A9NEC0 (A9NEC0_ACHLI) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Thymidine kinase HAMAP MF_00124
EC=2.7.1.21 HAMAP MF_00124

Gene names

Name:	tdk HAMAP MF_00124 EMBL ABX80700.1
Ordered Locus Names:	ACL_0058

Organism

Acholeplasma laidlawii (strain PG-8A) [Complete proteome] [HAMAP]

Taxonomic identifier

441768 [NCBI]

Taxonomic lineage

Bacteria › Tenericutes › Mollicutes › Acholeplasmatales › Acholeplasmataceae › Acholeplasma

Protein attributes

Sequence length	197 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + thymidine = ADP + thymidine 5'-phosphate. HAMAP MF_00124 SAAS SAAS020634
Subunit structure	Homotetramer By similarity. HAMAP MF_00124
Subcellular location	Cytoplasm By similarity HAMAP MF_00124.
Sequence similarities	Belongs to the thymidine kinase family. HAMAP MF_00124

Ontologies

Keywords
Biological process	DNA synthesis HAMAP MF_00124 SAAS SAAS020634
Cellular component	Cytoplasm HAMAP MF_00124
Ligand	ATP-binding HAMAP MF_00124 SAAS SAAS020634 Nucleotide-binding
Molecular function	Kinase HAMAP MF_00124 SAAS SAAS020634 EMBL ABX80700.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA replication Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP thymidine kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	15 – 22	8	ATP By similarity HAMAP MF_00124
	Nucleotide binding	89 – 92	4	ATP By similarity HAMAP MF_00124
Sites
	Active site	90	1	Proton acceptor By similarity HAMAP MF_00124

Sequences

	Sequence		Length	Mass (Da)
	A9NEC0 [UniParc]. Last modified February 5, 2008. Version 1. Checksum: F62B2CABF391F17E	FASTA	197	22,162
	10 20 30 40 50 60 MYHTYRNGFI EVVCGPMFAG KTEELIRRAK RLKYAKQNYL VFKPVIDNRY SSKAEIVSHS 70 80 90 100 110 120 LLTENAILIE KSKDILEHMN DSIEAVIIDE AQFFDQDIVE IADRLADSGV RVIIGGLDRD 130 140 150 160 170 180 FKGEPFGPMP QLLAIAEFVV KLTAICPKTG TPATRTQRII NGKPARMDDP LIVVGASDSY 190 EPRSRHAHEV PGKYDKK

References

[1]

"Complete genome and proteome of Acholeplasma laidlawii." Lazarev V.N., Levitskii S.A., Basovskii Y.I., Chukin M.M., Akopian T.A., Vereshchagin V.V., Kostrjukova E.S., Kovaleva G.Y., Kazanov M.D., Malko D.B., Vitreschak A.G., Sernova N.V., Gelfand M.S., Demina I.A., Serebryakova M.V., Galyamina M.A., Vtyurin N.N., Rogov S.I. , Alexeev D.G., Ladygina V.G., Govorun V.M. J. Bacteriol. 193:4943-4953(2011) [PubMed: 21784942] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PG-8A.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000896 Genomic DNA. Translation: ABX80700.1.
RefSeq	YP_001620076.1. NC_010163.1.
3D structure databases
ProteinModelPortal	A9NEC0.
SMR	A9NEC0. Positions 1-193.
ModBase	Search...
Protein-protein interaction databases
STRING	A9NEC0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5803667.
GenomeReviews	Gene locus ACL_0058 in contig CP000896_GR.
KEGG	acl:ACL_0058.
PATRIC	20636834. VBIAchLai134690_0059.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG522108.
OMA	EPRCRHH.
Family and domain databases
HAMAP	MF_00124. Thymidine_kinase. [Tree]
InterPro	IPR001267. Thymidine_kinase. IPR020634. Thymidine_kinase_subgr. [Graphical view]
KO	K00857.
PANTHER	PTHR11441. TK_cell. 1 hit.
Pfam	PF00265. TK. 1 hit. [Graphical view]
PIRSF	PIRSF035805. TK_cell. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A9NEC0_ACHLI

Accession

Primary (citable) accession number: A9NEC0

Entry history

Integrated into UniProtKB/TrEMBL:	February 5, 2008
Last sequence update:	February 5, 2008
Last modified:	January 25, 2012
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)