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Protein

Thymidine kinase

Gene

tdk

Organism
Acholeplasma laidlawii (strain PG-8A)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei90Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi15 – 22ATPUniRule annotation8
Nucleotide bindingi89 – 92ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase
Biological processDNA synthesisUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciALAI441768:G1GAM-59-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotationImported
Ordered Locus Names:ACL_0058Imported
OrganismiAcholeplasma laidlawii (strain PG-8A)Imported
Taxonomic identifieri441768 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesAcholeplasmatalesAcholeplasmataceaeAcholeplasma
Proteomesi
  • UP000008558 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi441768.ACL_0058

Structurei

3D structure databases

ProteinModelPortaliA9NEC0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107T8J Bacteria
COG1435 LUCA
HOGENOMiHOG000076390
KOiK00857
OMAiKEQFGWI
OrthoDBiPOG091H0659

Family and domain databases

HAMAPiMF_00124 Thymidine_kinase, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR001267 Thymidine_kinase
PANTHERiPTHR11441 PTHR11441, 1 hit
PfamiView protein in Pfam
PF00265 TK, 1 hit
PIRSFiPIRSF035805 TK_cell, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit

Sequencei

Sequence statusi: Complete.

A9NEC0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYHTYRNGFI EVVCGPMFAG KTEELIRRAK RLKYAKQNYL VFKPVIDNRY
60 70 80 90 100
SSKAEIVSHS LLTENAILIE KSKDILEHMN DSIEAVIIDE AQFFDQDIVE
110 120 130 140 150
IADRLADSGV RVIIGGLDRD FKGEPFGPMP QLLAIAEFVV KLTAICPKTG
160 170 180 190
TPATRTQRII NGKPARMDDP LIVVGASDSY EPRSRHAHEV PGKYDKK
Length:197
Mass (Da):22,162
Last modified:February 5, 2008 - v1
Checksum:iF62B2CABF391F17E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000896 Genomic DNA Translation: ABX80700.1
RefSeqiWP_012242031.1, NC_010163.1

Genome annotation databases

EnsemblBacteriaiABX80700; ABX80700; ACL_0058
KEGGiacl:ACL_0058

Similar proteinsi

Entry informationi

Entry nameiA9NEC0_ACHLI
AccessioniPrimary (citable) accession number: A9NEC0
Entry historyiIntegrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: March 28, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health