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A9NEN3

- EFG_ACHLI

UniProt

A9NEN3 - EFG_ACHLI

Protein

Elongation factor G

Gene

fusA

Organism
Acholeplasma laidlawii (strain PG-8A)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (05 Feb 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi17 – 248GTPUniRule annotation
    Nucleotide bindingi81 – 855GTPUniRule annotation
    Nucleotide bindingi135 – 1384GTPUniRule annotation

    GO - Molecular functioni

    1. GTPase activity Source: InterPro
    2. GTP binding Source: UniProtKB-HAMAP
    3. translation elongation factor activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Elongation factor

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciALAI441768:GI40-187-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Elongation factor GUniRule annotation
    Short name:
    EF-GUniRule annotation
    Gene namesi
    Name:fusAUniRule annotation
    Ordered Locus Names:ACL_0187
    OrganismiAcholeplasma laidlawii (strain PG-8A)
    Taxonomic identifieri441768 [NCBI]
    Taxonomic lineageiBacteriaTenericutesMollicutesAcholeplasmatalesAcholeplasmataceaeAcholeplasma
    ProteomesiUP000008558: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 690690Elongation factor GPRO_1000074945Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi441768.ACL_0187.

    Structurei

    3D structure databases

    ProteinModelPortaliA9NEN3.
    SMRiA9NEN3. Positions 4-685.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini8 – 282275tr-type GAdd
    BLAST

    Sequence similaritiesi

    Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0480.
    HOGENOMiHOG000231585.
    KOiK02355.
    OMAiSGVQPQT.
    OrthoDBiEOG6X6RBF.

    Family and domain databases

    Gene3Di3.30.230.10. 1 hit.
    3.30.70.240. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPiMF_00054_B. EF_G_EF_2_B.
    InterProiIPR000795. EF_GTP-bd_dom.
    IPR009022. EFG_III-V.
    IPR000640. EFG_V.
    IPR027417. P-loop_NTPase.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
    IPR005225. Small_GTP-bd_dom.
    IPR009000. Transl_B-barrel.
    IPR004540. Transl_elong_EFG/EF2.
    IPR005517. Transl_elong_EFG/EF2_IV.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    [Graphical view]
    PfamiPF00679. EFG_C. 1 hit.
    PF14492. EFG_II. 1 hit.
    PF03764. EFG_IV. 1 hit.
    PF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 1 hit.
    [Graphical view]
    PRINTSiPR00315. ELONGATNFCT.
    SMARTiSM00838. EFG_C. 1 hit.
    SM00889. EFG_IV. 1 hit.
    [Graphical view]
    SUPFAMiSSF50447. SSF50447. 1 hit.
    SSF52540. SSF52540. 1 hit.
    SSF54211. SSF54211. 1 hit.
    SSF54980. SSF54980. 2 hits.
    TIGRFAMsiTIGR00484. EF-G. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEiPS00301. G_TR_1. 1 hit.
    PS51722. G_TR_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A9NEN3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPRQYSLKMT RNIGIMAHID AGKTTTTERI LFHTGKIHKT GETHDGASQM    50
    DWMAQEQERG ITITSAATTS VWRDHRVNII DTPGHVDFTV EVSRSLRVLD 100
    GAVTVIDAQA GVEPQTETVW RQATEYKVPR IVYVNKMDKI GADFNNAIKT 150
    LHRRLGVKAN AIQLPIGTEL DFSGIIDLVT MTAVEYSGDA LETTKEIPIP 200
    AHLEEQAIDM RNELIEAVAE FDDELMVTYL EGEEVSVELL KRAIRKGVLA 250
    VEFFPVVAGS SFKNKGVRKV LDAVIDYLPS PLDIPPVLGH TSEGVEVYRH 300
    ADDEEPFTAL AFKVMTDPFV GKLTFFRVYS GKIKSGSYVQ NTTKGERERF 350
    GRILQMHANT RQEIDEVYAG DIAAAVGLKV TTTGNTLATQ NDDIILESMN 400
    FPEPVIEVAV EPKTKNDQDK MGQALAKLAE EDPTFKTYTN TETGQTIIAG 450
    MGELHLDILV DRMKREFKVE ANVTEPQVSY RETLTVPNEI EAKFIRQSGG 500
    RGQYGHVVID FEPNPGKGFE FVDKIVGGVI PREYIPSVQK GLEEALGGGI 550
    LAGFPVVDIK ATLKFGSYHD VDSSEMAYKI AASMALKDAK NKANAVILEP 600
    IMDVEVVTPN DYVGNVIGDI TSRRGRLESQ EGRGNAISIR AFVPLSEMFG 650
    YATSLRSNTQ GRATFVMQFD HFDKVPKSIQ EEIIKKRGSN 690
    Length:690
    Mass (Da):76,335
    Last modified:February 5, 2008 - v1
    Checksum:iDAC5F17833FDCF3B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000896 Genomic DNA. Translation: ABX80813.1.
    RefSeqiYP_001620189.1. NC_010163.1.

    Genome annotation databases

    EnsemblBacteriaiABX80813; ABX80813; ACL_0187.
    GeneIDi5804183.
    KEGGiacl:ACL_0187.
    PATRICi20637084. VBIAchLai134690_0169.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000896 Genomic DNA. Translation: ABX80813.1 .
    RefSeqi YP_001620189.1. NC_010163.1.

    3D structure databases

    ProteinModelPortali A9NEN3.
    SMRi A9NEN3. Positions 4-685.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 441768.ACL_0187.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABX80813 ; ABX80813 ; ACL_0187 .
    GeneIDi 5804183.
    KEGGi acl:ACL_0187.
    PATRICi 20637084. VBIAchLai134690_0169.

    Phylogenomic databases

    eggNOGi COG0480.
    HOGENOMi HOG000231585.
    KOi K02355.
    OMAi SGVQPQT.
    OrthoDBi EOG6X6RBF.

    Enzyme and pathway databases

    BioCyci ALAI441768:GI40-187-MONOMER.

    Family and domain databases

    Gene3Di 3.30.230.10. 1 hit.
    3.30.70.240. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPi MF_00054_B. EF_G_EF_2_B.
    InterProi IPR000795. EF_GTP-bd_dom.
    IPR009022. EFG_III-V.
    IPR000640. EFG_V.
    IPR027417. P-loop_NTPase.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
    IPR005225. Small_GTP-bd_dom.
    IPR009000. Transl_B-barrel.
    IPR004540. Transl_elong_EFG/EF2.
    IPR005517. Transl_elong_EFG/EF2_IV.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    [Graphical view ]
    Pfami PF00679. EFG_C. 1 hit.
    PF14492. EFG_II. 1 hit.
    PF03764. EFG_IV. 1 hit.
    PF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 1 hit.
    [Graphical view ]
    PRINTSi PR00315. ELONGATNFCT.
    SMARTi SM00838. EFG_C. 1 hit.
    SM00889. EFG_IV. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50447. SSF50447. 1 hit.
    SSF52540. SSF52540. 1 hit.
    SSF54211. SSF54211. 1 hit.
    SSF54980. SSF54980. 2 hits.
    TIGRFAMsi TIGR00484. EF-G. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEi PS00301. G_TR_1. 1 hit.
    PS51722. G_TR_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PG-8A.

    Entry informationi

    Entry nameiEFG_ACHLI
    AccessioniPrimary (citable) accession number: A9NEN3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: February 5, 2008
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3