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Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Acholeplasma laidlawii (strain PG-8A)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathwayi: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (pgi)
  3. ATP-dependent 6-phosphofructokinase (pfk1), Pyrophosphate--fructose 6-phosphate 1-phosphotransferase (pfk2)
  4. no protein annotated in this organism
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei279Proton donorUniRule annotation1
Active sitei300UniRule annotation1
Active sitei413UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processGluconeogenesis, Glycolysis

Enzyme and pathway databases

BioCyciALAI441768:G1GAM-1379-MONOMER
UniPathwayiUPA00109; UER00181
UPA00138

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation)
Short name:
GPIUniRule annotation
Alternative name(s):
Phosphoglucose isomeraseUniRule annotation
Short name:
PGIUniRule annotation
Phosphohexose isomeraseUniRule annotation
Short name:
PHIUniRule annotation
Gene namesi
Name:pgiUniRule annotation
Ordered Locus Names:ACL_1358
OrganismiAcholeplasma laidlawii (strain PG-8A)
Taxonomic identifieri441768 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesAcholeplasmatalesAcholeplasmataceaeAcholeplasma
Proteomesi
  • UP000008558 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000812291 – 423Glucose-6-phosphate isomeraseAdd BLAST423

Interactioni

Protein-protein interaction databases

STRINGi441768.ACL_1358

Structurei

3D structure databases

ProteinModelPortaliA9NHX0
SMRiA9NHX0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QYV Bacteria
COG0166 LUCA
HOGENOMiHOG000100403
KOiK01810
OMAiSFIIPDD
OrthoDBiPOG091H0EIM

Family and domain databases

CDDicd05015 SIS_PGI_1, 1 hit
cd05016 SIS_PGI_2, 1 hit
HAMAPiMF_00473 G6P_isomerase, 1 hit
InterProiView protein in InterPro
IPR001672 G6P_Isomerase
IPR018189 Phosphoglucose_isomerase_CS
IPR035476 SIS_PGI_1
IPR035482 SIS_PGI_2
PANTHERiPTHR11469 PTHR11469, 1 hit
PfamiView protein in Pfam
PF00342 PGI, 1 hit
PRINTSiPR00662 G6PISOMERASE
PROSITEiView protein in PROSITE
PS00765 P_GLUCOSE_ISOMERASE_1, 1 hit
PS00174 P_GLUCOSE_ISOMERASE_2, 1 hit
PS51463 P_GLUCOSE_ISOMERASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

A9NHX0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKLDIKDAK KFLKTNVFSL QDQVNELHDV IQNKSGLGND FLGWLDLPLT
60 70 80 90 100
YDKEELDRIY KLKEQHKNVD AIVVIGIGGS YLGAKAGYEF LKTPFKKQKP
110 120 130 140 150
ELIFAGHHLS ANYLKHLLKY LNKKNYVINV ISKSGTTTEP AVAFRLLKAH
160 170 180 190 200
IENKYGVKEA RKRIFATTDK ARGSLYQLAI NEGYERFVIE DNVGGRFSVL
210 220 230 240 250
SAVGLLPFVF VGIDVEKMIK GAQDAYHDAQ DPSLKKNKAY LYAVTRFLLN
260 270 280 290 300
QSGKDVEYLI NYEPRLAFFA EWWKQLFGES EGKGGKGLLV HSASFTTDLH
310 320 330 340 350
SLGQQIQDGN RIIFETVLNV KKTDKLSIPF VEEDLDKLNY IAGKEISYVN
360 370 380 390 400
EQAFLGTKEA HIDGGVPNIV ITIDKMDAYH FGYLVYFFEI ACAMSAYLLE
410 420
VNPFDQPGVE AYKKNMFRLL GKK
Length:423
Mass (Da):47,924
Last modified:February 5, 2008 - v1
Checksum:i9BF7BB9E277CC5CC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000896 Genomic DNA Translation: ABX81950.1
RefSeqiWP_012243281.1, NC_010163.1

Genome annotation databases

EnsemblBacteriaiABX81950; ABX81950; ACL_1358
KEGGiacl:ACL_1358

Similar proteinsi

Entry informationi

Entry nameiG6PI_ACHLI
AccessioniPrimary (citable) accession number: A9NHX0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: February 28, 2018
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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