Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A9QXB7

- A9QXB7_BOVIN

UniProt

A9QXB7 - A9QXB7_BOVIN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Interferon gamma

Gene
N/A
Organism
Bos taurus (Bovine)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.UniRule annotation

GO - Biological processi

  1. defense response to virus Source: UniProtKB-KW
  2. immune response Source: InterPro
  3. regulation of growth Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

CytokineUniRule annotation

Keywords - Biological processi

Antiviral defenseUniRule annotation, Growth regulationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon gammaUniRule annotation
Short name:
IFN-gammaUniRule annotation
OrganismiBos taurus (Bovine)Imported
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Subcellular locationi

Secreted UniRule annotation

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

SecretedUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA9QXB7.
SMRiA9QXB7. Positions 24-144.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the type II (or gamma) interferon family.UniRule annotation

Phylogenomic databases

HOVERGENiHBG056912.
KOiK04687.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR002069. Interferon_gamma.
[Graphical view]
PANTHERiPTHR11419. PTHR11419. 1 hit.
PfamiPF00714. IFN-gamma. 1 hit.
[Graphical view]
PIRSFiPIRSF001936. IFN-gamma. 1 hit.
ProDomiPD002435. Interferon_gamma. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF47266. SSF47266. 1 hit.

Sequencei

Sequence statusi: Complete.

A9QXB7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKYTSYFLAL LLCGLLGFSG SYGQGQFFRE IENLKEYFNA SSPDVAKGGP
60 70 80 90 100
LFSEILKNWK DESDKKIIQS QIVSFYFKLF ENLKDNQVIQ RSMDIIKQDM
110 120 130 140 150
FQKFLNGSSE KLEDFKKLIQ IPVDDLQIQR KAINELIKVM NDLSPKSNLR
160
KRKRSQNLFR GRRAST
Length:166
Mass (Da):19,363
Last modified:February 5, 2008 - v1
Checksum:i308268B950BB3B1F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU277737 mRNA. Translation: ABX75548.1.
FJ263670 mRNA. Translation: ACI49698.1.
RefSeqiNP_776511.1. NM_174086.1.
UniGeneiBt.188.

Genome annotation databases

GeneIDi281237.
KEGGibta:281237.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU277737 mRNA. Translation: ABX75548.1 .
FJ263670 mRNA. Translation: ACI49698.1 .
RefSeqi NP_776511.1. NM_174086.1.
UniGenei Bt.188.

3D structure databases

ProteinModelPortali A9QXB7.
SMRi A9QXB7. Positions 24-144.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 281237.
KEGGi bta:281237.

Organism-specific databases

CTDi 3458.

Phylogenomic databases

HOVERGENi HBG056912.
KOi K04687.

Miscellaneous databases

NextBioi 20805283.

Family and domain databases

Gene3Di 1.20.1250.10. 1 hit.
InterProi IPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR002069. Interferon_gamma.
[Graphical view ]
PANTHERi PTHR11419. PTHR11419. 1 hit.
Pfami PF00714. IFN-gamma. 1 hit.
[Graphical view ]
PIRSFi PIRSF001936. IFN-gamma. 1 hit.
ProDomi PD002435. Interferon_gamma. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF47266. SSF47266. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Cloning and sequence analysis of the interferon gamma gene of Chinese cow."
    Qiao J., Chen C., Meng Q.
    Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Expression of bovine interferon gamma in eukaryotic cells."
    Nikbakht G.H., Jalali A.H., Emam S.M.
    Submitted (SEP-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiA9QXB7_BOVIN
AccessioniPrimary (citable) accession number: A9QXB7
Entry historyi
Integrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: October 29, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)