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Protein

Acetate kinase

Gene

ackA

Organism
Acholeplasma laidlawii (strain PG-8A)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.UniRule annotation

Catalytic activityi

ATP + acetate = ADP + acetyl phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Mg2+. Can also accept Mn2+.UniRule annotation

Pathwayi: acetyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes acetyl-CoA from acetate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Acetate kinase (ackA)
  2. no protein annotated in this organism
This subpathway is part of the pathway acetyl-CoA biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetyl-CoA from acetate, the pathway acetyl-CoA biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi7MagnesiumUniRule annotation1
Binding sitei14ATPUniRule annotation1
Binding sitei89SubstrateUniRule annotation1
Active sitei146Proton donor/acceptorUniRule annotation1
Sitei178Transition state stabilizerUniRule annotation1
Sitei237Transition state stabilizerUniRule annotation1
Metal bindingi379MagnesiumUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi204 – 208ATPUniRule annotation5
Nucleotide bindingi279 – 281ATPUniRule annotation3
Nucleotide bindingi327 – 331ATPUniRule annotation5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00340; UER00458.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetate kinaseUniRule annotation (EC:2.7.2.1UniRule annotation)
Alternative name(s):
AcetokinaseUniRule annotation
Gene namesi
Name:ackAUniRule annotation
Ordered Locus Names:ACL_0496
OrganismiAcholeplasma laidlawii (strain PG-8A)
Taxonomic identifieri441768 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesAcholeplasmatalesAcholeplasmataceaeAcholeplasma
Proteomesi
  • UP000008558 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000741801 – 393Acetate kinaseAdd BLAST393

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi441768.ACL_0496.

Structurei

3D structure databases

ProteinModelPortaliA9NFI4.
SMRiA9NFI4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetokinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C6H. Bacteria.
COG0282. LUCA.
HOGENOMiHOG000288398.
KOiK00925.
OMAiWKALTGT.
OrthoDBiPOG091H02K4.

Family and domain databases

HAMAPiMF_00020. Acetate_kinase. 1 hit.
InterProiView protein in InterPro
IPR004372. Ac/propionate_kinase.
IPR000890. Aliphatic_acid_kin_short-chain.
IPR023865. Aliphatic_acid_kinase_CS.
PANTHERiPTHR21060. PTHR21060. 1 hit.
PfamiView protein in Pfam
PF00871. Acetate_kinase. 1 hit.
PIRSFiPIRSF000722. Acetate_prop_kin. 1 hit.
PRINTSiPR00471. ACETATEKNASE.
TIGRFAMsiTIGR00016. ackA. 1 hit.
PROSITEiView protein in PROSITE
PS01075. ACETATE_KINASE_1. 1 hit.
PS01076. ACETATE_KINASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

A9NFI4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKILSVNAGS SSLKFQLLQM PEEFEIASGL VERIGNKNAE FKIKFNGSSK
60 70 80 90 100
TQSDLVVLDH SVAVDLVIKG LLENKVIASL DEIQGVGHRV VQGGQLFKES
110 120 130 140 150
VVIDDDVVIK IASLNDLAPL HNPANIIGIN AFRKAISNVI HVAVFDTTFH
160 170 180 190 200
QTMPEENFLY GTPYEWYTKH GVRKYGFHGT SHQYVSELAH ARLGKDHSRI
210 220 230 240 250
IVAHIGNGAS ITAVRDGKSI DTSMGLTPLE GFPTGTRSGN VDPAIFQLMQ
260 270 280 290 300
QKEGYSLEKT LNELNKNSGY LGISGVSHDS RDIIAAAEGG NKRAQLALDI
310 320 330 340 350
QAKRIVDYIA SYYVLLGGLD ALVFTAGIGE NAKEVRKLIC DRLGVLGIKL
360 370 380 390
DDNKNNSRGD KEISSDASNV KIWVIPTNEE VMIARDVLRL QNK
Length:393
Mass (Da):42,933
Last modified:February 5, 2008 - v1
Checksum:i5EADCC3DA44C13A5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000896 Genomic DNA. Translation: ABX81114.1.
RefSeqiWP_012242445.1. NC_010163.1.

Genome annotation databases

EnsemblBacteriaiABX81114; ABX81114; ACL_0496.
KEGGiacl:ACL_0496.

Similar proteinsi

Entry informationi

Entry nameiACKA_ACHLI
AccessioniPrimary (citable) accession number: A9NFI4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: June 7, 2017
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families