A9QZ61 (ASTD_YERPG) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
N-succinylglutamate 5-semialdehyde dehydrogenase
EC=1.2.1.71

Alternative name(s):
Succinylglutamic semialdehyde dehydrogenase
Short name=SGSD

Gene names

Name:	astD
Ordered Locus Names:	YpAngola_A2518

Organism

Yersinia pestis bv. Antiqua (strain Angola) [Complete proteome] [HAMAP]

Taxonomic identifier

349746 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Yersinia

Protein attributes

Sequence length	505 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate By similarity. HAMAP MF_01174
Catalytic activity	N-succinyl-L-glutamate 5-semialdehyde + NAD+ + H2O = N-succinyl-L-glutamate + NADH. HAMAP MF_01174
Pathway	Amino-acid degradation; L-arginine degradation via AST pathway; L-glutamate and succinate from L-arginine: step 4/5. HAMAP MF_01174
Sequence similarities	Belongs to the aldehyde dehydrogenase family. AstD subfamily.

Ontologies

Keywords
Biological process	Arginine metabolism
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	succinylglutamate-semialdehyde dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 505	505	N-succinylglutamate 5-semialdehyde dehydrogenase HAMAP MF_01174		PRO_1000138066
Regions
	Nucleotide binding	234 – 239	6	NAD By similarity
Sites
	Active site	257	1	By similarity
	Active site	291	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	A9QZ61 [UniParc]. Last modified February 5, 2008. Version 1. Checksum: 989EEAA284781632	FASTA	505	54,765
	10 20 30 40 50 60 MSQHVMFNAV LSSHPALFIQ GEWRIGNGVS FEKQDPMSQQ RLWQARAADH TDVTLACHAA 70 80 90 100 110 120 RAAFPAWARA SLEQRATVIQ QFAALLEQHK QSLARTISLE TSKPYWETLT EVQAMIGKVA 130 140 150 160 170 180 ISLQAYQTRT GHSQTPMGDS MSVLRHRPHG VLAVFGPYNF PGHLPNGHIV PALLAGNTVV 190 200 210 220 230 240 FKPSELTPWT AEETVKLWQQ AGIPDGVLNL VQGGRETGEA LAAQPDIDGL LFTGSAHTGY 250 260 270 280 290 300 HLHRQLAGQP EKMLALEMGG NNALIVEQVK DRDAVVNLAI QSAFISAGQR CTCSRRLLVK 310 320 330 340 350 360 TGAEGDAFLL RFTAVAQALR IGRWDEQPAP FMGAVISSQA AERMLAAQQH LLLLGGESLL 370 380 390 400 410 420 NMTRPDSQSA LLTPGIIDIT NISEVPDEEY FGPLVSVIRY TDFTEALKIA NQTRFGLAVG 430 440 450 460 470 480 LVSEDRQQFE QLLLEARAGI VNWNKPLTGA SSAAPFGGVG ASGNHRPSAF YAADYCAWPM 490 500 ASLECEHLTL PATLSPGISF DLPKV

References

[1]

"Genome sequence of the deep-rooted Yersinia pestis strain Angola reveals new insights into the evolution and pangenome of the plague bacterium." Eppinger M., Worsham P.L., Nikolich M.P., Riley D.R., Sebastian Y., Mou S., Achtman M., Lindler L.E., Ravel J. J. Bacteriol. 192:1685-1699(2010) [PubMed: 20061468] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Angola.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000901 Genomic DNA. Translation: ABX86840.1.
RefSeq	YP_001606931.1. NC_010159.1.
3D structure databases
ProteinModelPortal	A9QZ61.
ModBase	Search...
Protein-protein interaction databases
STRING	A9QZ61.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5800988.
GenomeReviews	Gene locus YpAngola_A2518 in contig CP000901_GR.
KEGG	ypg:YpAngola_A2518.
PATRIC	18574459. VBIYerPes97331_3003.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG752218.
OMA	MTQRDPR.
ProtClustDB	PRK09457.
Enzyme and pathway databases
BioCyc	YPES349746:YPANGOLA_A2518-MONOMER.
Family and domain databases
HAMAP	MF_01174. Aldedh_AstD. [Tree]
InterPro	IPR016161. Ald_DH/histidinol_DH. IPR016163. Ald_DH_C. IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH_dom. IPR017649. SuccinylGlu_semiald_DH_AstD. [Graphical view]
Gene3D	G3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit. G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
KO	K06447.
PANTHER	PTHR11699:SF24. PTHR11699:SF24. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
SUPFAM	SSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMs	TIGR03240. Arg_catab_astD. 1 hit.
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ASTD_YERPG

Accession

Primary (citable) accession number: A9QZ61

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	February 5, 2008
Last modified:	January 25, 2012
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program