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A9NEC0

- A9NEC0_ACHLI

UniProt

A9NEC0 - A9NEC0_ACHLI

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Protein

Thymidine kinase

Gene

tdk

Organism
Acholeplasma laidlawii (strain PG-8A)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei90 – 901Proton acceptorUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi15 – 228ATPUniRule annotation
Nucleotide bindingi89 – 924ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotation, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciALAI441768:GI40-58-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotationImported
Ordered Locus Names:ACL_0058Imported
OrganismiAcholeplasma laidlawii (strain PG-8A)Imported
Taxonomic identifieri441768 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesAcholeplasmatalesAcholeplasmataceaeAcholeplasma
ProteomesiUP000008558: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi441768.ACL_0058.

Structurei

3D structure databases

ProteinModelPortaliA9NEC0.
SMRiA9NEC0. Positions 1-193.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1435.
HOGENOMiHOG000076390.
KOiK00857.
OMAiDHISEST.
OrthoDBiEOG69D3J2.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

A9NEC0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MYHTYRNGFI EVVCGPMFAG KTEELIRRAK RLKYAKQNYL VFKPVIDNRY
60 70 80 90 100
SSKAEIVSHS LLTENAILIE KSKDILEHMN DSIEAVIIDE AQFFDQDIVE
110 120 130 140 150
IADRLADSGV RVIIGGLDRD FKGEPFGPMP QLLAIAEFVV KLTAICPKTG
160 170 180 190
TPATRTQRII NGKPARMDDP LIVVGASDSY EPRSRHAHEV PGKYDKK
Length:197
Mass (Da):22,162
Last modified:February 5, 2008 - v1
Checksum:iF62B2CABF391F17E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000896 Genomic DNA. Translation: ABX80700.1.
RefSeqiWP_012242031.1. NC_010163.1.
YP_001620076.1. NC_010163.1.

Genome annotation databases

EnsemblBacteriaiABX80700; ABX80700; ACL_0058.
GeneIDi5803667.
KEGGiacl:ACL_0058.
PATRICi20636834. VBIAchLai134690_0059.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000896 Genomic DNA. Translation: ABX80700.1 .
RefSeqi WP_012242031.1. NC_010163.1.
YP_001620076.1. NC_010163.1.

3D structure databases

ProteinModelPortali A9NEC0.
SMRi A9NEC0. Positions 1-193.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 441768.ACL_0058.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABX80700 ; ABX80700 ; ACL_0058 .
GeneIDi 5803667.
KEGGi acl:ACL_0058.
PATRICi 20636834. VBIAchLai134690_0059.

Phylogenomic databases

eggNOGi COG1435.
HOGENOMi HOG000076390.
KOi K00857.
OMAi DHISEST.
OrthoDBi EOG69D3J2.

Enzyme and pathway databases

BioCyci ALAI441768:GI40-58-MONOMER.

Family and domain databases

HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PG-8AImported.

Entry informationi

Entry nameiA9NEC0_ACHLI
AccessioniPrimary (citable) accession number: A9NEC0
Entry historyi
Integrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: November 26, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3