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A9NE95

- FTHS_ACHLI

UniProt

A9NE95 - FTHS_ACHLI

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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Acholeplasma laidlawii (strain PG-8A)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi53 – 608ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciALAI441768:GI40-32-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:ACL_0032
OrganismiAcholeplasma laidlawii (strain PG-8A)
Taxonomic identifieri441768 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesAcholeplasmatalesAcholeplasmataceaeAcholeplasma
ProteomesiUP000008558: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 527527Formate--tetrahydrofolate ligasePRO_0000333311Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi441768.ACL_0032.

Structurei

3D structure databases

ProteinModelPortaliA9NE95.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

A9NE95-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNTYNYLIDE LHILDDEIIS YGKDKFKIEL SLQERLKDKA PGKLILVTSI
60 70 80 90 100
NPTSSGEGKT TLSIGLAQGF KKNGKDVMLA LREPSMGPVF GMKGGATGGG
110 120 130 140 150
VSILEPSLDI DLHFNGDIHA LTSANNLLSA IIDNHMYFGN ELNIKDVYWQ
160 170 180 190 200
RALDVNDRSL REVKTKARDD KFTITAASEM MAILALARDF KDLKERLNNI
210 220 230 240 250
LIGTDKDGKD LFVSDLKCAD SLALLLKDAI KPNLVFAKEM VPALVHAGPF
260 270 280 290 300
ANIAHGCNSV IATNTALKLA DYVITEAGFG ADLGMEKFLH IKQPHLYTKA
310 320 330 340 350
SVVVVVATIK ALKLHGGVTE SNLDEPNIEA LSKGLENIEK HLENIKLFGL
360 370 380 390 400
NSVVALNKFD TDSEEELQFL KNWARINHLN YGISEGYSKG GEGTKDLAKL
410 420 430 440 450
VEKVAYEPSK FKRIYSNEEN HEYKIRKIAE NIYGAKDVIF SQQAKKKLNQ
460 470 480 490 500
YKHLEIPICI AKTPLSLSGD PKLKGRPRDF VLEISDIKVS LGANLLVVLT
510 520
KGINTMPGLN NRPRALDFKL DDKGELI
Length:527
Mass (Da):58,201
Last modified:February 5, 2008 - v1
Checksum:i7C37DFF8C7435489
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000896 Genomic DNA. Translation: ABX80675.1.
RefSeqiWP_012242006.1. NC_010163.1.
YP_001620051.1. NC_010163.1.

Genome annotation databases

EnsemblBacteriaiABX80675; ABX80675; ACL_0032.
GeneIDi5803464.
KEGGiacl:ACL_0032.
PATRICi20636782. VBIAchLai134690_0033.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000896 Genomic DNA. Translation: ABX80675.1 .
RefSeqi WP_012242006.1. NC_010163.1.
YP_001620051.1. NC_010163.1.

3D structure databases

ProteinModelPortali A9NE95.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 441768.ACL_0032.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABX80675 ; ABX80675 ; ACL_0032 .
GeneIDi 5803464.
KEGGi acl:ACL_0032.
PATRICi 20636782. VBIAchLai134690_0033.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci ALAI441768:GI40-32-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PG-8A.

Entry informationi

Entry nameiFTHS_ACHLI
AccessioniPrimary (citable) accession number: A9NE95
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: November 26, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3