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A9PKC6

- A9PKC6_9HIV1

UniProt

A9PKC6 - A9PKC6_9HIV1

Protein
Submitted name:

Gag protein

Gene

gag

Organism
Human immunodeficiency virus 1
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 32 (01 Oct 2014)
      Sequence version 1 (05 Feb 2008)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei160 – 1601Chloride; via amide nitrogenImported

    GO - Biological processi

    1. viral process Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Gag proteinImported
    Gene namesi
    Name:gagImported
    OrganismiHuman immunodeficiency virus 1Imported
    Taxonomic identifieri11676 [NCBI]
    Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusPrimate lentivirus group
    Virus hostiHomo sapiens (Human) [TaxID: 9606]

    Subcellular locationi

    GO - Cellular componenti

    1. viral capsid Source: UniProtKB-KW

    Keywords - Cellular componenti

    Capsid proteinUniRule annotation, Virion

    Pathology & Biotechi

    Keywords - Diseasei

    AIDSUniRule annotation

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2PWOX-ray1.45A/B/C/D33-178[»]
    4B4NX-ray1.81A33-178[»]
    4INBX-ray1.80A33-178[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Family and domain databases

    Gene3Di1.10.1200.30. 1 hit.
    1.10.375.10. 1 hit.
    InterProiIPR000721. Gag_p24.
    IPR008916. Retrov_capsid_C.
    IPR008919. Retrov_capsid_N.
    [Graphical view]
    PfamiPF00607. Gag_p24. 1 hit.
    [Graphical view]
    SUPFAMiSSF47353. SSF47353. 1 hit.
    SSF47943. SSF47943. 1 hit.

    Sequencei

    Sequence statusi: Fragment.

    A9PKC6-1 [UniParc]FASTAAdd to Basket

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    ALDKIEEEQN KSKKKAQQAA DAGNSSQVSQ NYPIVQNLQG QMVHQAISPR    50
    TLNAWVKVVE EKAFSPEVIP MFSALSEGAT PQDLNTMLNT VGGHQAAMQM 100
    LKETINEEAA EWDRLHPVHA GPIAPGQMRE PRGSDIAGTT STLQEQIGWM 150
    THNPPIPVGE IYKRWIILGL NKIVRMYSPS SILDIRQGPK EPFRDYVDRF 200
    YKTLRAEQAS QEVKNWMTET LLVQNANPDC KTILKALGPA ATLEEMMTAC 250
    QGVGGPGHKA RVLAEAMSQV TNSANI 276
    Length:276
    Mass (Da):30,411
    Last modified:February 5, 2008 - v1
    Checksum:i218A040C26CA6338
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported
    Non-terminal residuei276 – 2761Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EF150408 Genomic RNA. Translation: ABO61558.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EF150408 Genomic RNA. Translation: ABO61558.1 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2PWO X-ray 1.45 A/B/C/D 33-178 [» ]
    4B4N X-ray 1.81 A 33-178 [» ]
    4INB X-ray 1.80 A 33-178 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 1.10.1200.30. 1 hit.
    1.10.375.10. 1 hit.
    InterProi IPR000721. Gag_p24.
    IPR008916. Retrov_capsid_C.
    IPR008919. Retrov_capsid_N.
    [Graphical view ]
    Pfami PF00607. Gag_p24. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47353. SSF47353. 1 hit.
    SSF47943. SSF47943. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "HIV-1 strains identified in blood donors in Brazil: Significant prevalence of B/F1 recombinants."
      Brennan C.A., Brites C., Bodelle P., Golden A., Hackett J.Jr., Holzmayer V., Swanson P., Vallari A., Yamaguchi J., Devare S., Pedroso C., Ramos A., Badaro R.
      Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: 01CEB072Imported.
    2. "Structure of the antiviral assembly inhibitor CAP-1 complex with the HIV-1 CA protein."
      Kelly B.N., Kyere S., Kinde I., Tang C., Howard B.R., Robinson H., Sundquist W.I., Summers M.F., Hill C.P.
      J. Mol. Biol. 373:355-366(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.45 ANGSTROMS) OF 33-178.
    3. Cited for: X-RAY CRYSTALLOGRAPHY (1.81 ANGSTROMS) OF 33-178.
    4. "Monitoring binding of HIV-1 capsid assembly inhibitors using (19)F ligand-and (15)N protein-based NMR and X-ray crystallography: early hit validation of a benzodiazepine series."
      Goudreau N., Coulombe R., Faucher A.M., Grand-Maitre C., Lacoste J.E., Lemke C.T., Malenfant E., Bousquet Y., Fader L., Simoneau B., Mercier J.F., Titolo S., Mason S.W.
      ChemMedChem 8:405-414(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 33-178.

    Entry informationi

    Entry nameiA9PKC6_9HIV1
    AccessioniPrimary (citable) accession number: A9PKC6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 5, 2008
    Last sequence update: February 5, 2008
    Last modified: October 1, 2014
    This is version 32 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3