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A9R0L2

- A9R0L2_YERPG

UniProt

A9R0L2 - A9R0L2_YERPG

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Protein

Isocitrate dehydrogenase [NADP]

Gene

icd

Organism
Yersinia pestis bv. Antiqua (strain Angola)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit.UniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciYPES349746:GHPB-2854-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Name:icdImported
Ordered Locus Names:YpAngola_A2848Imported
OrganismiYersinia pestis bv. Antiqua (strain Angola)Imported
Taxonomic identifieri349746 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000001204: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi349746.YpAngola_A2848.

Structurei

3D structure databases

ProteinModelPortaliA9R0L2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0538.
HOGENOMiHOG000021113.
KOiK00031.
OMAiCLRPIRY.
OrthoDBiEOG6SNDTP.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9R0L2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MESKVVVPAE GKKITVDAQG KLVVPHNPII PFIEGDGIGV DVTPAMINVV
60 70 80 90 100
DAAVKKAYNG ERKISWMEIY TGEKSTHVYG KDVWLPEETL DLIRDYRVAI
110 120 130 140 150
KGPLTTPVGG GIRSLNVALR QQLDLYVCLR PVRYYEGTPS PVKHPELTNM
160 170 180 190 200
VIFRENAEDI YAGIEWKAGS PEAEKVIKFL REEMGVKKIR FPEQCGIGVK
210 220 230 240 250
PCSEEGTKRL VRAAIEYAIT NDRESVTLVH KGNIMKFTEG AFKDWGYQLA
260 270 280 290 300
REEFGGELID GGPWVKIKNP NNGKEIIVKD VIADAFLQQI LLRPAEYDVI
310 320 330 340 350
ACMNLNGDYI SDALAAQVGG IGIAPGANIG DDCALFEATH GTAPKYAGQD
360 370 380 390 400
KVNPGSIILS AEMMLRHMGW FEAADLIIKG TEGAIQAKTV TYDFERLMEG
410
AKLLKCSEFG DAIIKHM
Length:417
Mass (Da):45,868
Last modified:February 5, 2008 - v1
Checksum:iF908FB962F0F4932
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000901 Genomic DNA. Translation: ABX86689.1.
RefSeqiYP_001607230.1. NC_010159.1.

Genome annotation databases

EnsemblBacteriaiABX86689; ABX86689; YpAngola_A2848.
GeneIDi5801320.
KEGGiypg:YpAngola_A2848.
PATRICi18575207. VBIYerPes97331_3366.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000901 Genomic DNA. Translation: ABX86689.1 .
RefSeqi YP_001607230.1. NC_010159.1.

3D structure databases

ProteinModelPortali A9R0L2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 349746.YpAngola_A2848.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABX86689 ; ABX86689 ; YpAngola_A2848 .
GeneIDi 5801320.
KEGGi ypg:YpAngola_A2848.
PATRICi 18575207. VBIYerPes97331_3366.

Phylogenomic databases

eggNOGi COG0538.
HOGENOMi HOG000021113.
KOi K00031.
OMAi CLRPIRY.
OrthoDBi EOG6SNDTP.

Enzyme and pathway databases

BioCyci YPES349746:GHPB-2854-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11835. PTHR11835. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the deep-rooted Yersinia pestis strain Angola reveals new insights into the evolution and pangenome of the plague bacterium."
    Eppinger M., Worsham P.L., Nikolich M.P., Riley D.R., Sebastian Y., Mou S., Achtman M., Lindler L.E., Ravel J.
    J. Bacteriol. 192:1685-1699(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AngolaImported.

Entry informationi

Entry nameiA9R0L2_YERPG
AccessioniPrimary (citable) accession number: A9R0L2
Entry historyi
Integrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: October 29, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3