Reviewed, UniProtKB/Swiss-Prot A9NHX0 (G6PI_ACHLI)

Names and origin

Protein names

Recommended name:
    Glucose-6-phosphate isomerase
      Short name=GPI
    EC=5.3.1.9
Alternative name(s):
    Phosphoglucose isomerase
      Short name=PGI
    Phosphohexose isomerase
      Short name=PHI

Gene names

Name:	pgi
Ordered Locus Names:	ACL_1358

Organism

Acholeplasma laidlawii (strain PG-8A) [Complete proteome] [HAMAP]

Taxonomic identifier

441768 [NCBI]

Taxonomic lineage

Bacteria › Tenericutes › Mollicutes › Acholeplasmatales › Acholeplasmataceae › Acholeplasma

Protein attributes

Sequence length	423 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP MF_00473
Pathway	Carbohydrate biosynthesis; gluconeogenesis. HAMAP MF_00473 Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP MF_00473
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the GPI family.

Ontologies

Keywords
Biological process	Gluconeogenesis Glycolysis
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from electronic annotation. Source: HAMAP glycolysis Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucose-6-phosphate isomerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 423	423	Glucose-6-phosphate isomerase HAMAP MF_00473		PRO_1000081229
Sites
	Active site	279	1	Proton donor By similarity
	Active site	300	1	By similarity
	Active site	413	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	A9NHX0-1 [UniParc]. Last modified February 5, 2008. Version 1. Checksum: 9BF7BB9E277CC5CC	FASTA	423	47,924
	10 20 30 40 50 60 MIKLDIKDAK KFLKTNVFSL QDQVNELHDV IQNKSGLGND FLGWLDLPLT YDKEELDRIY 70 80 90 100 110 120 KLKEQHKNVD AIVVIGIGGS YLGAKAGYEF LKTPFKKQKP ELIFAGHHLS ANYLKHLLKY 130 140 150 160 170 180 LNKKNYVINV ISKSGTTTEP AVAFRLLKAH IENKYGVKEA RKRIFATTDK ARGSLYQLAI 190 200 210 220 230 240 NEGYERFVIE DNVGGRFSVL SAVGLLPFVF VGIDVEKMIK GAQDAYHDAQ DPSLKKNKAY 250 260 270 280 290 300 LYAVTRFLLN QSGKDVEYLI NYEPRLAFFA EWWKQLFGES EGKGGKGLLV HSASFTTDLH 310 320 330 340 350 360 SLGQQIQDGN RIIFETVLNV KKTDKLSIPF VEEDLDKLNY IAGKEISYVN EQAFLGTKEA 370 380 390 400 410 420 HIDGGVPNIV ITIDKMDAYH FGYLVYFFEI ACAMSAYLLE VNPFDQPGVE AYKKNMFRLL GKK

References

[1]

"Acholeplasma laidlawii complete genome." Kovaleva G.Y., Kazanov M.D., Malko D.B., Vitreschak A.G., Sernova N.V., Gelfand M.S., Lazarev V.N., Levitskii S.A., Basovskii Y.I., Chukin M.M., Akopian T.A., Vereshchagin V.A., Kostrjukova E.S., Selezneva O.V., Vtyurin N.N., Rogov S.I., Alekseev D.G., Ladygina V.G. , Titova G.A., Karpov V.A., Govorun V.M. Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000896 Genomic DNA. Translation: ABX81950.1.
RefSeq	YP_001621326.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5804060.
GenomeReviews	Gene locus ACL_1358 in contig CP000896_GR.
KEGG	acl:ACL_1358.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	NPRKNVI.
Family and domain databases
HAMAP	MF_00473. [Tree]
InterPro	IPR001672. G6P_Isomerase. IPR018189. Phosphoglucose_isomerase_CS. [Graphical view]
PANTHER	PTHR11469. G6P_Isomerase. 1 hit.
Pfam	PF00342. PGI. 1 hit. [Graphical view]
PRINTS	PR00662. G6PISOMERASE.
PROSITE	PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit. PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit. PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PI_ACHLI

Accession

Primary (citable) accession number: A9NHX0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	February 5, 2008
Last modified:	November 3, 2009
This is version 14 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)