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A9NF64 (UPPP_ACHLI) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Ordered Locus Names:ACL_0372
OrganismAcholeplasma laidlawii (strain PG-8A) [Complete proteome] [HAMAP]
Taxonomic identifier441768 [NCBI]
Taxonomic lineageBacteriaTenericutesMollicutesAcholeplasmatalesAcholeplasmataceaeAcholeplasma

Protein attributes

Sequence length277 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 277277Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_1000083973

Regions

Transmembrane3 – 2321Helical; Potential
Transmembrane48 – 6821Helical; Potential
Transmembrane97 – 11721Helical; Potential
Transmembrane125 – 14521Helical; Potential
Transmembrane198 – 21821Helical; Potential
Transmembrane227 – 24721Helical; Potential
Transmembrane257 – 27721Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
A9NF64 [UniParc].

Last modified February 5, 2008. Version 1.
Checksum: 550237FA32AAD918

FASTA27730,897
        10         20         30         40         50         60 
MDYIIELIKY IILGIIQGVT EIFPVSSSGH LVLFSNLFLG GEDINATLTL FLMITNMGSF 

        70         80         90        100        110        120 
LALLIYYFKD VKELVVDSFN FVFNKEKRKE IIVQENISYA VKLIIAIVPI GIAGLLIKDY 

       130        140        150        160        170        180 
LPTNLLSIGI SLIITSLLLF LVFLLRNKKF SNDITFKNAG VIGLIQMFAV FPGISRSGIT 

       190        200        210        220        230        240 
LVGGLSQKIE IKKVMRFSFL CYLLISIPVS GLGLYDAIKN PGTMSDIPGF SLAFIFSFIF 

       250        260        270 
SLLTIKIMHK YVTVKNLIWF SLYALTVGLV SITLYII 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000896 Genomic DNA. Translation: ABX80994.1.
RefSeqYP_001620370.1. NC_010163.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING441768.ACL_0372.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABX80994; ABX80994; ACL_0372.
GeneID5804370.
KEGGacl:ACL_0372.
PATRIC20637464. VBIAchLai134690_0356.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218357.
KOK06153.
OMAMGASKRS.
OrthoDBEOG6QP13M.

Enzyme and pathway databases

BioCycALAI441768:GI40-372-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUPPP_ACHLI
AccessionPrimary (citable) accession number: A9NF64
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: February 19, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families