ID   A9PKC6_9HIV1            Unreviewed;       276 AA.
AC   A9PKC6;
DT   05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT   05-FEB-2008, sequence version 1.
DT   24-JAN-2024, entry version 67.
DE   SubName: Full=Gag protein {ECO:0000313|EMBL:ABO61558.1};
DE   Flags: Fragment;
GN   Name=gag {ECO:0000313|EMBL:ABO61558.1};
OS   Human immunodeficiency virus 1.
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX   NCBI_TaxID=11676 {ECO:0000313|EMBL:ABO61558.1};
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1] {ECO:0000313|EMBL:ABO61558.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=01CEB072 {ECO:0000313|EMBL:ABO61558.1};
RA   Brennan C.A., Brites C., Bodelle P., Golden A., Hackett J.Jr.,
RA   Holzmayer V., Swanson P., Vallari A., Yamaguchi J., Devare S., Pedroso C.,
RA   Ramos A., Badaro R.;
RT   "HIV-1 strains identified in blood donors in Brazil: Significant prevalence
RT   of B/F1 recombinants.";
RL   Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0007829|PDB:2PWO}
RP   X-RAY CRYSTALLOGRAPHY (1.45 ANGSTROMS) OF 33-178.
RX   PubMed=17826792; DOI=10.1016/j.jmb.2007.07.070;
RA   Kelly B.N., Kyere S., Kinde I., Tang C., Howard B.R., Robinson H.,
RA   Sundquist W.I., Summers M.F., Hill C.P.;
RT   "Structure of the antiviral assembly inhibitor CAP-1 complex with the HIV-1
RT   CA protein.";
RL   J. Mol. Biol. 373:355-366(2007).
RN   [3] {ECO:0007829|PDB:4B4N}
RP   X-RAY CRYSTALLOGRAPHY (1.81 ANGSTROMS) OF 33-178.
RX   PubMed=22956906; DOI=10.1371/journal.ppat.1002896;
RA   Price A.J., Fletcher A.J., Schaller T., Elliott T., Lee K.,
RA   KewalRamani V.N., Chin J.W., Towers G.J., James L.C.;
RT   "CPSF6 defines a conserved capsid interface that modulates HIV-1
RT   replication.";
RL   PLoS Pathog. 8:e1002896-e1002896(2012).
RN   [4] {ECO:0007829|PDB:4INB}
RP   X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 33-178.
RX   PubMed=23401268; DOI=10.1002/cmdc.201200580;
RA   Goudreau N., Coulombe R., Faucher A.M., Grand-Maitre C., Lacoste J.E.,
RA   Lemke C.T., Malenfant E., Bousquet Y., Fader L., Simoneau B., Mercier J.F.,
RA   Titolo S., Mason S.W.;
RT   "Monitoring binding of HIV-1 capsid assembly inhibitors using (19)F
RT   ligand- and (15)N protein-based NMR and X-ray crystallography: early hit
RT   validation of a benzodiazepine series.";
RL   ChemMedChem 8:405-414(2013).
RN   [5] {ECO:0007829|PDB:5HGK}
RP   X-RAY CRYSTALLOGRAPHY (1.76 ANGSTROMS) OF 33-178.
RX   PubMed=27509857; DOI=10.1038/nature19098;
RA   Jacques D.A., McEwan W.A., Hilditch L., Price A.J., Towers G.J.,
RA   James L.C.;
RT   "HIV-1 uses dynamic capsid pores to import nucleotides and fuel
RT   encapsidated DNA synthesis.";
RL   Nature 536:349-353(2016).
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000256|ARBA:ARBA00004328}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; EF150408; ABO61558.1; -; Genomic_RNA.
DR   PDB; 2PWO; X-ray; 1.45 A; A/B/C/D=33-178.
DR   PDB; 4B4N; X-ray; 1.81 A; A=33-178.
DR   PDB; 4INB; X-ray; 1.80 A; A=33-178.
DR   PDB; 5HGK; X-ray; 1.76 A; A/B=33-178.
DR   PDBsum; 2PWO; -.
DR   PDBsum; 4B4N; -.
DR   PDBsum; 4INB; -.
DR   PDBsum; 5HGK; -.
DR   SMR; A9PKC6; -.
DR   GO; GO:0019028; C:viral capsid; IEA:UniProtKB-KW.
DR   GO; GO:0016032; P:viral process; IEA:InterPro.
DR   Gene3D; 1.10.1200.30; -; 1.
DR   Gene3D; 1.10.375.10; Human Immunodeficiency Virus Type 1 Capsid Protein; 1.
DR   Gene3D; 1.10.150.90; Immunodeficiency lentiviruses, gag gene matrix protein p17; 1.
DR   Gene3D; 1.20.5.760; Single helix bin; 1.
DR   InterPro; IPR045345; Gag_p24_C.
DR   InterPro; IPR012344; Matrix_HIV/RSV_N.
DR   InterPro; IPR008916; Retrov_capsid_C.
DR   InterPro; IPR008919; Retrov_capsid_N.
DR   PANTHER; PTHR40389; ENDOGENOUS RETROVIRUS GROUP K MEMBER 24 GAG POLYPROTEIN-RELATED; 1.
DR   PANTHER; PTHR40389:SF3; IGE-BINDING PROTEIN; 1.
DR   Pfam; PF00607; Gag_p24; 1.
DR   Pfam; PF19317; Gag_p24_C; 1.
DR   SUPFAM; SSF47353; Retrovirus capsid dimerization domain-like; 1.
DR   SUPFAM; SSF47943; Retrovirus capsid protein, N-terminal core domain; 1.
PE   1: Evidence at protein level;
KW   3D-structure {ECO:0007829|PDB:2PWO, ECO:0007829|PDB:4B4N};
KW   Capsid protein {ECO:0000256|ARBA:ARBA00022561};
KW   Virion {ECO:0000256|ARBA:ARBA00022844}.
FT   DOMAIN          176..249
FT                   /note="Retroviral nucleocapsid Gag protein p24 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF19317"
FT   REGION          1..28
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..15
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:ABO61558.1"
FT   NON_TER         276
FT                   /evidence="ECO:0000313|EMBL:ABO61558.1"
SQ   SEQUENCE   276 AA;  30411 MW;  218A040C26CA6338 CRC64;
     ALDKIEEEQN KSKKKAQQAA DAGNSSQVSQ NYPIVQNLQG QMVHQAISPR TLNAWVKVVE
     EKAFSPEVIP MFSALSEGAT PQDLNTMLNT VGGHQAAMQM LKETINEEAA EWDRLHPVHA
     GPIAPGQMRE PRGSDIAGTT STLQEQIGWM THNPPIPVGE IYKRWIILGL NKIVRMYSPS
     SILDIRQGPK EPFRDYVDRF YKTLRAEQAS QEVKNWMTET LLVQNANPDC KTILKALGPA
     ATLEEMMTAC QGVGGPGHKA RVLAEAMSQV TNSANI
//