Reviewed, UniProtKB/Swiss-Prot A9NF64 (UPPP_ACHLI)

Names and origin

Protein names

Recommended name:
    Undecaprenyl-diphosphatase
    EC=3.6.1.27
Alternative name(s):
    Undecaprenyl pyrophosphate phosphatase
    Bacitracin resistance protein

Gene names

Name:	uppP
Ordered Locus Names:	ACL_0372

Organism

Acholeplasma laidlawii (strain PG-8A) [Complete proteome] [HAMAP]

Taxonomic identifier

441768 [NCBI]

Taxonomic lineage

Bacteria › Tenericutes › Mollicutes › Acholeplasmatales › Acholeplasmataceae › Acholeplasma

Protein attributes

Sequence length	277 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity.
Catalytic activity	Undecaprenyl diphosphate + H2O = undecaprenyl phosphate + phosphate. HAMAP MF_01006
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP MF_01006
Sequence similarities	Belongs to the uppP family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 277	277	Undecaprenyl-diphosphatase HAMAP MF_01006		PRO_1000083973
Regions
	Transmembrane	3 – 23	21	Potential
	Transmembrane	48 – 68	21	Potential
	Transmembrane	97 – 117	21	Potential
	Transmembrane	125 – 145	21	Potential
	Transmembrane	198 – 218	21	Potential
	Transmembrane	227 – 247	21	Potential
	Transmembrane	257 – 277	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	A9NF64-1 [UniParc]. Last modified February 5, 2008. Version 1. Checksum: 550237FA32AAD918	FASTA	277	30,897
	10 20 30 40 50 60 MDYIIELIKY IILGIIQGVT EIFPVSSSGH LVLFSNLFLG GEDINATLTL FLMITNMGSF 70 80 90 100 110 120 LALLIYYFKD VKELVVDSFN FVFNKEKRKE IIVQENISYA VKLIIAIVPI GIAGLLIKDY 130 140 150 160 170 180 LPTNLLSIGI SLIITSLLLF LVFLLRNKKF SNDITFKNAG VIGLIQMFAV FPGISRSGIT 190 200 210 220 230 240 LVGGLSQKIE IKKVMRFSFL CYLLISIPVS GLGLYDAIKN PGTMSDIPGF SLAFIFSFIF 250 260 270 SLLTIKIMHK YVTVKNLIWF SLYALTVGLV SITLYII

References

[1]

"Acholeplasma laidlawii complete genome." Kovaleva G.Y., Kazanov M.D., Malko D.B., Vitreschak A.G., Sernova N.V., Gelfand M.S., Lazarev V.N., Levitskii S.A., Basovskii Y.I., Chukin M.M., Akopian T.A., Vereshchagin V.A., Kostrjukova E.S., Selezneva O.V., Vtyurin N.N., Rogov S.I., Alekseev D.G., Ladygina V.G. , Titova G.A., Karpov V.A., Govorun V.M. Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000896 Genomic DNA. Translation: ABX80994.1.
RefSeq	YP_001620370.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5804370.
GenomeReviews	Gene locus ACL_0372 in contig CP000896_GR.
KEGG	acl:ACL_0372.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	A9NF64. ITERNHI.
Family and domain databases
HAMAP	MF_01006. [Tree]
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
Pfam	PF02673. BacA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UPPP_ACHLI

Accession

Primary (citable) accession number: A9NF64

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	February 5, 2008
Last modified:	June 16, 2009
This is version 13 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)