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A9Q1L2 (NSP5_ROTB2) Reviewed, UniProtKB/Swiss-Prot

Last modified January 19, 2010. Version 14. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein attributes

Sequence length176 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Involved in genome replication. Plays a crucial role, together with NSP2, in the formation of virus factories (viroplasms) which are large inclusions in the cytoplasm where core-like replication intermediates are assembled and RNA replication takes place By similarity.

Subunit structure

Homodimer. Interacts with VP1. Interacts with VP2. Interacts with NSP2; this interaction leads to formation of virus factories By similarity.

Subcellular location

Host cytoplasm. Note: Found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging By similarity.

Sequence similarities

Belongs to the rotavirus B NSP5 family.

Ontologies

Keywords
   Cellular componentHost cytoplasm
   DomainCoiled coil
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componenthost cell cytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 176176Non-structural protein 5
PRO_0000369867

Regions

Coiled coil92 – 13948 Potential

Sequences

Sequence LengthMass (Da)Tools
A9Q1L2 [UniParc].

Last modified February 5, 2008. Version 1.
Checksum: 62440F06123845AD

FASTA17620,216
        10         20         30         40         50         60 
MSEVPRFELR NKRKVGKKQK VDIFGDKDDE SMLQIDCETD SLISESVSST HSYEDYSKAY 

        70         80         90        100        110        120 
KELTLETPAD TNDSTSTIID SAYEESWYDK TIKDEQTKEN KKTDKKLKRI ENIKENNQND 

       130        140        150        160        170 
STSMQIAQLS LRIQRIESET KLKTLDSAYN TIITQADNLT TPQKKSLISA ILATMR 

« Hide

References

[1]"Whole genomic characterization of a human rotavirus strain B219 belonging to a novel group of the genus Rotavirus."
Nagashima S., Kobayashi N., Ishino M., Alam M.M., Ahmed M.U., Paul S.K., Ganesh B., Chawla-Sarkar M., Krishnan T., Naik T.N., Wang Y.-H.
J. Med. Virol. 80:2023-2033(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
EF453360 mRNA. Translation: ABR32127.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR020244. Rotavirus_B_NSP5.
[Graphical view]
ProDomPD035122. Rotavirus_B_NSP5. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetSearch...

Entry information

Entry nameNSP5_ROTB2
AccessionPrimary (citable) accession number: A9Q1L2
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 5, 2008
Last modified: January 19, 2010
This is version 14 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families