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A9PKC6 (A9PKC6_9HIV1) Unreviewed, UniProtKB/TrEMBL

Last modified December 11, 2013. Version 29. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
Gene names
Name:gag EMBL ABO61558.1
OrganismHuman immunodeficiency virus 1 EMBL ABO61558.1
Taxonomic identifier11676 [NCBI]
Taxonomic lineageVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusPrimate lentivirus group
Virus hostHomo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length276 AA.
Sequence statusFragment.
Protein existenceEvidence at protein level

Ontologies

Keywords
   Cellular componentCapsid protein RuleBase RU000316
Virion
   DiseaseAIDS RuleBase RU004310
   LigandChloride PDB 2PWO
   Technical term3D-structure PDB 4B4N PDB 2PWO PDB 4INB
Gene Ontology (GO)
   Biological_processviral process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentviral capsid

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Binding site1601Chloride; via amide nitrogen PDB 2PWO

Experimental info

Non-terminal residue11 EMBL ABO61558.1
Non-terminal residue2761 EMBL ABO61558.1

Sequences

Sequence LengthMass (Da)Tools
A9PKC6 [UniParc].

Last modified February 5, 2008. Version 1.
Checksum: 218A040C26CA6338

FASTA27630,411
        10         20         30         40         50         60 
ALDKIEEEQN KSKKKAQQAA DAGNSSQVSQ NYPIVQNLQG QMVHQAISPR TLNAWVKVVE 

        70         80         90        100        110        120 
EKAFSPEVIP MFSALSEGAT PQDLNTMLNT VGGHQAAMQM LKETINEEAA EWDRLHPVHA 

       130        140        150        160        170        180 
GPIAPGQMRE PRGSDIAGTT STLQEQIGWM THNPPIPVGE IYKRWIILGL NKIVRMYSPS 

       190        200        210        220        230        240 
SILDIRQGPK EPFRDYVDRF YKTLRAEQAS QEVKNWMTET LLVQNANPDC KTILKALGPA 

       250        260        270 
ATLEEMMTAC QGVGGPGHKA RVLAEAMSQV TNSANI 

« Hide

References

[1]"HIV-1 strains identified in blood donors in Brazil: Significant prevalence of B/F1 recombinants."
Brennan C.A., Brites C., Bodelle P., Golden A., Hackett J.Jr., Holzmayer V., Swanson P., Vallari A., Yamaguchi J., Devare S., Pedroso C., Ramos A., Badaro R.
Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: 01CEB072 EMBL ABO61558.1.
[2]"Structure of the antiviral assembly inhibitor CAP-1 complex with the HIV-1 CA protein."
Kelly B.N., Kyere S., Kinde I., Tang C., Howard B.R., Robinson H., Sundquist W.I., Summers M.F., Hill C.P.
J. Mol. Biol. 373:355-366(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.45 ANGSTROMS) OF 33-178 IN COMPLEX WITH CHLORIDE.
[3]"CPSF6 defines a conserved capsid interface that modulates HIV-1 replication."
Price A.J., Fletcher A.J., Schaller T., Elliott T., Lee K., KewalRamani V.N., Chin J.W., Towers G.J., James L.C.
PLoS Pathog. 8:e1002896-e1002896(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.81 ANGSTROMS) OF 33-178.
[4]"Monitoring binding of HIV-1 capsid assembly inhibitors using (19)F ligand-and (15)N protein-based NMR and X-ray crystallography: early hit validation of a benzodiazepine series."
Goudreau N., Coulombe R., Faucher A.M., Grand-Maitre C., Lacoste J.E., Lemke C.T., Malenfant E., Bousquet Y., Fader L., Simoneau B., Mercier J.F., Titolo S., Mason S.W.
ChemMedChem 8:405-414(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 33-178.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
EF150408 Genomic RNA. Translation: ABO61558.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2PWOX-ray1.45A/B/C/D33-178[»]
4B4NX-ray1.81A33-178[»]
4INBX-ray1.80A33-178[»]
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.10.1200.30. 1 hit.
1.10.375.10. 1 hit.
InterProIPR000721. Gag_p24.
IPR008916. Retrov_capsid_C.
IPR008919. Retrov_capsid_N.
[Graphical view]
PfamPF00607. Gag_p24. 1 hit.
[Graphical view]
SUPFAMSSF47353. SSF47353. 1 hit.
SSF47943. SSF47943. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA9PKC6_9HIV1
AccessionPrimary (citable) accession number: A9PKC6
Entry history
Integrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: December 11, 2013
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)