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A9NET8

- SYL_ACHLI

UniProt

A9NET8 - SYL_ACHLI

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Protein
Leucine--tRNA ligase
Gene
leuS, ACL_0242
Organism
Acholeplasma laidlawii (strain PG-8A)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei584 – 5841ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciALAI441768:GI40-242-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:ACL_0242
OrganismiAcholeplasma laidlawii (strain PG-8A)
Taxonomic identifieri441768 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesAcholeplasmatalesAcholeplasmataceaeAcholeplasma
ProteomesiUP000008558: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 803803Leucine--tRNA ligaseUniRule annotation
PRO_0000334722Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi441768.ACL_0242.

Structurei

3D structure databases

ProteinModelPortaliA9NET8.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi41 – 5212"HIGH" regionUniRule annotation
Add
BLAST
Motifi581 – 5855"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

A9NET8-1 [UniParc]FASTAAdd to Basket

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MHKYEHRKIE EKWQKHWLDN KLFKTKNDRF HQKYYVLDMF PYPSASGLHV    50
GHIEGYTATD IVSRFKRMQG YNVLHPMGWD AYGLPSEQYA LATGKDPKSF 100
TYQNISNFKR QIIEMGKGVD WDKELATTDP EYFKWTQWIF KRLYEKGLAV 150
LKDVEVNWCE GLGTVLANDE IEIINGQMVS ERGHYPVIKK PMRQWVLRIT 200
EYADRLLDDL ALVDWPENLK EMQRNWIGKS SGAVIEFEVA STDYKFEIFT 250
TRPDTIYGVT YCVLSPEHPL VEKIVTQDEE KDVLRYIEQT KMKSDLDRIA 300
DKSKTGVFTG AFAKHPLTNQ LIPIWIGDYV LPQYGMGAVM AVPAHDDRDY 350
EFAMQYGLNI IEVIKGGSEG AYTGDGIHHH SGIIDGLYNE EAIEKITKHL 400
EDRKKGYKHY TYKLRDWVFS RQRYWGEPFP VIYDEDGQIH LVPDDELPLE 450
LPYLEFIKPS GTGESPLANA RDWLYVDING KKGRRDTNTM PQLAGSSWYY 500
IGYILKSNLG YIPLDSKEAK AVLDQFLPVD LYVGGTEHAV GHLLYARFWH 550
KFFYDLGFVS SKEPFMKLVN QGMILGADHS KMSKSKGNSV SPDDFIQSHG 600
ADALRLFEMF MGPLEAEKPW SNEGLEGAKR FLDRVWRMFD FEITQQPVDA 650
LQTVYHQTVK KVTEDYEKLA FNTAISQMMI FVNEVYKTKV IGAAQARGFL 700
KLLNPIAPHL TEEINETVLK HHEDLVYSEW PTYDESFLIE TEVEVAIQVN 750
GKLRGRLQVK KDMVEEDLKK LALEHENVIK HVEGLTIVKV IVIPNKIVNI 800
VVR 803
Length:803
Mass (Da):92,810
Last modified:February 5, 2008 - v1
Checksum:i4542359C0C2E5190
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000896 Genomic DNA. Translation: ABX80868.1.
RefSeqiWP_012242199.1. NC_010163.1.
YP_001620244.1. NC_010163.1.

Genome annotation databases

EnsemblBacteriaiABX80868; ABX80868; ACL_0242.
GeneIDi5804115.
KEGGiacl:ACL_0242.
PATRICi20637194. VBIAchLai134690_0224.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000896 Genomic DNA. Translation: ABX80868.1 .
RefSeqi WP_012242199.1. NC_010163.1.
YP_001620244.1. NC_010163.1.

3D structure databases

ProteinModelPortali A9NET8.
ModBasei Search...

Protein-protein interaction databases

STRINGi 441768.ACL_0242.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABX80868 ; ABX80868 ; ACL_0242 .
GeneIDi 5804115.
KEGGi acl:ACL_0242.
PATRICi 20637194. VBIAchLai134690_0224.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci ALAI441768:GI40-242-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
Pfami PF08264. Anticodon_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PG-8A.

Entry informationi

Entry nameiSYL_ACHLI
AccessioniPrimary (citable) accession number: A9NET8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: September 3, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi