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A9Q1K8

- VP2_ROTB2

UniProt

A9Q1K8 - VP2_ROTB2

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Protein

Inner capsid protein VP2

Gene
N/A
Organism
Rotavirus (isolate Human/Bangladesh/ADRV-N B219/2002) (RV ADRV-N) (Rotavirus (isolate novel adult diarrhea rotavirus-B219))
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Inner capsid protein that self assembles to form an icosahedral capsid with a T=2 symmetry, which consists of 120 copies of VP2, with channels at each of its five-fold vertices. This capsid constitutes the innermost concentric layer of the viral mature particle. It encapsidates the polymerase VP1, the capping enzyme VP3 and the genomic dsRNA, thereby defining the core. The innermost VP2 capsid and the intermediate VP6 capsid remain intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus. Nacent transcripts are transcribed within the structural confines of this double-layered particle (DLP) and are extruded through the channels at the five-fold axes. VP2 is required for the replicase activity of VP1 polymerase. It probably plays a role in the coordination of packaging and genome replication by controlling the initiation of minus-strand synthesis. Binding to the polymerase VP1 presumably activates the autoinhibited VP1-RNA complex which will start the synthesis of the complementary minus-strand (By similarity).By similarity

GO - Molecular functioni

  1. RNA binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Inner capsid protein VP2
OrganismiRotavirus (isolate Human/Bangladesh/ADRV-N B219/2002) (RV ADRV-N) (Rotavirus (isolate novel adult diarrhea rotavirus-B219))
Taxonomic identifieri348136 [NCBI]
Taxonomic lineageiVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirusunclassified rotaviruses
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000008656: Genome

Subcellular locationi

Virion Curated
Note: Inner capsid protein. Also found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging (By similarity).By similarity

GO - Cellular componenti

  1. viral inner capsid Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Inner capsid protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 973973Inner capsid protein VP2PRO_0000369834Add
BLAST

Interactioni

Subunit structurei

Dimer (Potential). Interacts with VP1. Interacts with VP3. Interacts with NSP5 (By similarity).By similarityCurated

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni449 – 46921HydrophobicAdd
BLAST

Sequence similaritiesi

Belongs to the rotavirus VP2 family.Curated

Sequencei

Sequence statusi: Complete.

A9Q1K8-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MEVIEKLETI RETLNDTKDK KDFQKIHDEL VQYLDGVDSL TIDDDKWNEI
60 70 80 90 100
LKLFKTIIIK LKSSTIKTTP LENELLQHEK KRTVKEVEKV EEDIKTDVTN
110 120 130 140 150
DTSKPTLMDK VLQVSNQPNN PYSADVLQIR TILSKTLFVD TDSEAYSLYV
160 170 180 190 200
PESQKLDVSP ITIELTTIEK YQPKVNILKQ AVIVPSQNPL LADTYGAPEI
210 220 230 240 250
LFSTDFFDDI TSNSSEGLQL YFFDKAYKLK KELPNLPFLS SLDKDVNPLN
260 270 280 290 300
PLNSVCKSFG QEKYYDMVMD RTDRGLDARR AAMQFDNVIV DAQNRTVQFN
310 320 330 340 350
VRMHPFDLQL LRISQQFAEP MQDLAPVVRE YMMLGADGYV LTQKIRLDRD
360 370 380 390 400
QQLIANRRSV VFDRMCELSG PLYRSRIIHS MRMMSKLWRT NVFRTSLEDE
410 420 430 440 450
ITKIYAAAEV SMISIDATTS ALSTINIASA EQTLNALLNM SFFRCELDLI
460 470 480 490 500
GSQSSFGAAM SAMIALMILP TDQENMDDEV FDVLCNLVYN ELIAWAADRP
510 520 530 540 550
VFVRRAGATN AFRQFVNAGL NRDITNYMRF VLLRRPWLPL YNSRDVRRNA
560 570 580 590 600
HVLVPNVDLA NINDQVYVAI NSFLNGIIEA SRRNPNPNKT ISANSFRKLM
610 620 630 640 650
KNMRDICVNR LMPVIRLIRY NVERIGMILH MLPYSADIFD INRNLRDERL
660 670 680 690 700
RIKIPMSGFL SLVMGITKAP DAFDWSQILN FADDVRKMDY AEAISIEDSA
710 720 730 740 750
SVAIMRNDAN RATSKKEIFI SEVRPPTPTV ASIQKIPSAT LTAIFSDRQL
760 770 780 790 800
INLIRDTHSF RVIREIAVAL QAAFDNSPTS QHGVGKGAVL HPVPQNFGRS
810 820 830 840 850
SQFVRRDNIL LQRPAGIQQF TIEDLKQGRY FQGLMAQIRA RQPIIVNGPI
860 870 880 890 900
PLRISDAAEI EQVTLAFLTM NSPYDAYIDP RDLKQQKLLT DREVDLFIDQ
910 920 930 940 950
SPARPNDEFD NVMARTSVFI IDAPRAIVPI NPQRLNFPYH DIMVTDSVTK
960 970
FIEFTVALTP DLQLFNGLLV FEQ
Length:973
Mass (Da):111,085
Last modified:February 5, 2008 - v1
Checksum:i03B08088108FBFD6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EF453356 mRNA. Translation: ABR32123.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EF453356 mRNA. Translation: ABR32123.1 .

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

ProtoNeti Search...

Publicationsi

  1. "Whole genomic characterization of a human rotavirus strain B219 belonging to a novel group of the genus Rotavirus."
    Nagashima S., Kobayashi N., Ishino M., Alam M.M., Ahmed M.U., Paul S.K., Ganesh B., Chawla-Sarkar M., Krishnan T., Naik T.N., Wang Y.-H.
    J. Med. Virol. 80:2023-2033(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiVP2_ROTB2
AccessioniPrimary (citable) accession number: A9Q1K8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 5, 2008
Last modified: October 1, 2014
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3