A9Q1L2 (NSP5_ROTB2) Reviewed, UniProtKB/Swiss-Prot
Last modified January 19, 2010. Version 14. History...
Names and origin
|Protein names||Recommended name:|
Non-structural protein 5
|Organism||Rotavirus (isolate Human/Bangladesh/ADRV-N B219/2002) (RV ADRV-N) (Rotavirus (isolate novel adult diarrhea rotavirus-B219)) [Complete proteome]|
|Taxonomic identifier||348136 [NCBI]|
|Taxonomic lineage||Viruses › dsRNA viruses › Reoviridae › Sedoreovirinae › Rotavirus › unclassified rotaviruses|
|Virus host||Homo sapiens (Human) [TaxID: 9606]|
|Sequence length||176 AA.|
|Protein existence||Evidence at transcript level|
General annotation (Comments)
Involved in genome replication. Plays a crucial role, together with NSP2, in the formation of virus factories (viroplasms) which are large inclusions in the cytoplasm where core-like replication intermediates are assembled and RNA replication takes place By similarity.
Homodimer. Interacts with VP1. Interacts with VP2. Interacts with NSP2; this interaction leads to formation of virus factories By similarity.
Host cytoplasm. Note: Found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging By similarity.
Belongs to the rotavirus B NSP5 family.
Sequence annotation (Features)
|||"Whole genomic characterization of a human rotavirus strain B219 belonging to a novel group of the genus Rotavirus."|
Nagashima S., Kobayashi N., Ishino M., Alam M.M., Ahmed M.U., Paul S.K., Ganesh B., Chawla-Sarkar M., Krishnan T., Naik T.N., Wang Y.-H.
J. Med. Virol. 80:2023-2033(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
|EF453360 mRNA. Translation: ABR32127.1.|
3D structure databases
Protocols and materials databases
Family and domain databases
|InterPro||IPR020244. Rotavirus_B_NSP5. |
|ProDom||PD035122. Rotavirus_B_NSP5. 1 hit. |
[Graphical view] [Entries sharing at least one domain]
|Accession||Primary (citable) accession number: A9Q1L2|
|Entry status||Reviewed (UniProtKB/Swiss-Prot)|
|Annotation program||Viral Protein Annotation Program|
Index of protein domains and families