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A9QXB7

- A9QXB7_BOVIN

UniProt

A9QXB7 - A9QXB7_BOVIN

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Protein
Interferon gamma
Gene
N/A
Organism
Bos taurus (Bovine)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons By similarity.UniRule annotation

GO - Biological processi

  1. defense response to virus Source: UniProtKB-KW
  2. immune response Source: InterPro
  3. regulation of growth Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

CytokineUniRule annotation

Keywords - Biological processi

Antiviral defenseUniRule annotation, Growth regulationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon gammaUniRule annotation
Short name:
IFN-gammaUniRule annotation
OrganismiBos taurus (Bovine)Imported
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Subcellular locationi

Secreted By similarity UniRule annotation

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

SecretedUniRule annotation

PTM / Processingi

Proteomic databases

PRIDEiA9QXB7.

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA9QXB7.
SMRiA9QXB7. Positions 24-144.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG056912.
InParanoidiA9QXB7.
KOiK04687.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR002069. Interferon_gamma.
[Graphical view]
PANTHERiPTHR11419. PTHR11419. 1 hit.
PfamiPF00714. IFN-gamma. 1 hit.
[Graphical view]
PIRSFiPIRSF001936. IFN-gamma. 1 hit.
ProDomiPD002435. Interferon_gamma. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF47266. SSF47266. 1 hit.

Sequencei

Sequence statusi: Complete.

A9QXB7-1 [UniParc]FASTAAdd to Basket

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MKYTSYFLAL LLCGLLGFSG SYGQGQFFRE IENLKEYFNA SSPDVAKGGP    50
LFSEILKNWK DESDKKIIQS QIVSFYFKLF ENLKDNQVIQ RSMDIIKQDM 100
FQKFLNGSSE KLEDFKKLIQ IPVDDLQIQR KAINELIKVM NDLSPKSNLR 150
KRKRSQNLFR GRRAST 166
Length:166
Mass (Da):19,363
Last modified:February 5, 2008 - v1
Checksum:i308268B950BB3B1F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EU277737 mRNA. Translation: ABX75548.1.
FJ263670 mRNA. Translation: ACI49698.1.
RefSeqiNP_776511.1. NM_174086.1.
UniGeneiBt.188.

Genome annotation databases

GeneIDi281237.
KEGGibta:281237.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EU277737 mRNA. Translation: ABX75548.1 .
FJ263670 mRNA. Translation: ACI49698.1 .
RefSeqi NP_776511.1. NM_174086.1.
UniGenei Bt.188.

3D structure databases

ProteinModelPortali A9QXB7.
SMRi A9QXB7. Positions 24-144.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi A9QXB7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 281237.
KEGGi bta:281237.

Organism-specific databases

CTDi 3458.

Phylogenomic databases

HOVERGENi HBG056912.
InParanoidi A9QXB7.
KOi K04687.

Miscellaneous databases

NextBioi 20805283.

Family and domain databases

Gene3Di 1.20.1250.10. 1 hit.
InterProi IPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR002069. Interferon_gamma.
[Graphical view ]
PANTHERi PTHR11419. PTHR11419. 1 hit.
Pfami PF00714. IFN-gamma. 1 hit.
[Graphical view ]
PIRSFi PIRSF001936. IFN-gamma. 1 hit.
ProDomi PD002435. Interferon_gamma. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF47266. SSF47266. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Cloning and sequence analysis of the interferon gamma gene of Chinese cow."
    Qiao J., Chen C., Meng Q.
    Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Expression of bovine interferon gamma in eukaryotic cells."
    Nikbakht G.H., Jalali A.H., Emam S.M.
    Submitted (SEP-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiA9QXB7_BOVIN
AccessioniPrimary (citable) accession number: A9QXB7
Entry historyi
Integrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: January 22, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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