Reviewed, UniProtKB/Swiss-Prot A9NHH8 (PGK_ACHLI)

Names and origin

Protein names

Recommended name:
    Phosphoglycerate kinase
    EC=2.7.2.3

Gene names

Name:	pgk
Ordered Locus Names:	ACL_1209

Organism

Acholeplasma laidlawii (strain PG-8A) [Complete proteome] [HAMAP]

Taxonomic identifier

441768 [NCBI]

Taxonomic lineage

Bacteria › Tenericutes › Mollicutes › Acholeplasmatales › Acholeplasmataceae › Acholeplasma

Protein attributes

Sequence length	399 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. HAMAP MF_00145
Pathway	Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5. HAMAP MF_00145
Subunit structure	Monomer By similarity. HAMAP MF_00145
Subcellular location	Cytoplasm Potential HAMAP MF_00145.
Sequence similarities	Belongs to the phosphoglycerate kinase family.

Ontologies

Keywords
Biological process	Glycolysis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycolysis Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoglycerate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 399	399	Phosphoglycerate kinase HAMAP MF_00145		PRO_1000076578
Regions
	Nucleotide binding	355 – 358	4	ATP By similarity
	Region	21 – 23	3	Substrate binding By similarity
	Region	60 – 63	4	Substrate binding By similarity
Sites
	Binding site	37	1	Substrate By similarity
	Binding site	120	1	Substrate By similarity
	Binding site	157	1	Substrate By similarity
	Binding site	208	1	ATP By similarity
	Binding site	296	1	ATP; via carbonyl oxygen By similarity
	Binding site	327	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	A9NHH8-1 [UniParc]. Last modified February 5, 2008. Version 1. Checksum: 437BA8B2468A40D6	FASTA	399	42,767
	10 20 30 40 50 60 MAKKTIRDIE LKNKSVLMRV DFNVPLNKDG SISDDTRITA ALPTIEYAIE KGAKLILFSH 70 80 90 100 110 120 LGRIKTAEDK ATNSLKPVAA RLSELIGRPV VFIPETRGEA LEAAVKNLKS GDVLMFENTR 130 140 150 160 170 180 FEDLDGNKES KNNPELGKYW ASLGDVFVND AFGTAHRAHA SNVGIANNME VSVAGLLLEK 190 200 210 220 230 240 EINFIGGALE NPERPFVAIL GGAKVSDKIE VIKNLLKVAD KVLIGGGMAF TFLKAQGFEV 250 260 270 280 290 300 GKSLVELDKL DLAKELLELS KGKIELGFDV VTGKAFDKDT ETNVRSFDAI PADEMGLDIG 310 320 330 340 350 360 PKTVARFKEI IASAKTVVWN GPQGVFEMEK FANGTLEVTK ALADLHGKAI TIVGGGDSAA 370 380 390 AVAKFGLEDK FSHISTGGGA SLEYLEGKVL PGVELVDVI

References

[1]

"Acholeplasma laidlawii complete genome." Kovaleva G.Y., Kazanov M.D., Malko D.B., Vitreschak A.G., Sernova N.V., Gelfand M.S., Lazarev V.N., Levitskii S.A., Basovskii Y.I., Chukin M.M., Akopian T.A., Vereshchagin V.A., Kostrjukova E.S., Selezneva O.V., Vtyurin N.N., Rogov S.I., Alekseev D.G., Ladygina V.G. , Titova G.A., Karpov V.A., Govorun V.M. Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000896 Genomic DNA. Translation: ABX81808.1.
RefSeq	YP_001621184.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5803962.
GenomeReviews	Gene locus ACL_1209 in contig CP000896_GR.
KEGG	acl:ACL_1209.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG453500.
OMA	GEKDNMS.
Family and domain databases
HAMAP	MF_00145. Phosphoglyc_kinase. [Tree]
InterPro	IPR001576. Phosphoglycerate_kinase. IPR015901. Phosphoglycerate_kinase_C. IPR015824. Phosphoglycerate_kinase_N. [Graphical view]
Gene3D	G3DSA:3.40.50.1270. Phosphoglycerate_kinase_C. 1 hit. G3DSA:3.40.50.1260. Phosphoglycerate_kinase_N. 1 hit.
PANTHER	PTHR11406. PGK. 1 hit.
Pfam	PF00162. PGK. 1 hit. [Graphical view]
PRINTS	PR00477. PHGLYCKINASE.
PROSITE	PS00111. PGLYCERATE_KINASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PGK_ACHLI

Accession

Primary (citable) accession number: A9NHH8

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	February 5, 2008
Last modified:	January 19, 2010
This is version 17 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)