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A9NET8

- SYL_ACHLI

UniProt

A9NET8 - SYL_ACHLI

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Acholeplasma laidlawii (strain PG-8A)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (05 Feb 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei584 – 5841ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciALAI441768:GI40-242-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:ACL_0242
    OrganismiAcholeplasma laidlawii (strain PG-8A)
    Taxonomic identifieri441768 [NCBI]
    Taxonomic lineageiBacteriaTenericutesMollicutesAcholeplasmatalesAcholeplasmataceaeAcholeplasma
    ProteomesiUP000008558: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 803803Leucine--tRNA ligasePRO_0000334722Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi441768.ACL_0242.

    Structurei

    3D structure databases

    ProteinModelPortaliA9NET8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi41 – 5212"HIGH" regionAdd
    BLAST
    Motifi581 – 5855"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200748.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PfamiPF08264. Anticodon_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A9NET8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHKYEHRKIE EKWQKHWLDN KLFKTKNDRF HQKYYVLDMF PYPSASGLHV    50
    GHIEGYTATD IVSRFKRMQG YNVLHPMGWD AYGLPSEQYA LATGKDPKSF 100
    TYQNISNFKR QIIEMGKGVD WDKELATTDP EYFKWTQWIF KRLYEKGLAV 150
    LKDVEVNWCE GLGTVLANDE IEIINGQMVS ERGHYPVIKK PMRQWVLRIT 200
    EYADRLLDDL ALVDWPENLK EMQRNWIGKS SGAVIEFEVA STDYKFEIFT 250
    TRPDTIYGVT YCVLSPEHPL VEKIVTQDEE KDVLRYIEQT KMKSDLDRIA 300
    DKSKTGVFTG AFAKHPLTNQ LIPIWIGDYV LPQYGMGAVM AVPAHDDRDY 350
    EFAMQYGLNI IEVIKGGSEG AYTGDGIHHH SGIIDGLYNE EAIEKITKHL 400
    EDRKKGYKHY TYKLRDWVFS RQRYWGEPFP VIYDEDGQIH LVPDDELPLE 450
    LPYLEFIKPS GTGESPLANA RDWLYVDING KKGRRDTNTM PQLAGSSWYY 500
    IGYILKSNLG YIPLDSKEAK AVLDQFLPVD LYVGGTEHAV GHLLYARFWH 550
    KFFYDLGFVS SKEPFMKLVN QGMILGADHS KMSKSKGNSV SPDDFIQSHG 600
    ADALRLFEMF MGPLEAEKPW SNEGLEGAKR FLDRVWRMFD FEITQQPVDA 650
    LQTVYHQTVK KVTEDYEKLA FNTAISQMMI FVNEVYKTKV IGAAQARGFL 700
    KLLNPIAPHL TEEINETVLK HHEDLVYSEW PTYDESFLIE TEVEVAIQVN 750
    GKLRGRLQVK KDMVEEDLKK LALEHENVIK HVEGLTIVKV IVIPNKIVNI 800
    VVR 803
    Length:803
    Mass (Da):92,810
    Last modified:February 5, 2008 - v1
    Checksum:i4542359C0C2E5190
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000896 Genomic DNA. Translation: ABX80868.1.
    RefSeqiWP_012242199.1. NC_010163.1.
    YP_001620244.1. NC_010163.1.

    Genome annotation databases

    EnsemblBacteriaiABX80868; ABX80868; ACL_0242.
    GeneIDi5804115.
    KEGGiacl:ACL_0242.
    PATRICi20637194. VBIAchLai134690_0224.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000896 Genomic DNA. Translation: ABX80868.1 .
    RefSeqi WP_012242199.1. NC_010163.1.
    YP_001620244.1. NC_010163.1.

    3D structure databases

    ProteinModelPortali A9NET8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 441768.ACL_0242.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABX80868 ; ABX80868 ; ACL_0242 .
    GeneIDi 5804115.
    KEGGi acl:ACL_0242.
    PATRICi 20637194. VBIAchLai134690_0224.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200748.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci ALAI441768:GI40-242-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    Pfami PF08264. Anticodon_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PG-8A.

    Entry informationi

    Entry nameiSYL_ACHLI
    AccessioniPrimary (citable) accession number: A9NET8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: February 5, 2008
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3