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A9NDB3

- GCH1_COXBR

UniProt

A9NDB3 - GCH1_COXBR

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Protein
GTP cyclohydrolase 1
Gene
folE, COXBURSA331_A1153
Organism
Coxiella burnetii (strain RSA 331 / Henzerling II)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi75 – 751Zinc By similarity
Metal bindingi78 – 781Zinc By similarity
Metal bindingi146 – 1461Zinc By similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW
  2. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
  2. one-carbon metabolic process Source: UniProtKB-HAMAP
  3. tetrahydrofolate biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

GTP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciCBUR360115:GI0X-1159-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase 1 (EC:3.5.4.16)
Alternative name(s):
GTP cyclohydrolase I
Short name:
GTP-CH-I
Gene namesi
Name:folE
Ordered Locus Names:COXBURSA331_A1153
OrganismiCoxiella burnetii (strain RSA 331 / Henzerling II)
Taxonomic identifieri360115 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
ProteomesiUP000008557: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 184184GTP cyclohydrolase 1UniRule annotation
PRO_1000078139Add
BLAST

Proteomic databases

PRIDEiA9NDB3.

Interactioni

Subunit structurei

Homopolymer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi360115.COXBURSA331_A1153.

Structurei

3D structure databases

ProteinModelPortaliA9NDB3.
SMRiA9NDB3. Positions 13-183.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0302.
HOGENOMiHOG000221222.
KOiK01495.
OMAiPRAYMER.
OrthoDBiEOG6XHC8G.

Family and domain databases

HAMAPiMF_00223. FolE.
InterProiIPR001474. GTP_CycHdrlase_I.
IPR018234. GTP_CycHdrlase_I_CS.
IPR020602. GTP_CycHdrlase_I_dom.
[Graphical view]
PANTHERiPTHR11109. PTHR11109. 1 hit.
PfamiPF01227. GTP_cyclohydroI. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00063. folE. 1 hit.
PROSITEiPS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
PS00860. GTP_CYCLOHYDROL_1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9NDB3-1 [UniParc]FASTAAdd to Basket

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MSNTIADHVK AILIALGEDP NREGLRDTPK RYEKALEHLT KGYHEKLPSV    50
VKKAVFQSGM DEMVILKDIE LYSLCEHHLL PFIGRCHVAY LPSGKIIGIS 100
KLARIVDMFA KRLQVQENLT KQIAEAILTA TEAKGVGVII EAKHLCMMMR 150
GVEKQNSEMT TSVMLGTFRK DDRTRSEFLS LIRK 184
Length:184
Mass (Da):20,777
Last modified:February 5, 2008 - v1
Checksum:iC69EA3EA9C15ABA4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000890 Genomic DNA. Translation: ABX77366.1.
RefSeqiWP_005768934.1. NC_010117.1.
YP_001596903.1. NC_010117.1.

Genome annotation databases

EnsemblBacteriaiABX77366; ABX77366; COXBURSA331_A1153.
GeneIDi5793676.
KEGGicbs:COXBURSA331_A1153.
PATRICi17926568. VBICoxBur33747_1159.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000890 Genomic DNA. Translation: ABX77366.1 .
RefSeqi WP_005768934.1. NC_010117.1.
YP_001596903.1. NC_010117.1.

3D structure databases

ProteinModelPortali A9NDB3.
SMRi A9NDB3. Positions 13-183.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 360115.COXBURSA331_A1153.

Proteomic databases

PRIDEi A9NDB3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABX77366 ; ABX77366 ; COXBURSA331_A1153 .
GeneIDi 5793676.
KEGGi cbs:COXBURSA331_A1153.
PATRICi 17926568. VBICoxBur33747_1159.

Phylogenomic databases

eggNOGi COG0302.
HOGENOMi HOG000221222.
KOi K01495.
OMAi PRAYMER.
OrthoDBi EOG6XHC8G.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .
BioCyci CBUR360115:GI0X-1159-MONOMER.

Family and domain databases

HAMAPi MF_00223. FolE.
InterProi IPR001474. GTP_CycHdrlase_I.
IPR018234. GTP_CycHdrlase_I_CS.
IPR020602. GTP_CycHdrlase_I_dom.
[Graphical view ]
PANTHERi PTHR11109. PTHR11109. 1 hit.
Pfami PF01227. GTP_cyclohydroI. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00063. folE. 1 hit.
PROSITEi PS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
PS00860. GTP_CYCLOHYDROL_1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequencing of phylogenetically and phenotypically diverse Coxiella burnetii isolates."
    Seshadri R., Samuel J.E.
    Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RSA 331 / Henzerling II.

Entry informationi

Entry nameiGCH1_COXBR
AccessioniPrimary (citable) accession number: A9NDB3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: September 3, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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