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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Acholeplasma laidlawii (strain PG-8A)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi: tetrahydrofolate interconversion

This protein is involved in the pathway tetrahydrofolate interconversion, which is part of One-carbon metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway tetrahydrofolate interconversion and in One-carbon metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi53 – 60ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processOne-carbon metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:ACL_0032
OrganismiAcholeplasma laidlawii (strain PG-8A)
Taxonomic identifieri441768 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesAcholeplasmatalesAcholeplasmataceaeAcholeplasma
Proteomesi
  • UP000008558 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003333111 – 527Formate--tetrahydrofolate ligaseAdd BLAST527

Interactioni

Protein-protein interaction databases

STRINGi441768.ACL_0032.

Structurei

3D structure databases

ProteinModelPortaliA9NE95.
SMRiA9NE95.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CKU. Bacteria.
COG2759. LUCA.
HOGENOMiHOG000040280.
KOiK01938.
OMAiCGEIMTM.
OrthoDBiPOG091H01S8.

Family and domain databases

HAMAPiMF_01543. FTHFS. 1 hit.
InterProiView protein in InterPro
IPR000559. Formate_THF_ligase.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF01268. FTHFS. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

A9NE95-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTYNYLIDE LHILDDEIIS YGKDKFKIEL SLQERLKDKA PGKLILVTSI
60 70 80 90 100
NPTSSGEGKT TLSIGLAQGF KKNGKDVMLA LREPSMGPVF GMKGGATGGG
110 120 130 140 150
VSILEPSLDI DLHFNGDIHA LTSANNLLSA IIDNHMYFGN ELNIKDVYWQ
160 170 180 190 200
RALDVNDRSL REVKTKARDD KFTITAASEM MAILALARDF KDLKERLNNI
210 220 230 240 250
LIGTDKDGKD LFVSDLKCAD SLALLLKDAI KPNLVFAKEM VPALVHAGPF
260 270 280 290 300
ANIAHGCNSV IATNTALKLA DYVITEAGFG ADLGMEKFLH IKQPHLYTKA
310 320 330 340 350
SVVVVVATIK ALKLHGGVTE SNLDEPNIEA LSKGLENIEK HLENIKLFGL
360 370 380 390 400
NSVVALNKFD TDSEEELQFL KNWARINHLN YGISEGYSKG GEGTKDLAKL
410 420 430 440 450
VEKVAYEPSK FKRIYSNEEN HEYKIRKIAE NIYGAKDVIF SQQAKKKLNQ
460 470 480 490 500
YKHLEIPICI AKTPLSLSGD PKLKGRPRDF VLEISDIKVS LGANLLVVLT
510 520
KGINTMPGLN NRPRALDFKL DDKGELI
Length:527
Mass (Da):58,201
Last modified:February 5, 2008 - v1
Checksum:i7C37DFF8C7435489
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000896 Genomic DNA. Translation: ABX80675.1.
RefSeqiWP_012242006.1. NC_010163.1.

Genome annotation databases

EnsemblBacteriaiABX80675; ABX80675; ACL_0032.
KEGGiacl:ACL_0032.
PATRICi20636782. VBIAchLai134690_0033.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000896 Genomic DNA. Translation: ABX80675.1.
RefSeqiWP_012242006.1. NC_010163.1.

3D structure databases

ProteinModelPortaliA9NE95.
SMRiA9NE95.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi441768.ACL_0032.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABX80675; ABX80675; ACL_0032.
KEGGiacl:ACL_0032.
PATRICi20636782. VBIAchLai134690_0033.

Phylogenomic databases

eggNOGiENOG4105CKU. Bacteria.
COG2759. LUCA.
HOGENOMiHOG000040280.
KOiK01938.
OMAiCGEIMTM.
OrthoDBiPOG091H01S8.

Enzyme and pathway databases

UniPathwayiUPA00193.

Family and domain databases

HAMAPiMF_01543. FTHFS. 1 hit.
InterProiView protein in InterPro
IPR000559. Formate_THF_ligase.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF01268. FTHFS. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFTHS_ACHLI
AccessioniPrimary (citable) accession number: A9NE95
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: April 12, 2017
This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.