Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

A9NE95

- FTHS_ACHLI

UniProt

A9NE95 - FTHS_ACHLI

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Acholeplasma laidlawii (strain PG-8A)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 40 (01 Oct 2014)
      Sequence version 1 (05 Feb 2008)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi53 – 608ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciALAI441768:GI40-32-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:ACL_0032
    OrganismiAcholeplasma laidlawii (strain PG-8A)
    Taxonomic identifieri441768 [NCBI]
    Taxonomic lineageiBacteriaTenericutesMollicutesAcholeplasmatalesAcholeplasmataceaeAcholeplasma
    ProteomesiUP000008558: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 527527Formate--tetrahydrofolate ligasePRO_0000333311Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi441768.ACL_0032.

    Structurei

    3D structure databases

    ProteinModelPortaliA9NE95.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiLKHHGGV.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A9NE95-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNTYNYLIDE LHILDDEIIS YGKDKFKIEL SLQERLKDKA PGKLILVTSI    50
    NPTSSGEGKT TLSIGLAQGF KKNGKDVMLA LREPSMGPVF GMKGGATGGG 100
    VSILEPSLDI DLHFNGDIHA LTSANNLLSA IIDNHMYFGN ELNIKDVYWQ 150
    RALDVNDRSL REVKTKARDD KFTITAASEM MAILALARDF KDLKERLNNI 200
    LIGTDKDGKD LFVSDLKCAD SLALLLKDAI KPNLVFAKEM VPALVHAGPF 250
    ANIAHGCNSV IATNTALKLA DYVITEAGFG ADLGMEKFLH IKQPHLYTKA 300
    SVVVVVATIK ALKLHGGVTE SNLDEPNIEA LSKGLENIEK HLENIKLFGL 350
    NSVVALNKFD TDSEEELQFL KNWARINHLN YGISEGYSKG GEGTKDLAKL 400
    VEKVAYEPSK FKRIYSNEEN HEYKIRKIAE NIYGAKDVIF SQQAKKKLNQ 450
    YKHLEIPICI AKTPLSLSGD PKLKGRPRDF VLEISDIKVS LGANLLVVLT 500
    KGINTMPGLN NRPRALDFKL DDKGELI 527
    Length:527
    Mass (Da):58,201
    Last modified:February 5, 2008 - v1
    Checksum:i7C37DFF8C7435489
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000896 Genomic DNA. Translation: ABX80675.1.
    RefSeqiYP_001620051.1. NC_010163.1.

    Genome annotation databases

    EnsemblBacteriaiABX80675; ABX80675; ACL_0032.
    GeneIDi5803464.
    KEGGiacl:ACL_0032.
    PATRICi20636782. VBIAchLai134690_0033.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000896 Genomic DNA. Translation: ABX80675.1 .
    RefSeqi YP_001620051.1. NC_010163.1.

    3D structure databases

    ProteinModelPortali A9NE95.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 441768.ACL_0032.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABX80675 ; ABX80675 ; ACL_0032 .
    GeneIDi 5803464.
    KEGGi acl:ACL_0032.
    PATRICi 20636782. VBIAchLai134690_0033.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi LKHHGGV.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci ALAI441768:GI40-32-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PG-8A.

    Entry informationi

    Entry nameiFTHS_ACHLI
    AccessioniPrimary (citable) accession number: A9NE95
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: February 5, 2008
    Last modified: October 1, 2014
    This is version 40 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3