Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A9PKC6

- A9PKC6_9HIV1

UniProt

A9PKC6 - A9PKC6_9HIV1

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Submitted name:

Gag protein

Gene

gag

Organism
Human immunodeficiency virus 1
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei160 – 1601Chloride; via amide nitrogenImported

GO - Biological processi

  1. viral process Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Gag proteinImported
Gene namesi
Name:gagImported
OrganismiHuman immunodeficiency virus 1Imported
Taxonomic identifieri11676 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusPrimate lentivirus group
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Subcellular locationi

GO - Cellular componenti

  1. viral capsid Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Capsid proteinUniRule annotation, Virion

Pathology & Biotechi

Keywords - Diseasei

AIDSUniRule annotation

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2PWOX-ray1.45A/B/C/D33-178[»]
4B4NX-ray1.81A33-178[»]
4INBX-ray1.80A33-178[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Family and domain databases

Gene3Di1.10.1200.30. 1 hit.
1.10.375.10. 1 hit.
InterProiIPR000721. Gag_p24.
IPR008916. Retrov_capsid_C.
IPR008919. Retrov_capsid_N.
[Graphical view]
PfamiPF00607. Gag_p24. 1 hit.
[Graphical view]
SUPFAMiSSF47353. SSF47353. 1 hit.
SSF47943. SSF47943. 1 hit.

Sequencei

Sequence statusi: Fragment.

A9PKC6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
ALDKIEEEQN KSKKKAQQAA DAGNSSQVSQ NYPIVQNLQG QMVHQAISPR
60 70 80 90 100
TLNAWVKVVE EKAFSPEVIP MFSALSEGAT PQDLNTMLNT VGGHQAAMQM
110 120 130 140 150
LKETINEEAA EWDRLHPVHA GPIAPGQMRE PRGSDIAGTT STLQEQIGWM
160 170 180 190 200
THNPPIPVGE IYKRWIILGL NKIVRMYSPS SILDIRQGPK EPFRDYVDRF
210 220 230 240 250
YKTLRAEQAS QEVKNWMTET LLVQNANPDC KTILKALGPA ATLEEMMTAC
260 270
QGVGGPGHKA RVLAEAMSQV TNSANI
Length:276
Mass (Da):30,411
Last modified:February 5, 2008 - v1
Checksum:i218A040C26CA6338
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei276 – 2761Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EF150408 Genomic RNA. Translation: ABO61558.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EF150408 Genomic RNA. Translation: ABO61558.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2PWO X-ray 1.45 A/B/C/D 33-178 [» ]
4B4N X-ray 1.81 A 33-178 [» ]
4INB X-ray 1.80 A 33-178 [» ]
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.10.1200.30. 1 hit.
1.10.375.10. 1 hit.
InterProi IPR000721. Gag_p24.
IPR008916. Retrov_capsid_C.
IPR008919. Retrov_capsid_N.
[Graphical view ]
Pfami PF00607. Gag_p24. 1 hit.
[Graphical view ]
SUPFAMi SSF47353. SSF47353. 1 hit.
SSF47943. SSF47943. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "HIV-1 strains identified in blood donors in Brazil: Significant prevalence of B/F1 recombinants."
    Brennan C.A., Brites C., Bodelle P., Golden A., Hackett J.Jr., Holzmayer V., Swanson P., Vallari A., Yamaguchi J., Devare S., Pedroso C., Ramos A., Badaro R.
    Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 01CEB072Imported.
  2. "Structure of the antiviral assembly inhibitor CAP-1 complex with the HIV-1 CA protein."
    Kelly B.N., Kyere S., Kinde I., Tang C., Howard B.R., Robinson H., Sundquist W.I., Summers M.F., Hill C.P.
    J. Mol. Biol. 373:355-366(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.45 ANGSTROMS) OF 33-178.
  3. Cited for: X-RAY CRYSTALLOGRAPHY (1.81 ANGSTROMS) OF 33-178.
  4. "Monitoring binding of HIV-1 capsid assembly inhibitors using (19)F ligand-and (15)N protein-based NMR and X-ray crystallography: early hit validation of a benzodiazepine series."
    Goudreau N., Coulombe R., Faucher A.M., Grand-Maitre C., Lacoste J.E., Lemke C.T., Malenfant E., Bousquet Y., Fader L., Simoneau B., Mercier J.F., Titolo S., Mason S.W.
    ChemMedChem 8:405-414(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 33-178.

Entry informationi

Entry nameiA9PKC6_9HIV1
AccessioniPrimary (citable) accession number: A9PKC6
Entry historyi
Integrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: October 29, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3