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Protein

Importin subunit alpha-8

Gene

KPNA7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Functions in nuclear protein import.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-1169408. ISG15 antiviral mechanism.
R-HSA-168276. NS1 Mediated Effects on Host Pathways.
SignaLinkiA9QM74.

Names & Taxonomyi

Protein namesi
Recommended name:
Importin subunit alpha-8
Alternative name(s):
Karyopherin subunit alpha-7
Gene namesi
Name:KPNA7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:21839. KPNA7.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

MalaCardsiKPNA7.
Orphaneti401959. Partial corpus callosum agenesis-cerebellar vermis hypoplasia with posterior fossa cysts syndrome.
PharmGKBiPA164722048.

Polymorphism and mutation databases

BioMutaiKPNA7.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 516516Importin subunit alpha-8PRO_0000326082Add
BLAST

Proteomic databases

PaxDbiA9QM74.
PRIDEiA9QM74.

PTM databases

PhosphoSiteiA9QM74.

Expressioni

Gene expression databases

BgeeiA9QM74.

Organism-specific databases

HPAiHPA031395.

Interactioni

Subunit structurei

Binds very efficiently to importin subunit beta-1/KPNB1 via the IBB domain; this complex dissociates in the presence of RAN-GTP. Shows a limited binding to the RB1 nuclear localization signal (NLS), but not to the SV40, nor NPM1 NLSs.

Protein-protein interaction databases

BioGridi135514. 1 interaction.
STRINGi9606.ENSP00000330878.

Structurei

3D structure databases

ProteinModelPortaliA9QM74.
SMRiA9QM74. Positions 10-486.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 5757IBBPROSITE-ProRule annotationAdd
BLAST
Repeati103 – 14341ARM 1Add
BLAST
Repeati146 – 18540ARM 2Add
BLAST
Repeati188 – 22841ARM 3Add
BLAST
Repeati231 – 27040ARM 4Add
BLAST
Repeati273 – 31240ARM 5Add
BLAST
Repeati315 – 35440ARM 6Add
BLAST
Repeati357 – 39640ARM 7Add
BLAST
Repeati400 – 43940ARM 8Add
BLAST

Sequence similaritiesi

Belongs to the importin alpha family.Curated
Contains 8 ARM repeats.PROSITE-ProRule annotation
Contains 1 IBB domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0166. Eukaryota.
COG5064. LUCA.
GeneTreeiENSGT00760000119094.
HOGENOMiHOG000167616.
HOVERGENiHBG001846.
InParanoidiA9QM74.
OMAiNKNPYPC.
OrthoDBiEOG7VHSWV.
PhylomeDBiA9QM74.
TreeFamiTF101178.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR032413. Arm_3.
IPR000225. Armadillo.
IPR002652. Importin-a_IBB.
IPR024931. Importing_su_alpha.
[Graphical view]
PfamiPF00514. Arm. 7 hits.
PF16186. Arm_3. 1 hit.
PF01749. IBB. 1 hit.
[Graphical view]
PIRSFiPIRSF005673. Importin_alpha. 1 hit.
SMARTiSM00185. ARM. 8 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50176. ARM_REPEAT. 5 hits.
PS51214. IBB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9QM74-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPTLDAPEER RRKFKYRGKD VSLRRQQRMA VSLELRKAKK DEQTLKRRNI
60 70 80 90 100
TSFCPDTPSE KTAKGVAVSL TLGEIIKGVN SSDPVLCFQA TQTARKMLSQ
110 120 130 140 150
EKNPPLKLVI EAGLIPRMVE FLKSSLYPCL QFEAAWALTN IASGTSEQTR
160 170 180 190 200
AVVEGGAIQP LIELLSSSNV AVCEQAVWAL GNIAGDGPEF RDNVITSNAI
210 220 230 240 250
PHLLALISPT LPITFLRNIT WTLSNLCRNK NPYPCDTAVK QILPALLHLL
260 270 280 290 300
QHQDSEVLSD ACWALSYLTD GSNKRIGQVV NTGVLPRLVV LMTSSELNVL
310 320 330 340 350
TPSLRTVGNI VTGTDEQTQM AIDAGMLNVL PQLLQHNKPS IQKEAAWALS
360 370 380 390 400
NVAAGPCHHI QQLLAYDVLP PLVALLKNGE FKVQKEAVWM VANFATGATM
410 420 430 440 450
DQLIQLVHSG VLEPLVNLLT APDVKIVLII LDVISCILQA AEKRSEKENL
460 470 480 490 500
CLLIEELGGI DRIEALQLHE NRQIGQSALN IIEKHFGEEE DESQTLLSQV
510
IDQDYEFIDY ECLAKK
Length:516
Mass (Da):56,938
Last modified:February 5, 2008 - v1
Checksum:i803D7CC662C09378
GO

