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Protein

Bacteriocin ubericin-A

Gene

ubaA

Organism
Streptococcus uberis
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Heat-stable antibiotic with bacteriolytic activity against Listeria spp., E.hirae, E.faecalis ATCC 19433, S.bovis 83, S.uberis 42 and L.lactis.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Bacteriocin

Protein family/group databases

TCDBi1.C.24.1.11. the pediocin (pediocin) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Bacteriocin ubericin-A
Gene namesi
Name:ubaA
OrganismiStreptococcus uberis
Taxonomic identifieri1349 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 21211 PublicationAdd
BLAST
Chaini22 – 7049Bacteriocin ubericin-APRO_5000298104Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi32 ↔ 371 Publication

Post-translational modificationi

The disulfide bond is essential for the activity.

Keywords - PTMi

Disulfide bond

Structurei

3D structure databases

ProteinModelPortaliA9Q0M7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the bacteriocin class IIA/YGNGV family.Curated

Keywords - Domaini

Signal

Family and domain databases

Gene3Di1.20.5.130. 1 hit.
InterProiIPR002633. Bacteriocin_IIa.
IPR023384. Bacteriocin_IIa_CS.
IPR023388. Bacteriocin_IIa_dom.
[Graphical view]
PfamiPF01721. Bacteriocin_II. 1 hit.
[Graphical view]
ProDomiPD004452. Bacteriocin_II. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS60030. BACTERIOCIN_IIA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A9Q0M7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTIEKFENI KLFSLKKIIG GKTVNYGNGL YCNQKKCWVN WSETATTIVN
60 70
NSIMNGLTGG NAGWHSGGRA
Length:70
Mass (Da):7,681
Last modified:February 5, 2008 - v1
Checksum:iA0D25369999041FF
GO

Mass spectrometryi

Molecular mass is 5270.5±5.3 Da from positions 22 - 70. Determined by MALDI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF203953 Genomic DNA. Translation: ABQ23939.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF203953 Genomic DNA. Translation: ABQ23939.1.

3D structure databases

ProteinModelPortaliA9Q0M7.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

TCDBi1.C.24.1.11. the pediocin (pediocin) family.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di1.20.5.130. 1 hit.
InterProiIPR002633. Bacteriocin_IIa.
IPR023384. Bacteriocin_IIa_CS.
IPR023388. Bacteriocin_IIa_dom.
[Graphical view]
PfamiPF01721. Bacteriocin_II. 1 hit.
[Graphical view]
ProDomiPD004452. Bacteriocin_II. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS60030. BACTERIOCIN_IIA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Ubericin A, a class IIa bacteriocin produced by Streptococcus uberis."
    Heng N.C.K., Burtenshaw G.A., Jack R.W., Tagg J.R.
    Appl. Environ. Microbiol. 73:7763-7766(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 22-61, DISULFIDE BOND, MASS SPECTROMETRY.
    Strain: E.

Entry informationi

Entry nameiUBAA_STRUB
AccessioniPrimary (citable) accession number: A9Q0M7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: February 5, 2008
Last modified: December 9, 2015
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.