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A9NG27

- TYSY_ACHLI

UniProt

A9NG27 - TYSY_ACHLI

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Protein

Thymidylate synthase

Gene

thyA

Organism
Acholeplasma laidlawii (strain PG-8A)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Provides the sole de novo source of dTMP for DNA biosynthesis.UniRule annotation

Catalytic activityi

5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei170 – 1701UniRule annotation

GO - Molecular functioni

  1. thymidylate synthase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. dTMP biosynthetic process Source: UniProtKB-HAMAP
  2. dTTP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Nucleotide biosynthesis

Enzyme and pathway databases

BioCyciALAI441768:GI40-691-MONOMER.
UniPathwayiUPA00575.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidylate synthaseUniRule annotation (EC:2.1.1.45UniRule annotation)
Short name:
TSUniRule annotation
Short name:
TSaseUniRule annotation
Gene namesi
Name:thyAUniRule annotation
Ordered Locus Names:ACL_0691
OrganismiAcholeplasma laidlawii (strain PG-8A)
Taxonomic identifieri441768 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesAcholeplasmatalesAcholeplasmataceaeAcholeplasma
ProteomesiUP000008558: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 288288Thymidylate synthasePRO_1000073866Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi441768.ACL_0691.

Structurei

3D structure databases

ProteinModelPortaliA9NG27.
SMRiA9NG27. Positions 2-288.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0207.
HOGENOMiHOG000257899.
KOiK00560.
OMAiDVHLYSN.
OrthoDBiEOG6K6V53.

Family and domain databases

Gene3Di3.30.572.10. 1 hit.
HAMAPiMF_00008. Thymidy_synth_bact.
InterProiIPR023451. Thymidate_synth/dCMP_Mease.
IPR000398. Thymidylate_synthase.
IPR020940. Thymidylate_synthase_AS.
[Graphical view]
PfamiPF00303. Thymidylat_synt. 1 hit.
[Graphical view]
PRINTSiPR00108. THYMDSNTHASE.
SUPFAMiSSF55831. SSF55831. 1 hit.
TIGRFAMsiTIGR03284. thym_sym. 1 hit.
PROSITEiPS00091. THYMIDYLATE_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9NG27-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKQYLDLARH IMENGTLKSD RTGTGTKSIF GYQMFFDLKD GFPLLTTKKT
60 70 80 90 100
FLKGIIHELL WFIKGDTNIK YLVDNNVGIW TDWPYKNYMN SSEYQGESIK
110 120 130 140 150
EFSDKIRQSD EFAKKWGDLG PVYGSQWRNF NGVDQIEYII NTLKTNPDSR
160 170 180 190 200
RMVLSAWNPA EIGQMMLPPC HTLIQFYVVD NKLSLQLYQR SGDVFLGIPF
210 220 230 240 250
NIASYAVFLM MVAQVTGFEL GSFVHTIGDA HIYTNHFDQI NLQLTRTPRR
260 270 280
LPILKINKSI TRLEDFKYED FELVGYDPYP PIKGVVAV
Length:288
Mass (Da):33,318
Last modified:February 5, 2008 - v1
Checksum:iCB8ED04137354174
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000896 Genomic DNA. Translation: ABX81307.1.
RefSeqiYP_001620683.1. NC_010163.1.

Genome annotation databases

EnsemblBacteriaiABX81307; ABX81307; ACL_0691.
GeneIDi5804116.
KEGGiacl:ACL_0691.
PATRICi20638102. VBIAchLai134690_0671.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000896 Genomic DNA. Translation: ABX81307.1 .
RefSeqi YP_001620683.1. NC_010163.1.

3D structure databases

ProteinModelPortali A9NG27.
SMRi A9NG27. Positions 2-288.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 441768.ACL_0691.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABX81307 ; ABX81307 ; ACL_0691 .
GeneIDi 5804116.
KEGGi acl:ACL_0691.
PATRICi 20638102. VBIAchLai134690_0671.

Phylogenomic databases

eggNOGi COG0207.
HOGENOMi HOG000257899.
KOi K00560.
OMAi DVHLYSN.
OrthoDBi EOG6K6V53.

Enzyme and pathway databases

UniPathwayi UPA00575 .
BioCyci ALAI441768:GI40-691-MONOMER.

Family and domain databases

Gene3Di 3.30.572.10. 1 hit.
HAMAPi MF_00008. Thymidy_synth_bact.
InterProi IPR023451. Thymidate_synth/dCMP_Mease.
IPR000398. Thymidylate_synthase.
IPR020940. Thymidylate_synthase_AS.
[Graphical view ]
Pfami PF00303. Thymidylat_synt. 1 hit.
[Graphical view ]
PRINTSi PR00108. THYMDSNTHASE.
SUPFAMi SSF55831. SSF55831. 1 hit.
TIGRFAMsi TIGR03284. thym_sym. 1 hit.
PROSITEi PS00091. THYMIDYLATE_SYNTHASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PG-8A.

Entry informationi

Entry nameiTYSY_ACHLI
AccessioniPrimary (citable) accession number: A9NG27
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: October 29, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3