Sequence cautioni

The sequence EAL23884.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU126604 mRNA. Translation: ABW96272.1.
CH236956 Genomic DNA. Translation: EAL23884.1. Different initiation.
CCDSiCCDS47651.1.
RefSeqiNP_001139187.1. NM_001145715.1.
XP_006716050.1. XM_006715987.2.
XP_011514520.1. XM_011516218.1.
XP_011514521.1. XM_011516219.1.
XP_011514522.1. XM_011516220.1.
UniGeneiHs.253050.

Genome annotation databases

EnsembliENST00000327442; ENSP00000330878; ENSG00000185467.
GeneIDi402569.
KEGGihsa:402569.
UCSCiuc010lft.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU126604 mRNA. Translation: ABW96272.1.
CH236956 Genomic DNA. Translation: EAL23884.1. Different initiation.
CCDSiCCDS47651.1.
RefSeqiNP_001139187.1. NM_001145715.1.
XP_006716050.1. XM_006715987.2.
XP_011514520.1. XM_011516218.1.
XP_011514521.1. XM_011516219.1.
XP_011514522.1. XM_011516220.1.
UniGeneiHs.253050.

3D structure databases

ProteinModelPortaliA9QM74.
SMRiA9QM74. Positions 10-486.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi135514. 1 interaction.
STRINGi9606.ENSP00000330878.

PTM databases

PhosphoSiteiA9QM74.

Polymorphism and mutation databases

BioMutaiKPNA7.

Proteomic databases

PaxDbiA9QM74.
PRIDEiA9QM74.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000327442; ENSP00000330878; ENSG00000185467.
GeneIDi402569.
KEGGihsa:402569.
UCSCiuc010lft.3. human.

Organism-specific databases

CTDi402569.
GeneCardsiKPNA7.
HGNCiHGNC:21839. KPNA7.
HPAiHPA031395.
MalaCardsiKPNA7.
MIMi614107. gene.
neXtProtiNX_A9QM74.
Orphaneti401959. Partial corpus callosum agenesis-cerebellar vermis hypoplasia with posterior fossa cysts syndrome.
PharmGKBiPA164722048.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0166. Eukaryota.
COG5064. LUCA.
GeneTreeiENSGT00760000119094.
HOGENOMiHOG000167616.
HOVERGENiHBG001846.
InParanoidiA9QM74.
OMAiNKNPYPC.
OrthoDBiEOG7VHSWV.
PhylomeDBiA9QM74.
TreeFamiTF101178.

Enzyme and pathway databases

ReactomeiR-HSA-1169408. ISG15 antiviral mechanism.
R-HSA-168276. NS1 Mediated Effects on Host Pathways.
SignaLinkiA9QM74.

Miscellaneous databases

GenomeRNAii402569.
NextBioi107537.
PROiA9QM74.
SOURCEiSearch...

Gene expression databases

BgeeiA9QM74.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR032413. Arm_3.
IPR000225. Armadillo.
IPR002652. Importin-a_IBB.
IPR024931. Importing_su_alpha.
[Graphical view]
PfamiPF00514. Arm. 7 hits.
PF16186. Arm_3. 1 hit.
PF01749. IBB. 1 hit.
[Graphical view]
PIRSFiPIRSF005673. Importin_alpha. 1 hit.
SMARTiSM00185. ARM. 8 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50176. ARM_REPEAT. 5 hits.
PS51214. IBB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Karyopherin alpha7 (KPNA7), a divergent member of the importin alpha family of nuclear import receptors."
    Kelley J.B., Talley A.M., Spencer A., Gioeli D., Paschal B.M.
    BMC Cell Biol. 11:63-63(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, INTERACTION WITH KPNB1 AND RB1.
    Tissue: Prostatic adenocarcinoma.
  2. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiIMA8_HUMAN
AccessioniPrimary (citable) accession number: A9QM74
Secondary accession number(s): A4D277
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: February 5, 2008
Last modified: March 16, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.