A9NFI4 (ACKA_ACHLI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetate kinase
EC=2.7.2.1

Alternative name(s):
Acetokinase

Gene names

Name:	ackA
Ordered Locus Names:	ACL_0496

Organism

Acholeplasma laidlawii (strain PG-8A) [Complete proteome] [HAMAP]

Taxonomic identifier

441768 [NCBI]

Taxonomic lineage

Bacteria › Tenericutes › Mollicutes › Acholeplasmatales › Acholeplasmataceae › Acholeplasma

Protein attributes

Sequence length	393 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + acetate = ADP + acetyl phosphate. HAMAP MF_00020 ATP + propanoate = ADP + propanoyl phosphate. HAMAP MF_00020
Pathway	Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2. HAMAP MF_00020
Subcellular location	Cytoplasm By similarity HAMAP MF_00020.
Sequence similarities	Belongs to the acetokinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	organic acid metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 393	393	Acetate kinase HAMAP MF_00020		PRO_1000074180

Sequences

	Sequence		Length	Mass (Da)
	A9NFI4 [UniParc]. Last modified February 5, 2008. Version 1. Checksum: 5EADCC3DA44C13A5	FASTA	393	42,933
	10 20 30 40 50 60 MKILSVNAGS SSLKFQLLQM PEEFEIASGL VERIGNKNAE FKIKFNGSSK TQSDLVVLDH 70 80 90 100 110 120 SVAVDLVIKG LLENKVIASL DEIQGVGHRV VQGGQLFKES VVIDDDVVIK IASLNDLAPL 130 140 150 160 170 180 HNPANIIGIN AFRKAISNVI HVAVFDTTFH QTMPEENFLY GTPYEWYTKH GVRKYGFHGT 190 200 210 220 230 240 SHQYVSELAH ARLGKDHSRI IVAHIGNGAS ITAVRDGKSI DTSMGLTPLE GFPTGTRSGN 250 260 270 280 290 300 VDPAIFQLMQ QKEGYSLEKT LNELNKNSGY LGISGVSHDS RDIIAAAEGG NKRAQLALDI 310 320 330 340 350 360 QAKRIVDYIA SYYVLLGGLD ALVFTAGIGE NAKEVRKLIC DRLGVLGIKL DDNKNNSRGD 370 380 390 KEISSDASNV KIWVIPTNEE VMIARDVLRL QNK

References

[1]

"Complete genome and proteome of Acholeplasma laidlawii." Lazarev V.N., Levitskii S.A., Basovskii Y.I., Chukin M.M., Akopian T.A., Vereshchagin V.V., Kostrjukova E.S., Kovaleva G.Y., Kazanov M.D., Malko D.B., Vitreschak A.G., Sernova N.V., Gelfand M.S., Demina I.A., Serebryakova M.V., Galyamina M.A., Vtyurin N.N., Rogov S.I. , Alexeev D.G., Ladygina V.G., Govorun V.M. J. Bacteriol. 193:4943-4953(2011) [PubMed: 21784942] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PG-8A.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000896 Genomic DNA. Translation: ABX81114.1.
RefSeq	YP_001620490.1. NC_010163.1.
3D structure databases
ProteinModelPortal	A9NFI4.
ModBase	Search...
Protein-protein interaction databases
STRING	A9NFI4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5803765.
GenomeReviews	Gene locus ACL_0496 in contig CP000896_GR.
KEGG	acl:ACL_0496.
PATRIC	20637714. VBIAchLai134690_0477.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG285863.
OMA	MIAREVV.
ProtClustDB	PRK00180.
Enzyme and pathway databases
BioCyc	ALAI441768:ACL_0496-MONOMER.
Family and domain databases
HAMAP	MF_00020. Acetate_kinase. [Tree]
InterPro	IPR004372. Ac/Proprionate_kinase. IPR000890. Aliphatic_acid_kin_short-chain. IPR023865. Aliphatic_acid_kinase_CS. [Graphical view]
KO	K00925.
PANTHER	PTHR21060. Acetate_kin. 1 hit.
Pfam	PF00871. Acetate_kinase. 1 hit. [Graphical view]
PIRSF	PIRSF000722. Acetate_prop_kin. 1 hit.
PRINTS	PR00471. ACETATEKNASE.
TIGRFAMs	TIGR00016. AckA. 1 hit.
PROSITE	PS01075. ACETATE_KINASE_1. 1 hit. PS01076. ACETATE_KINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACKA_ACHLI

Accession

Primary (citable) accession number: A9NFI4

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	February 5, 2008
Last modified:	January 25, 2012
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program