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A9NGE2

- PNP_ACHLI

UniProt

A9NGE2 - PNP_ACHLI

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Protein
Polyribonucleotide nucleotidyltransferase
Gene
pnp, ACL_0808
Organism
Acholeplasma laidlawii (strain PG-8A)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction By similarity.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi500 – 5001Magnesium By similarity
Metal bindingi506 – 5061Magnesium By similarity

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. RNA binding Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. RNA processing Source: InterPro
  2. mRNA catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciALAI441768:GI40-808-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferase (EC:2.7.7.8)
Alternative name(s):
Polynucleotide phosphorylase
Short name:
PNPase
Gene namesi
Name:pnp
Ordered Locus Names:ACL_0808
OrganismiAcholeplasma laidlawii (strain PG-8A)
Taxonomic identifieri441768 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesAcholeplasmatalesAcholeplasmataceaeAcholeplasma
ProteomesiUP000008558: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 715715Polyribonucleotide nucleotidyltransferaseUniRule annotation
PRO_0000329476Add
BLAST

Proteomic databases

PRIDEiA9NGE2.

Interactioni

Protein-protein interaction databases

STRINGi441768.ACL_0808.

Structurei

3D structure databases

ProteinModelPortaliA9NGE2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini567 – 63468KH
Add
BLAST
Domaini637 – 71276S1 motif
Add
BLAST

Sequence similaritiesi

Contains 1 KH domain.
Contains 1 S1 motif domain.

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiPRWDWVA.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9NGE2-1 [UniParc]FASTAAdd to Basket

« Hide

MSKQVFETTL AGKPLRVEVG EIAKQANGAA MIYYGDTVVL STAVAKAKVG    50
QTDFFPLMVI YAEKQYAAGK IPGGFFRREG RPSEVETLTS RLIDRPLRPL 100
FDDGYRNEVQ VVNTVLSSDP EASSQMAAML GSSIALEISN IPFMGPIAGA 150
HVGRIDGQFV LNPSSEQLNV SDIDLIVAGT KDAINMVEAG AKQVSEEVML 200
EAILFGHEAI KELCAFQETI KKAFGVEKVE PELLSLNQAI FDEVFAYKGK 250
ELVKAVSLVD KQERYDVIDA IKDEVVAHFE QRNFWMTVDG KEVLDADQKK 300
ELMNQVKVSL DRIVTKEVRR LITEDKVRPD GRGLDEIRPL ASSVDLLPRT 350
HGSALFTRGQ TQALGIVTLG SLNENQIIDG LEQETVTKRF MLHYNFPPFS 400
VGETGRYGAP GRREIGHGAL GERALLQVLP SEDEFPYAIR VVSEITESNG 450
SSSQATICVG SMALMAAGVP IKAPVAGIAM GLIMDGEHYS ILSDIQGMED 500
HEGDMDFKVA GTKDGITALQ MDIKIQGITT EIMKEALEQA RKGRLHILSH 550
MNTVISETRT ELSAFAPKVK MIRINPDKIR DVIGAGGKII TQIIEDHNNV 600
KIDIEQDGRV FIMHTDSAWL NKTAAYIESL VREAKVGELY EAKVTRLLMD 650
KDGKKIQGVF AEIFPGTEGL VHISKWEKER TESLDGKVKV GDQILVKVVK 700
IDERGRVDLS RKDAL 715
Length:715
Mass (Da):78,666
Last modified:February 5, 2008 - v1
Checksum:i0A03C34B64B5E270
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000896 Genomic DNA. Translation: ABX81422.1.
RefSeqiWP_012242753.1. NC_010163.1.
YP_001620798.1. NC_010163.1.

Genome annotation databases

EnsemblBacteriaiABX81422; ABX81422; ACL_0808.
GeneIDi5803780.
KEGGiacl:ACL_0808.
PATRICi20638330. VBIAchLai134690_0784.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000896 Genomic DNA. Translation: ABX81422.1 .
RefSeqi WP_012242753.1. NC_010163.1.
YP_001620798.1. NC_010163.1.

3D structure databases

ProteinModelPortali A9NGE2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 441768.ACL_0808.

Proteomic databases

PRIDEi A9NGE2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABX81422 ; ABX81422 ; ACL_0808 .
GeneIDi 5803780.
KEGGi acl:ACL_0808.
PATRICi 20638330. VBIAchLai134690_0784.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218326.
KOi K00962.
OMAi PRWDWVA.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci ALAI441768:GI40-808-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
PROSITEi PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PG-8A.

Entry informationi

Entry nameiPNP_ACHLI
AccessioniPrimary (citable) accession number: A9NGE2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: February 5, 2008
Last modified: September 3, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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