ID   MDTK_YERPG              Reviewed;         457 AA.
AC   A9QZC0;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   27-MAR-2024, entry version 83.
DE   RecName: Full=Multidrug resistance protein MdtK {ECO:0000255|HAMAP-Rule:MF_00400};
DE   AltName: Full=Multidrug-efflux transporter {ECO:0000255|HAMAP-Rule:MF_00400};
GN   Name=mdtK {ECO:0000255|HAMAP-Rule:MF_00400};
GN   OrderedLocusNames=YpAngola_A2579;
OS   Yersinia pestis bv. Antiqua (strain Angola).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=349746;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Angola;
RX   PubMed=20061468; DOI=10.1128/jb.01518-09;
RA   Eppinger M., Worsham P.L., Nikolich M.P., Riley D.R., Sebastian Y., Mou S.,
RA   Achtman M., Lindler L.E., Ravel J.;
RT   "Genome sequence of the deep-rooted Yersinia pestis strain Angola reveals
RT   new insights into the evolution and pangenome of the plague bacterium.";
RL   J. Bacteriol. 192:1685-1699(2010).
CC   -!- FUNCTION: Multidrug efflux pump that functions probably as a Na(+)/drug
CC       antiporter. {ECO:0000255|HAMAP-Rule:MF_00400}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_00400}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_00400}.
CC   -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE)
CC       (TC 2.A.66.1) family. MdtK subfamily. {ECO:0000255|HAMAP-
CC       Rule:MF_00400}.
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DR   EMBL; CP000901; ABX86849.1; -; Genomic_DNA.
DR   RefSeq; WP_002210937.1; NZ_CP009935.1.
DR   AlphaFoldDB; A9QZC0; -.
DR   SMR; A9QZC0; -.
DR   GeneID; 66841264; -.
DR   KEGG; ypg:YpAngola_A2579; -.
DR   PATRIC; fig|349746.12.peg.3605; -.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-UniRule.
DR   GO; GO:0006855; P:xenobiotic transmembrane transport; IEA:UniProtKB-UniRule.
DR   CDD; cd13131; MATE_NorM_like; 1.
DR   HAMAP; MF_00400; MdtK; 1.
DR   InterPro; IPR002528; MATE_fam.
DR   InterPro; IPR048279; MdtK-like.
DR   InterPro; IPR022913; Multidrug-R_MdtK.
DR   NCBIfam; TIGR00797; matE; 1.
DR   PANTHER; PTHR43298:SF2; FMN_FAD EXPORTER YEEO-RELATED; 1.
DR   PANTHER; PTHR43298; MULTIDRUG RESISTANCE PROTEIN NORM-RELATED; 1.
DR   Pfam; PF01554; MatE; 2.
DR   PIRSF; PIRSF006603; DinF; 1.
PE   3: Inferred from homology;
KW   Antiport; Cell inner membrane; Cell membrane; Ion transport; Membrane;
KW   Sodium; Sodium transport; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..457
FT                   /note="Multidrug resistance protein MdtK"
FT                   /id="PRO_1000191109"
FT   TRANSMEM        11..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00400"
FT   TRANSMEM        46..66
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00400"
FT   TRANSMEM        93..113
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00400"
FT   TRANSMEM        127..147
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00400"
FT   TRANSMEM        160..180
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00400"
FT   TRANSMEM        188..208
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00400"
FT   TRANSMEM        243..263
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00400"
FT   TRANSMEM        283..301
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00400"
FT   TRANSMEM        316..336
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00400"
FT   TRANSMEM        357..377
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00400"
FT   TRANSMEM        387..407
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00400"
FT   TRANSMEM        418..438
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00400"
SQ   SEQUENCE   457 AA;  49401 MW;  AF81A08BC3B47987 CRC64;
     MQKYIVEARS LLALAIPVVI AQLSQTAMGV VDTIMAGSVS ATDMAAVAVG TSIWLPAILF
     GHGLLLALTP TVAQLNGSGR RSQIAHQVRQ GFWLALCVSV LIMLVLYNSD HVIKQMDNID
     PVLAQKAVGF LHAIMWGVPG YLFFQVLRNQ CEGLSKTKPG MVIGFVGLLV NIPINYIFIY
     GKFGAPALGG VGCGVATASV YWVMFLMMRW YVTRARSQQD IKLEKGFAAP DWQVMKRLSG
     LGLPVALALF FEVTLFAVVA LLVSPLGIVA VAGHQIALNF SSLMFMLPMS LSVAATIRVG
     FRLGQGAVEQ AQVAAYTSMA VGLLLASVTA VFTIVFREHI ALLYNKTPEV VTMASHLMLL
     AALYQLSDAV QVIGSGVLRG YKDTRSIFFI TFTAYWLLGL PSGYLLGLTD YILPAMGPAG
     FWIGFIIGLT AAAILMVLRI RWLQKQPTAF ILQRAAH
//