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A9NCY5 (GLPK_COXBR) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 29. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glycerol kinase
EC=2.7.1.30
Alternative name(s):
ATP:glycerol 3-phosphotransferase
Glycerokinase
Short name=GK
Gene names
Name:glpK
Ordered Locus Names:COXBURSA331_A1011
OrganismCoxiella burnetii (strain RSA 331 / Henzerling II) [Complete proteome] [HAMAP]
Taxonomic identifier360115 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Legionellales › Coxiellaceae › Coxiella

Protein attributes

Sequence length501 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Key enzyme in the regulation of glycerol uptake and metabolism By similarity. HAMAP MF_00186

Catalytic activity

ATP + glycerol = ADP + sn-glycerol 3-phosphate. HAMAP MF_00186

Pathway

Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1. HAMAP MF_00186

Sequence similarities

Belongs to the FGGY kinase family.

Ontologies

Keywords
   Biological processGlycerol metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processglycerol-3-phosphate metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

glycerol kinase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 501501Glycerol kinase HAMAP MF_00186
PRO_1000077416

Regions

Nucleotide binding409 – 4135ATP By similarity

Sites

Binding site121Substrate By similarity
Binding site161ATP By similarity
Binding site821Substrate By similarity
Binding site1351Substrate By similarity
Binding site2441Substrate By similarity
Binding site2661ATP By similarity
Binding site3091ATP; via carbonyl oxygen By similarity

Sequences

Sequence LengthMass (Da)Tools
A9NCY5 [UniParc].

Last modified February 5, 2008. Version 1.
Checksum: 81AC7ACD01B95969

FASTA50155,359
        10         20         30         40         50         60 
MSSFILAIDQ GTTSTRAILF NEEAKLVHYH HVEITQYFPQ GGWVEHDPEE IWDSTLLCCR 

        70         80         90        100        110        120 
NVLEEASLRA ADIAALGISN QRETTILWDR HTGQPLYRAI GWQDRRTVNF CEQLASQAGV 

       130        140        150        160        170        180 
LAKFVEKTGL ILDPYFSCSK IKWILDNIKG AYEKAKRGEL AFGTVDSYLL WKFTGGKCHA 

       190        200        210        220        230        240 
TDATNASRTG LFNINQQRWD DELLTLFDIP KSLLPTVLDN CAQFGFTDLD LLGHKIPITA 

       250        260        270        280        290        300 
MIGDQQAAAV GQACIKPGMV KSTYGTGCFM LLNTGDQIIH SRNRLLATIA YRLNDTVTYG 

       310        320        330        340        350        360 
LEGSIFIAGA AVKWLRDPLH LIEKANDSES MASSVEDTGG VYLVPAFTGL GAPYWDPNAR 

       370        380        390        400        410        420 
GALFGLTRNT QREHIVRAAL EAVCYQSKDL VRAILNDGAN LTTLRVDGGM AANNWLLQFL 

       430        440        450        460        470        480 
SDILGVNVDR SRCIESSALG TAFLAGLGAG LFDSLEEMTG LWQADRHFIP QMDPKKQEEL 

       490        500 
YDGWQKAVEK TLTPAAPLLF P

« Hide

References

[1]"Genome sequencing of phylogenetically and phenotypically diverse Coxiella burnetii isolates."
Seshadri R., Samuel J.E.
Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: RSA 331 / Henzerling II.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000890 Genomic DNA. Translation: ABX77758.1.
RefSeqYP_001596775.1. NC_010117.1.

3D structure databases

ProteinModelPortalA9NCY5.
SMRA9NCY5. Positions 4-492.
ModBaseSearch...

Protein-protein interaction databases

STRINGA9NCY5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5793794.
GenomeReviewsGene locus glpK in contig CP000890_GR.
KEGGcbs:COXBURSA331_A1011.
PATRIC17926289. VBICoxBur33747_1020.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG511469.
OMACYQTRDL.
ProtClustDBCLSK914422.

Enzyme and pathway databases

BioCycCBUR360115:COXBURSA331_A1011-MONOMER.

Family and domain databases

HAMAPMF_00186. Glycerol_kin.
[Tree]
InterProIPR000577. Carb_kinase_FGGY.
IPR018485. Carb_kinase_FGGY_C.
IPR018483. Carb_kinase_FGGY_CS.
IPR018484. Carb_kinase_FGGY_N.
IPR005999. Glycerol_kin.
[Graphical view]
KOK00864.
PANTHERPTHR10196. FGGY_kin. 1 hit.
PTHR10196:SF9. Glycerol_kin. 1 hit.
PfamPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]
TIGRFAMsTIGR01311. Glycerol_kin. 1 hit.
PROSITEPS00933. FGGY_KINASES_1. 1 hit.
PS00445. FGGY_KINASES_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGLPK_COXBR
AccessionPrimary (citable) accession number: A9NCY5
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: January 25, 2012
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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