Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

A9QXB7

- A9QXB7_BOVIN

UniProt

A9QXB7 - A9QXB7_BOVIN

Protein

Interferon gamma

Gene
N/A
Organism
Bos taurus (Bovine)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.UniRule annotation

    GO - Biological processi

    1. defense response to virus Source: UniProtKB-KW
    2. immune response Source: InterPro
    3. regulation of growth Source: UniProtKB-KW

    Keywords - Molecular functioni

    CytokineUniRule annotation

    Keywords - Biological processi

    Antiviral defenseUniRule annotation, Growth regulationUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interferon gammaUniRule annotation
    Short name:
    IFN-gammaUniRule annotation
    OrganismiBos taurus (Bovine)Imported
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

    Subcellular locationi

    Secreted UniRule annotation

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    SecretedUniRule annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the type II (or gamma) interferon family.UniRule annotation

    Phylogenomic databases

    HOVERGENiHBG056912.
    InParanoidiA9QXB7.
    KOiK04687.

    Family and domain databases

    Gene3Di1.20.1250.10. 1 hit.
    InterProiIPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR002069. Interferon_gamma.
    [Graphical view]
    PANTHERiPTHR11419. PTHR11419. 1 hit.
    PfamiPF00714. IFN-gamma. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001936. IFN-gamma. 1 hit.
    ProDomiPD002435. Interferon_gamma. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF47266. SSF47266. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A9QXB7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKYTSYFLAL LLCGLLGFSG SYGQGQFFRE IENLKEYFNA SSPDVAKGGP    50
    LFSEILKNWK DESDKKIIQS QIVSFYFKLF ENLKDNQVIQ RSMDIIKQDM 100
    FQKFLNGSSE KLEDFKKLIQ IPVDDLQIQR KAINELIKVM NDLSPKSNLR 150
    KRKRSQNLFR GRRAST 166
    Length:166
    Mass (Da):19,363
    Last modified:February 5, 2008 - v1
    Checksum:i308268B950BB3B1F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EU277737 mRNA. Translation: ABX75548.1.
    FJ263670 mRNA. Translation: ACI49698.1.
    RefSeqiNP_776511.1. NM_174086.1.
    UniGeneiBt.188.

    Genome annotation databases

    GeneIDi281237.
    KEGGibta:281237.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EU277737 mRNA. Translation: ABX75548.1 .
    FJ263670 mRNA. Translation: ACI49698.1 .
    RefSeqi NP_776511.1. NM_174086.1.
    UniGenei Bt.188.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 281237.
    KEGGi bta:281237.

    Organism-specific databases

    CTDi 3458.

    Phylogenomic databases

    HOVERGENi HBG056912.
    InParanoidi A9QXB7.
    KOi K04687.

    Miscellaneous databases

    NextBioi 20805283.

    Family and domain databases

    Gene3Di 1.20.1250.10. 1 hit.
    InterProi IPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR002069. Interferon_gamma.
    [Graphical view ]
    PANTHERi PTHR11419. PTHR11419. 1 hit.
    Pfami PF00714. IFN-gamma. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001936. IFN-gamma. 1 hit.
    ProDomi PD002435. Interferon_gamma. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF47266. SSF47266. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and sequence analysis of the interferon gamma gene of Chinese cow."
      Qiao J., Chen C., Meng Q.
      Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    2. "Expression of bovine interferon gamma in eukaryotic cells."
      Nikbakht G.H., Jalali A.H., Emam S.M.
      Submitted (SEP-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiA9QXB7_BOVIN
    AccessioniPrimary (citable) accession number: A9QXB7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 5, 2008
    Last sequence update: February 5, 2008
    Last modified: October 1, 2014
    This is version 39 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)