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A9R1B1

- GCH1_YERPG

UniProt

A9R1B1 - GCH1_YERPG

Protein

GTP cyclohydrolase 1

Gene

folE

Organism
Yersinia pestis bv. Antiqua (strain Angola)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (05 Feb 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi109 – 1091ZincUniRule annotation
    Metal bindingi112 – 1121ZincUniRule annotation
    Metal bindingi180 – 1801ZincUniRule annotation

    GO - Molecular functioni

    1. GTP binding Source: UniProtKB-KW
    2. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
    2. one-carbon metabolic process Source: UniProtKB-HAMAP
    3. tetrahydrofolate biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    GTP-binding, Metal-binding, Nucleotide-binding, Zinc

    Enzyme and pathway databases

    BioCyciYPES349746:GHPB-3020-MONOMER.
    UniPathwayiUPA00848; UER00151.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTP cyclohydrolase 1UniRule annotation (EC:3.5.4.16UniRule annotation)
    Alternative name(s):
    GTP cyclohydrolase IUniRule annotation
    Short name:
    GTP-CH-IUniRule annotation
    Gene namesi
    Name:folEUniRule annotation
    Ordered Locus Names:YpAngola_A3014
    OrganismiYersinia pestis bv. Antiqua (strain Angola)
    Taxonomic identifieri349746 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
    ProteomesiUP000001204: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 220220GTP cyclohydrolase 1PRO_1000100213Add
    BLAST

    Proteomic databases

    PRIDEiA9R1B1.

    Interactioni

    Subunit structurei

    Homopolymer.UniRule annotation

    Protein-protein interaction databases

    STRINGi349746.YpAngola_A3014.

    Structurei

    3D structure databases

    ProteinModelPortaliA9R1B1.
    SMRiA9R1B1. Positions 3-219.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GTP cyclohydrolase I family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0302.
    HOGENOMiHOG000221222.
    KOiK01495.
    OMAiVQFFSSR.
    OrthoDBiEOG6XHC8G.

    Family and domain databases

    HAMAPiMF_00223. FolE.
    InterProiIPR001474. GTP_CycHdrlase_I.
    IPR018234. GTP_CycHdrlase_I_CS.
    IPR020602. GTP_CycHdrlase_I_dom.
    [Graphical view]
    PANTHERiPTHR11109. PTHR11109. 1 hit.
    PfamiPF01227. GTP_cyclohydroI. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00063. folE. 1 hit.
    PROSITEiPS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
    PS00860. GTP_CYCLOHYDROL_1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A9R1B1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSLSKEAEL VHQALLARGL ETPLRKPELD AETRKTRIQA HMTEVMHLLN    50
    LDLTDDSLAD TPRRIAKMYV DEIFSGLDYE NFPKITLIQN KMKVDEMVTV 100
    RDITLTSTCE HHFVTIDGKA TVAYIPKDSV IGLSKINRIV QFFAQRPQVQ 150
    ERLTQQILLA LQTLLGTNNV AVSIDAVHYC VKARGIRDAT SATTTTSLGG 200
    LFKSSQNTRQ EFLRAVRHHG 220
    Length:220
    Mass (Da):24,714
    Last modified:February 5, 2008 - v1
    Checksum:i5B497C8B4FA301F8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000901 Genomic DNA. Translation: ABX87571.1.
    RefSeqiYP_001607382.1. NC_010159.1.

    Genome annotation databases

    EnsemblBacteriaiABX87571; ABX87571; YpAngola_A3014.
    GeneIDi5801486.
    KEGGiypg:YpAngola_A3014.
    PATRICi18575567. VBIYerPes97331_3547.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000901 Genomic DNA. Translation: ABX87571.1 .
    RefSeqi YP_001607382.1. NC_010159.1.

    3D structure databases

    ProteinModelPortali A9R1B1.
    SMRi A9R1B1. Positions 3-219.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 349746.YpAngola_A3014.

    Proteomic databases

    PRIDEi A9R1B1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABX87571 ; ABX87571 ; YpAngola_A3014 .
    GeneIDi 5801486.
    KEGGi ypg:YpAngola_A3014.
    PATRICi 18575567. VBIYerPes97331_3547.

    Phylogenomic databases

    eggNOGi COG0302.
    HOGENOMi HOG000221222.
    KOi K01495.
    OMAi VQFFSSR.
    OrthoDBi EOG6XHC8G.

    Enzyme and pathway databases

    UniPathwayi UPA00848 ; UER00151 .
    BioCyci YPES349746:GHPB-3020-MONOMER.

    Family and domain databases

    HAMAPi MF_00223. FolE.
    InterProi IPR001474. GTP_CycHdrlase_I.
    IPR018234. GTP_CycHdrlase_I_CS.
    IPR020602. GTP_CycHdrlase_I_dom.
    [Graphical view ]
    PANTHERi PTHR11109. PTHR11109. 1 hit.
    Pfami PF01227. GTP_cyclohydroI. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00063. folE. 1 hit.
    PROSITEi PS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
    PS00860. GTP_CYCLOHYDROL_1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the deep-rooted Yersinia pestis strain Angola reveals new insights into the evolution and pangenome of the plague bacterium."
      Eppinger M., Worsham P.L., Nikolich M.P., Riley D.R., Sebastian Y., Mou S., Achtman M., Lindler L.E., Ravel J.
      J. Bacteriol. 192:1685-1699(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Angola.

    Entry informationi

    Entry nameiGCH1_YERPG
    AccessioniPrimary (citable) accession number: A9R1B1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: February 5, 2008
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3