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Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Acholeplasma laidlawii (strain PG-8A)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei279 – 2791Proton donorUniRule annotation
Active sitei300 – 3001UniRule annotation
Active sitei413 – 4131UniRule annotation

GO - Molecular functioni

  1. glucose-6-phosphate isomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-HAMAP
  2. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

BioCyciALAI441768:GI40-1358-MONOMER.
UniPathwayiUPA00109; UER00181.
UPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation)
Short name:
GPIUniRule annotation
Alternative name(s):
Phosphoglucose isomeraseUniRule annotation
Short name:
PGIUniRule annotation
Phosphohexose isomeraseUniRule annotation
Short name:
PHIUniRule annotation
Gene namesi
Name:pgiUniRule annotation
Ordered Locus Names:ACL_1358
OrganismiAcholeplasma laidlawii (strain PG-8A)
Taxonomic identifieri441768 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesAcholeplasmatalesAcholeplasmataceaeAcholeplasma
ProteomesiUP000008558 Componenti: Chromosome

Subcellular locationi

  1. Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 423423Glucose-6-phosphate isomerasePRO_1000081229Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi441768.ACL_1358.

Structurei

3D structure databases

ProteinModelPortaliA9NHX0.
SMRiA9NHX0. Positions 2-423.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0166.
HOGENOMiHOG000100403.
KOiK01810.
OMAiVDWTERT.
OrthoDBiEOG64R61J.

Family and domain databases

HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9NHX0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKLDIKDAK KFLKTNVFSL QDQVNELHDV IQNKSGLGND FLGWLDLPLT
60 70 80 90 100
YDKEELDRIY KLKEQHKNVD AIVVIGIGGS YLGAKAGYEF LKTPFKKQKP
110 120 130 140 150
ELIFAGHHLS ANYLKHLLKY LNKKNYVINV ISKSGTTTEP AVAFRLLKAH
160 170 180 190 200
IENKYGVKEA RKRIFATTDK ARGSLYQLAI NEGYERFVIE DNVGGRFSVL
210 220 230 240 250
SAVGLLPFVF VGIDVEKMIK GAQDAYHDAQ DPSLKKNKAY LYAVTRFLLN
260 270 280 290 300
QSGKDVEYLI NYEPRLAFFA EWWKQLFGES EGKGGKGLLV HSASFTTDLH
310 320 330 340 350
SLGQQIQDGN RIIFETVLNV KKTDKLSIPF VEEDLDKLNY IAGKEISYVN
360 370 380 390 400
EQAFLGTKEA HIDGGVPNIV ITIDKMDAYH FGYLVYFFEI ACAMSAYLLE
410 420
VNPFDQPGVE AYKKNMFRLL GKK
Length:423
Mass (Da):47,924
Last modified:February 5, 2008 - v1
Checksum:i9BF7BB9E277CC5CC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000896 Genomic DNA. Translation: ABX81950.1.
RefSeqiYP_001621326.1. NC_010163.1.

Genome annotation databases

EnsemblBacteriaiABX81950; ABX81950; ACL_1358.
KEGGiacl:ACL_1358.
PATRICi20639406. VBIAchLai134690_1303.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000896 Genomic DNA. Translation: ABX81950.1.
RefSeqiYP_001621326.1. NC_010163.1.

3D structure databases

ProteinModelPortaliA9NHX0.
SMRiA9NHX0. Positions 2-423.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi441768.ACL_1358.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABX81950; ABX81950; ACL_1358.
KEGGiacl:ACL_1358.
PATRICi20639406. VBIAchLai134690_1303.

Phylogenomic databases

eggNOGiCOG0166.
HOGENOMiHOG000100403.
KOiK01810.
OMAiVDWTERT.
OrthoDBiEOG64R61J.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.
UPA00138.
BioCyciALAI441768:GI40-1358-MONOMER.

Family and domain databases

HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PG-8A.

Entry informationi

Entry nameiG6PI_ACHLI
AccessioniPrimary (citable) accession number: A9NHX0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: April 29, 2015
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.