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A9NEN3 (EFG_ACHLI) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Elongation factor G

Short name=EF-G
Gene names
Name:fusA
Ordered Locus Names:ACL_0187
OrganismAcholeplasma laidlawii (strain PG-8A) [Complete proteome] [HAMAP]
Taxonomic identifier441768 [NCBI]
Taxonomic lineageBacteriaTenericutesMollicutesAcholeplasmatalesAcholeplasmataceaeAcholeplasma

Protein attributes

Sequence length690 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome By similarity. HAMAP-Rule MF_00054

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00054.

Sequence similarities

Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandGTP-binding
Nucleotide-binding
   Molecular functionElongation factor
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionGTP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

GTPase activity

Inferred from electronic annotation. Source: InterPro

translation elongation factor activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 690690Elongation factor G HAMAP-Rule MF_00054
PRO_1000074945

Regions

Nucleotide binding17 – 248GTP By similarity
Nucleotide binding81 – 855GTP By similarity
Nucleotide binding135 – 1384GTP By similarity

Sequences

Sequence LengthMass (Da)Tools
A9NEN3 [UniParc].

Last modified February 5, 2008. Version 1.
Checksum: DAC5F17833FDCF3B

FASTA69076,335
        10         20         30         40         50         60 
MPRQYSLKMT RNIGIMAHID AGKTTTTERI LFHTGKIHKT GETHDGASQM DWMAQEQERG 

        70         80         90        100        110        120 
ITITSAATTS VWRDHRVNII DTPGHVDFTV EVSRSLRVLD GAVTVIDAQA GVEPQTETVW 

       130        140        150        160        170        180 
RQATEYKVPR IVYVNKMDKI GADFNNAIKT LHRRLGVKAN AIQLPIGTEL DFSGIIDLVT 

       190        200        210        220        230        240 
MTAVEYSGDA LETTKEIPIP AHLEEQAIDM RNELIEAVAE FDDELMVTYL EGEEVSVELL 

       250        260        270        280        290        300 
KRAIRKGVLA VEFFPVVAGS SFKNKGVRKV LDAVIDYLPS PLDIPPVLGH TSEGVEVYRH 

       310        320        330        340        350        360 
ADDEEPFTAL AFKVMTDPFV GKLTFFRVYS GKIKSGSYVQ NTTKGERERF GRILQMHANT 

       370        380        390        400        410        420 
RQEIDEVYAG DIAAAVGLKV TTTGNTLATQ NDDIILESMN FPEPVIEVAV EPKTKNDQDK 

       430        440        450        460        470        480 
MGQALAKLAE EDPTFKTYTN TETGQTIIAG MGELHLDILV DRMKREFKVE ANVTEPQVSY 

       490        500        510        520        530        540 
RETLTVPNEI EAKFIRQSGG RGQYGHVVID FEPNPGKGFE FVDKIVGGVI PREYIPSVQK 

       550        560        570        580        590        600 
GLEEALGGGI LAGFPVVDIK ATLKFGSYHD VDSSEMAYKI AASMALKDAK NKANAVILEP 

       610        620        630        640        650        660 
IMDVEVVTPN DYVGNVIGDI TSRRGRLESQ EGRGNAISIR AFVPLSEMFG YATSLRSNTQ 

       670        680        690 
GRATFVMQFD HFDKVPKSIQ EEIIKKRGSN 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000896 Genomic DNA. Translation: ABX80813.1.
RefSeqYP_001620189.1. NC_010163.1.

3D structure databases

ProteinModelPortalA9NEN3.
SMRA9NEN3. Positions 4-685.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING441768.ACL_0187.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABX80813; ABX80813; ACL_0187.
GeneID5804183.
KEGGacl:ACL_0187.
PATRIC20637084. VBIAchLai134690_0169.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0480.
HOGENOMHOG000231585.
KOK02355.
OMASGVQPQT.
OrthoDBEOG6X6RBF.

Enzyme and pathway databases

BioCycALAI441768:GI40-187-MONOMER.

Family and domain databases

Gene3D3.30.230.10. 1 hit.
3.30.70.240. 1 hit.
3.40.50.300. 1 hit.
HAMAPMF_00054_B. EF_G_EF_2_B.
InterProIPR000795. EF_GTP-bd_dom.
IPR009022. EFG_III-V.
IPR000640. EFG_V.
IPR027417. P-loop_NTPase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
IPR005225. Small_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR004540. Transl_elong_EFG/EF2.
IPR005517. Transl_elong_EFG/EF2_IV.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view]
PfamPF00679. EFG_C. 1 hit.
PF14492. EFG_II. 1 hit.
PF03764. EFG_IV. 1 hit.
PF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
[Graphical view]
PRINTSPR00315. ELONGATNFCT.
SMARTSM00838. EFG_C. 1 hit.
SM00889. EFG_IV. 1 hit.
[Graphical view]
SUPFAMSSF50447. SSF50447. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF54211. SSF54211. 1 hit.
SSF54980. SSF54980. 2 hits.
TIGRFAMsTIGR00484. EF-G. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEPS00301. EFACTOR_GTP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameEFG_ACHLI
AccessionPrimary (citable) accession number: A9NEN3
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: May 14, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families