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A9NE95 (FTHS_ACHLI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:ACL_0032
OrganismAcholeplasma laidlawii (strain PG-8A) [Complete proteome] [HAMAP]
Taxonomic identifier441768 [NCBI]
Taxonomic lineageBacteriaTenericutesMollicutesAcholeplasmatalesAcholeplasmataceaeAcholeplasma

Protein attributes

Sequence length527 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 527527Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_0000333311

Regions

Nucleotide binding53 – 608ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
A9NE95 [UniParc].

Last modified February 5, 2008. Version 1.
Checksum: 7C37DFF8C7435489

FASTA52758,201
        10         20         30         40         50         60 
MNTYNYLIDE LHILDDEIIS YGKDKFKIEL SLQERLKDKA PGKLILVTSI NPTSSGEGKT 

        70         80         90        100        110        120 
TLSIGLAQGF KKNGKDVMLA LREPSMGPVF GMKGGATGGG VSILEPSLDI DLHFNGDIHA 

       130        140        150        160        170        180 
LTSANNLLSA IIDNHMYFGN ELNIKDVYWQ RALDVNDRSL REVKTKARDD KFTITAASEM 

       190        200        210        220        230        240 
MAILALARDF KDLKERLNNI LIGTDKDGKD LFVSDLKCAD SLALLLKDAI KPNLVFAKEM 

       250        260        270        280        290        300 
VPALVHAGPF ANIAHGCNSV IATNTALKLA DYVITEAGFG ADLGMEKFLH IKQPHLYTKA 

       310        320        330        340        350        360 
SVVVVVATIK ALKLHGGVTE SNLDEPNIEA LSKGLENIEK HLENIKLFGL NSVVALNKFD 

       370        380        390        400        410        420 
TDSEEELQFL KNWARINHLN YGISEGYSKG GEGTKDLAKL VEKVAYEPSK FKRIYSNEEN 

       430        440        450        460        470        480 
HEYKIRKIAE NIYGAKDVIF SQQAKKKLNQ YKHLEIPICI AKTPLSLSGD PKLKGRPRDF 

       490        500        510        520 
VLEISDIKVS LGANLLVVLT KGINTMPGLN NRPRALDFKL DDKGELI 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000896 Genomic DNA. Translation: ABX80675.1.
RefSeqYP_001620051.1. NC_010163.1.

3D structure databases

ProteinModelPortalA9NE95.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING441768.ACL_0032.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABX80675; ABX80675; ACL_0032.
GeneID5803464.
KEGGacl:ACL_0032.
PATRIC20636782. VBIAchLai134690_0033.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OMACGEIMTM.
OrthoDBEOG6PCPSP.

Enzyme and pathway databases

BioCycALAI441768:GI40-32-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
ProtoNetSearch...

Entry information

Entry nameFTHS_ACHLI
AccessionPrimary (citable) accession number: A9NE95
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: April 16, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways