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A9Q1K8

- VP2_ROTB2

UniProt

A9Q1K8 - VP2_ROTB2

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Protein
Inner capsid protein VP2
Gene
N/A
Organism
Rotavirus (isolate Human/Bangladesh/ADRV-N B219/2002) (RV ADRV-N) (Rotavirus (isolate novel adult diarrhea rotavirus-B219))
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Inner capsid protein that self assembles to form an icosahedral capsid with a T=2 symmetry, which consists of 120 copies of VP2, with channels at each of its five-fold vertices. This capsid constitutes the innermost concentric layer of the viral mature particle. It encapsidates the polymerase VP1, the capping enzyme VP3 and the genomic dsRNA, thereby defining the core. The innermost VP2 capsid and the intermediate VP6 capsid remain intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus. Nacent transcripts are transcribed within the structural confines of this double-layered particle (DLP) and are extruded through the channels at the five-fold axes. VP2 is required for the replicase activity of VP1 polymerase. It probably plays a role in the coordination of packaging and genome replication by controlling the initiation of minus-strand synthesis. Binding to the polymerase VP1 presumably activates the autoinhibited VP1-RNA complex which will start the synthesis of the complementary minus-strand By similarity.

GO - Molecular functioni

  1. RNA binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Inner capsid protein VP2
OrganismiRotavirus (isolate Human/Bangladesh/ADRV-N B219/2002) (RV ADRV-N) (Rotavirus (isolate novel adult diarrhea rotavirus-B219))
Taxonomic identifieri348136 [NCBI]
Taxonomic lineageiVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirusunclassified rotaviruses
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000008656: Genome

Subcellular locationi

Virion Reviewed prediction
Note: Inner capsid protein. Also found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging By similarity.

GO - Cellular componenti

  1. viral inner capsid Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Inner capsid protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 973973Inner capsid protein VP2
PRO_0000369834Add
BLAST

Interactioni

Subunit structurei

Dimer Reviewed prediction. Interacts with VP1. Interacts with VP3. Interacts with NSP5 By similarity.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni449 – 46921Hydrophobic
Add
BLAST

Sequence similaritiesi

Belongs to the rotavirus VP2 family.

Sequencei

Sequence statusi: Complete.

A9Q1K8-1 [UniParc]FASTAAdd to Basket

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MEVIEKLETI RETLNDTKDK KDFQKIHDEL VQYLDGVDSL TIDDDKWNEI    50
LKLFKTIIIK LKSSTIKTTP LENELLQHEK KRTVKEVEKV EEDIKTDVTN 100
DTSKPTLMDK VLQVSNQPNN PYSADVLQIR TILSKTLFVD TDSEAYSLYV 150
PESQKLDVSP ITIELTTIEK YQPKVNILKQ AVIVPSQNPL LADTYGAPEI 200
LFSTDFFDDI TSNSSEGLQL YFFDKAYKLK KELPNLPFLS SLDKDVNPLN 250
PLNSVCKSFG QEKYYDMVMD RTDRGLDARR AAMQFDNVIV DAQNRTVQFN 300
VRMHPFDLQL LRISQQFAEP MQDLAPVVRE YMMLGADGYV LTQKIRLDRD 350
QQLIANRRSV VFDRMCELSG PLYRSRIIHS MRMMSKLWRT NVFRTSLEDE 400
ITKIYAAAEV SMISIDATTS ALSTINIASA EQTLNALLNM SFFRCELDLI 450
GSQSSFGAAM SAMIALMILP TDQENMDDEV FDVLCNLVYN ELIAWAADRP 500
VFVRRAGATN AFRQFVNAGL NRDITNYMRF VLLRRPWLPL YNSRDVRRNA 550
HVLVPNVDLA NINDQVYVAI NSFLNGIIEA SRRNPNPNKT ISANSFRKLM 600
KNMRDICVNR LMPVIRLIRY NVERIGMILH MLPYSADIFD INRNLRDERL 650
RIKIPMSGFL SLVMGITKAP DAFDWSQILN FADDVRKMDY AEAISIEDSA 700
SVAIMRNDAN RATSKKEIFI SEVRPPTPTV ASIQKIPSAT LTAIFSDRQL 750
INLIRDTHSF RVIREIAVAL QAAFDNSPTS QHGVGKGAVL HPVPQNFGRS 800
SQFVRRDNIL LQRPAGIQQF TIEDLKQGRY FQGLMAQIRA RQPIIVNGPI 850
PLRISDAAEI EQVTLAFLTM NSPYDAYIDP RDLKQQKLLT DREVDLFIDQ 900
SPARPNDEFD NVMARTSVFI IDAPRAIVPI NPQRLNFPYH DIMVTDSVTK 950
FIEFTVALTP DLQLFNGLLV FEQ 973
Length:973
Mass (Da):111,085
Last modified:February 5, 2008 - v1
Checksum:i03B08088108FBFD6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EF453356 mRNA. Translation: ABR32123.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EF453356 mRNA. Translation: ABR32123.1 .

3D structure databases

ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

ProtoNeti Search...

Publicationsi

  1. "Whole genomic characterization of a human rotavirus strain B219 belonging to a novel group of the genus Rotavirus."
    Nagashima S., Kobayashi N., Ishino M., Alam M.M., Ahmed M.U., Paul S.K., Ganesh B., Chawla-Sarkar M., Krishnan T., Naik T.N., Wang Y.-H.
    J. Med. Virol. 80:2023-2033(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiVP2_ROTB2
AccessioniPrimary (citable) accession number: A9Q1K8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 5, 2008
Last modified: October 16, 2013
This is version 16 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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