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A9QZC0

- MDTK_YERPG

UniProt

A9QZC0 - MDTK_YERPG

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Protein
Multidrug resistance protein MdtK
Gene
mdtK, YpAngola_A2579
Organism
Yersinia pestis bv. Antiqua (strain Angola)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Multidrug efflux pump that functions probably as a Na+/drug antiporter By similarity.UniRule annotation

GO - Molecular functioni

  1. antiporter activity Source: UniProtKB-HAMAP
  2. drug transmembrane transporter activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. sodium ion transport Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Biological processi

Antiport, Ion transport, Sodium transport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

BioCyciYPES349746:GHPB-2584-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug resistance protein MdtK
Alternative name(s):
Multidrug-efflux transporter
Gene namesi
Name:mdtK
Ordered Locus Names:YpAngola_A2579
OrganismiYersinia pestis bv. Antiqua (strain Angola)
Taxonomic identifieri349746 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000001204: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei11 – 3121Helical; Reviewed prediction
Add
BLAST
Transmembranei46 – 6621Helical; Reviewed prediction
Add
BLAST
Transmembranei93 – 11321Helical; Reviewed prediction
Add
BLAST
Transmembranei127 – 14721Helical; Reviewed prediction
Add
BLAST
Transmembranei160 – 18021Helical; Reviewed prediction
Add
BLAST
Transmembranei188 – 20821Helical; Reviewed prediction
Add
BLAST
Transmembranei243 – 26321Helical; Reviewed prediction
Add
BLAST
Transmembranei283 – 30119Helical; Reviewed prediction
Add
BLAST
Transmembranei316 – 33621Helical; Reviewed prediction
Add
BLAST
Transmembranei357 – 37721Helical; Reviewed prediction
Add
BLAST
Transmembranei387 – 40721Helical; Reviewed prediction
Add
BLAST
Transmembranei418 – 43821Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 457457Multidrug resistance protein MdtKUniRule annotation
PRO_1000191109Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi349746.YpAngola_A2579.

Structurei

3D structure databases

ProteinModelPortaliA9QZC0.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0534.
HOGENOMiHOG000038538.
KOiK03327.
OMAiGGVGCGW.
OrthoDBiEOG6423C5.

Family and domain databases

HAMAPiMF_00400. MdtK.
InterProiIPR002528. MATE.
IPR022913. Multidrug-R_MdtK.
[Graphical view]
PfamiPF01554. MatE. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00797. matE. 1 hit.

Sequencei

Sequence statusi: Complete.

A9QZC0-1 [UniParc]FASTAAdd to Basket

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MQKYIVEARS LLALAIPVVI AQLSQTAMGV VDTIMAGSVS ATDMAAVAVG    50
TSIWLPAILF GHGLLLALTP TVAQLNGSGR RSQIAHQVRQ GFWLALCVSV 100
LIMLVLYNSD HVIKQMDNID PVLAQKAVGF LHAIMWGVPG YLFFQVLRNQ 150
CEGLSKTKPG MVIGFVGLLV NIPINYIFIY GKFGAPALGG VGCGVATASV 200
YWVMFLMMRW YVTRARSQQD IKLEKGFAAP DWQVMKRLSG LGLPVALALF 250
FEVTLFAVVA LLVSPLGIVA VAGHQIALNF SSLMFMLPMS LSVAATIRVG 300
FRLGQGAVEQ AQVAAYTSMA VGLLLASVTA VFTIVFREHI ALLYNKTPEV 350
VTMASHLMLL AALYQLSDAV QVIGSGVLRG YKDTRSIFFI TFTAYWLLGL 400
PSGYLLGLTD YILPAMGPAG FWIGFIIGLT AAAILMVLRI RWLQKQPTAF 450
ILQRAAH 457
Length:457
Mass (Da):49,401
Last modified:February 5, 2008 - v1
Checksum:iAF81A08BC3B47987
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000901 Genomic DNA. Translation: ABX86849.1.
RefSeqiYP_001606990.1. NC_010159.1.

Genome annotation databases

EnsemblBacteriaiABX86849; ABX86849; YpAngola_A2579.
GeneIDi5801050.
KEGGiypg:YpAngola_A2579.
PATRICi18574589. VBIYerPes97331_3069.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000901 Genomic DNA. Translation: ABX86849.1 .
RefSeqi YP_001606990.1. NC_010159.1.

3D structure databases

ProteinModelPortali A9QZC0.
ModBasei Search...

Protein-protein interaction databases

STRINGi 349746.YpAngola_A2579.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABX86849 ; ABX86849 ; YpAngola_A2579 .
GeneIDi 5801050.
KEGGi ypg:YpAngola_A2579.
PATRICi 18574589. VBIYerPes97331_3069.

Phylogenomic databases

eggNOGi COG0534.
HOGENOMi HOG000038538.
KOi K03327.
OMAi GGVGCGW.
OrthoDBi EOG6423C5.

Enzyme and pathway databases

BioCyci YPES349746:GHPB-2584-MONOMER.

Family and domain databases

HAMAPi MF_00400. MdtK.
InterProi IPR002528. MATE.
IPR022913. Multidrug-R_MdtK.
[Graphical view ]
Pfami PF01554. MatE. 2 hits.
[Graphical view ]
TIGRFAMsi TIGR00797. matE. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the deep-rooted Yersinia pestis strain Angola reveals new insights into the evolution and pangenome of the plague bacterium."
    Eppinger M., Worsham P.L., Nikolich M.P., Riley D.R., Sebastian Y., Mou S., Achtman M., Lindler L.E., Ravel J.
    J. Bacteriol. 192:1685-1699(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Angola.

Entry informationi

Entry nameiMDTK_YERPG
AccessioniPrimary (citable) accession number: A9QZC0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 5, 2008
Last modified: May 14, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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