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A9NET8

- SYL_ACHLI

UniProt

A9NET8 - SYL_ACHLI

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Acholeplasma laidlawii (strain PG-8A)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei584 – 5841ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciALAI441768:GI40-242-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:ACL_0242
OrganismiAcholeplasma laidlawii (strain PG-8A)
Taxonomic identifieri441768 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesAcholeplasmatalesAcholeplasmataceaeAcholeplasma
ProteomesiUP000008558: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 803803Leucine--tRNA ligasePRO_0000334722Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi441768.ACL_0242.

Structurei

3D structure databases

ProteinModelPortaliA9NET8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi41 – 5212"HIGH" regionAdd
BLAST
Motifi581 – 5855"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

A9NET8 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHKYEHRKIE EKWQKHWLDN KLFKTKNDRF HQKYYVLDMF PYPSASGLHV
60 70 80 90 100
GHIEGYTATD IVSRFKRMQG YNVLHPMGWD AYGLPSEQYA LATGKDPKSF
110 120 130 140 150
TYQNISNFKR QIIEMGKGVD WDKELATTDP EYFKWTQWIF KRLYEKGLAV
160 170 180 190 200
LKDVEVNWCE GLGTVLANDE IEIINGQMVS ERGHYPVIKK PMRQWVLRIT
210 220 230 240 250
EYADRLLDDL ALVDWPENLK EMQRNWIGKS SGAVIEFEVA STDYKFEIFT
260 270 280 290 300
TRPDTIYGVT YCVLSPEHPL VEKIVTQDEE KDVLRYIEQT KMKSDLDRIA
310 320 330 340 350
DKSKTGVFTG AFAKHPLTNQ LIPIWIGDYV LPQYGMGAVM AVPAHDDRDY
360 370 380 390 400
EFAMQYGLNI IEVIKGGSEG AYTGDGIHHH SGIIDGLYNE EAIEKITKHL
410 420 430 440 450
EDRKKGYKHY TYKLRDWVFS RQRYWGEPFP VIYDEDGQIH LVPDDELPLE
460 470 480 490 500
LPYLEFIKPS GTGESPLANA RDWLYVDING KKGRRDTNTM PQLAGSSWYY
510 520 530 540 550
IGYILKSNLG YIPLDSKEAK AVLDQFLPVD LYVGGTEHAV GHLLYARFWH
560 570 580 590 600
KFFYDLGFVS SKEPFMKLVN QGMILGADHS KMSKSKGNSV SPDDFIQSHG
610 620 630 640 650
ADALRLFEMF MGPLEAEKPW SNEGLEGAKR FLDRVWRMFD FEITQQPVDA
660 670 680 690 700
LQTVYHQTVK KVTEDYEKLA FNTAISQMMI FVNEVYKTKV IGAAQARGFL
710 720 730 740 750
KLLNPIAPHL TEEINETVLK HHEDLVYSEW PTYDESFLIE TEVEVAIQVN
760 770 780 790 800
GKLRGRLQVK KDMVEEDLKK LALEHENVIK HVEGLTIVKV IVIPNKIVNI

VVR
Length:803
Mass (Da):92,810
Last modified:February 5, 2008 - v1
Checksum:i4542359C0C2E5190
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000896 Genomic DNA. Translation: ABX80868.1.
RefSeqiYP_001620244.1. NC_010163.1.

Genome annotation databases

EnsemblBacteriaiABX80868; ABX80868; ACL_0242.
GeneIDi5804115.
KEGGiacl:ACL_0242.
PATRICi20637194. VBIAchLai134690_0224.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000896 Genomic DNA. Translation: ABX80868.1 .
RefSeqi YP_001620244.1. NC_010163.1.

3D structure databases

ProteinModelPortali A9NET8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 441768.ACL_0242.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABX80868 ; ABX80868 ; ACL_0242 .
GeneIDi 5804115.
KEGGi acl:ACL_0242.
PATRICi 20637194. VBIAchLai134690_0224.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci ALAI441768:GI40-242-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
Pfami PF08264. Anticodon_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PG-8A.

Entry informationi

Entry nameiSYL_ACHLI
AccessioniPrimary (citable) accession number: A9NET8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: October 29, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3