.40.630.30. Acyl_CoA_acyltransferase. 1 hit.
KO	K14682.
Pfam	PF00696. AA_kinase. 1 hit. PF00583. Acetyltransf_1. 1 hit. [Graphical view]
PIRSF	PIRSF000423. ArgA. 1 hit.
SUPFAM	SSF53633. Aa_kinase. 1 hit. SSF55729. Acyl_CoA_acyltransferase. 1 hit.
TIGRFAMs	TIGR01890. N-Ac-Glu-synth. 1 hit.
PROSITE	PS51186. GNAT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGA_YERPG

Accession

Primary (citable) accession number: A9R2Q4

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	February 5, 2008
Last modified:	January 25, 2012
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program