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Protein

Thymidine kinase

Gene

tdk

Organism
Acholeplasma laidlawii (strain PG-8A)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei90 – 901Proton acceptorUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi15 – 228ATPUniRule annotation
Nucleotide bindingi89 – 924ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotation, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciALAI441768:GI40-58-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotationImported
Ordered Locus Names:ACL_0058Imported
OrganismiAcholeplasma laidlawii (strain PG-8A)Imported
Taxonomic identifieri441768 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesAcholeplasmatalesAcholeplasmataceaeAcholeplasma
ProteomesiUP000008558 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi441768.ACL_0058.

Structurei

3D structure databases

ProteinModelPortaliA9NEC0.
SMRiA9NEC0. Positions 1-193.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1435.
HOGENOMiHOG000076390.
KOiK00857.
OMAiGWMEVIC.
OrthoDBiEOG69D3J2.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

A9NEC0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYHTYRNGFI EVVCGPMFAG KTEELIRRAK RLKYAKQNYL VFKPVIDNRY
60 70 80 90 100
SSKAEIVSHS LLTENAILIE KSKDILEHMN DSIEAVIIDE AQFFDQDIVE
110 120 130 140 150
IADRLADSGV RVIIGGLDRD FKGEPFGPMP QLLAIAEFVV KLTAICPKTG
160 170 180 190
TPATRTQRII NGKPARMDDP LIVVGASDSY EPRSRHAHEV PGKYDKK
Length:197
Mass (Da):22,162
Last modified:February 5, 2008 - v1
Checksum:iF62B2CABF391F17E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000896 Genomic DNA. Translation: ABX80700.1.
RefSeqiWP_012242031.1. NC_010163.1.
YP_001620076.1. NC_010163.1.

Genome annotation databases

EnsemblBacteriaiABX80700; ABX80700; ACL_0058.
KEGGiacl:ACL_0058.
PATRICi20636834. VBIAchLai134690_0059.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000896 Genomic DNA. Translation: ABX80700.1.
RefSeqiWP_012242031.1. NC_010163.1.
YP_001620076.1. NC_010163.1.

3D structure databases

ProteinModelPortaliA9NEC0.
SMRiA9NEC0. Positions 1-193.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi441768.ACL_0058.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABX80700; ABX80700; ACL_0058.
KEGGiacl:ACL_0058.
PATRICi20636834. VBIAchLai134690_0059.

Phylogenomic databases

eggNOGiCOG1435.
HOGENOMiHOG000076390.
KOiK00857.
OMAiGWMEVIC.
OrthoDBiEOG69D3J2.

Enzyme and pathway databases

BioCyciALAI441768:GI40-58-MONOMER.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PG-8AImported.

Entry informationi

Entry nameiA9NEC0_ACHLI
AccessioniPrimary (citable) accession number: A9NEC0
Entry historyi
Integrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: May 27, 2015
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.