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Protein

Interferon gamma

Gene
N/A
Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.UniRule annotation

GO - Biological processi

  1. defense response to virus Source: UniProtKB-KW
  2. immune response Source: InterPro
  3. regulation of growth Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

CytokineUniRule annotation

Keywords - Biological processi

Antiviral defenseUniRule annotation, Growth regulationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon gammaUniRule annotation
Short name:
IFN-gammaUniRule annotation
OrganismiBos taurus (Bovine)Imported
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Subcellular locationi

Secreted UniRule annotation

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

SecretedUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA9QXB7.
SMRiA9QXB7. Positions 24-144.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the type II (or gamma) interferon family.UniRule annotation

Phylogenomic databases

HOVERGENiHBG056912.
KOiK04687.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR002069. Interferon_gamma.
[Graphical view]
PANTHERiPTHR11419. PTHR11419. 1 hit.
PfamiPF00714. IFN-gamma. 1 hit.
[Graphical view]
PIRSFiPIRSF001936. IFN-gamma. 1 hit.
ProDomiPD002435. Interferon_gamma. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF47266. SSF47266. 1 hit.

Sequencei

Sequence statusi: Complete.

A9QXB7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKYTSYFLAL LLCGLLGFSG SYGQGQFFRE IENLKEYFNA SSPDVAKGGP
60 70 80 90 100
LFSEILKNWK DESDKKIIQS QIVSFYFKLF ENLKDNQVIQ RSMDIIKQDM
110 120 130 140 150
FQKFLNGSSE KLEDFKKLIQ IPVDDLQIQR KAINELIKVM NDLSPKSNLR
160
KRKRSQNLFR GRRAST
Length:166
Mass (Da):19,363
Last modified:February 5, 2008 - v1
Checksum:i308268B950BB3B1F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU277737 mRNA. Translation: ABX75548.1.
FJ263670 mRNA. Translation: ACI49698.1.
RefSeqiNP_776511.1. NM_174086.1.
UniGeneiBt.188.

Genome annotation databases

GeneIDi281237.
KEGGibta:281237.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU277737 mRNA. Translation: ABX75548.1.
FJ263670 mRNA. Translation: ACI49698.1.
RefSeqiNP_776511.1. NM_174086.1.
UniGeneiBt.188.

3D structure databases

ProteinModelPortaliA9QXB7.
SMRiA9QXB7. Positions 24-144.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi281237.
KEGGibta:281237.

Organism-specific databases

CTDi3458.

Phylogenomic databases

HOVERGENiHBG056912.
KOiK04687.

Miscellaneous databases

NextBioi20805283.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR002069. Interferon_gamma.
[Graphical view]
PANTHERiPTHR11419. PTHR11419. 1 hit.
PfamiPF00714. IFN-gamma. 1 hit.
[Graphical view]
PIRSFiPIRSF001936. IFN-gamma. 1 hit.
ProDomiPD002435. Interferon_gamma. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF47266. SSF47266. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Cloning and sequence analysis of the interferon gamma gene of Chinese cow."
    Qiao J., Chen C., Meng Q.
    Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Expression of bovine interferon gamma in eukaryotic cells."
    Nikbakht G.H., Jalali A.H., Emam S.M.
    Submitted (SEP-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiA9QXB7_BOVIN
AccessioniPrimary (citable) accession number: A9QXB7
Entry historyi
Integrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: October 29, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.