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A9NCA7

- LPXB_COXBR

UniProt

A9NCA7 - LPXB_COXBR

Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Coxiella burnetii (strain RSA 331 / Henzerling II)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 42 (01 Oct 2014)
      Sequence version 1 (05 Feb 2008)
      Previous versions | rss
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    Functioni

    Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

    Catalytic activityi

    UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid A biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciCBUR360115:GI0X-740-MONOMER.
    UniPathwayiUPA00359; UER00481.

    Protein family/group databases

    CAZyiGT19. Glycosyltransferase Family 19.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
    Gene namesi
    Name:lpxBUniRule annotation
    Ordered Locus Names:COXBURSA331_A0735
    OrganismiCoxiella burnetii (strain RSA 331 / Henzerling II)
    Taxonomic identifieri360115 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
    ProteomesiUP000008557: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 376376Lipid-A-disaccharide synthasePRO_1000080277Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi360115.COXBURSA331_A0735.

    Structurei

    3D structure databases

    ProteinModelPortaliA9NCA7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LpxB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0763.
    HOGENOMiHOG000018004.
    KOiK00748.
    OMAiLANIMFD.
    OrthoDBiEOG6FBWZR.

    Family and domain databases

    HAMAPiMF_00392. LpxB.
    InterProiIPR003835. Glyco_trans_19.
    [Graphical view]
    PfamiPF02684. LpxB. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00215. lpxB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A9NCA7-1 [UniParc]FASTAAdd to Basket

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    MSNKSVLLIA GEPSGDLLGA HLAQSLKSLE PNLKLAGMGG KRMREAGVEV    50
    FINADKLAVV GLLEILRQFR DIRHAMQTLK RYFKKTPPDL VVFIDYPGFN 100
    LHMAKQAKKA GIKVLYYVSP QIWAWRYGRI KKIKKYVDHM AVLFDFEEKL 150
    YQKENVPVSF VGHPLANAPT PSLSRNEICK QFNLDPDKPI VALFPGSREQ 200
    EINKLLPMMV QAGKLIQTQI PTVQFILPLA LNLALDKIRP FLSPEIKVIQ 250
    NDISYVLAIA HAAVAASGTV TLEIALQQVP LVIIYKVAPL TFWLGKKLIR 300
    LSFIGLCNLV SPEPVAVELL QQDATPQAIA DEVFQLLNNH NYRQSIIGKL 350
    GHLRPQLDRG NAAQNVAKVV HNLIFS 376
    Length:376
    Mass (Da):41,955
    Last modified:February 5, 2008 - v1
    Checksum:i6D1A160A53A58E7F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000890 Genomic DNA. Translation: ABX78484.1.
    RefSeqiWP_010957694.1. NC_010117.1.
    YP_001596547.1. NC_010117.1.

    Genome annotation databases

    EnsemblBacteriaiABX78484; ABX78484; COXBURSA331_A0735.
    GeneIDi5794660.
    KEGGicbs:COXBURSA331_A0735.
    PATRICi17925722. VBICoxBur33747_0751.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000890 Genomic DNA. Translation: ABX78484.1 .
    RefSeqi WP_010957694.1. NC_010117.1.
    YP_001596547.1. NC_010117.1.

    3D structure databases

    ProteinModelPortali A9NCA7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 360115.COXBURSA331_A0735.

    Protein family/group databases

    CAZyi GT19. Glycosyltransferase Family 19.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABX78484 ; ABX78484 ; COXBURSA331_A0735 .
    GeneIDi 5794660.
    KEGGi cbs:COXBURSA331_A0735.
    PATRICi 17925722. VBICoxBur33747_0751.

    Phylogenomic databases

    eggNOGi COG0763.
    HOGENOMi HOG000018004.
    KOi K00748.
    OMAi LANIMFD.
    OrthoDBi EOG6FBWZR.

    Enzyme and pathway databases

    UniPathwayi UPA00359 ; UER00481 .
    BioCyci CBUR360115:GI0X-740-MONOMER.

    Family and domain databases

    HAMAPi MF_00392. LpxB.
    InterProi IPR003835. Glyco_trans_19.
    [Graphical view ]
    Pfami PF02684. LpxB. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00215. lpxB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequencing of phylogenetically and phenotypically diverse Coxiella burnetii isolates."
      Seshadri R., Samuel J.E.
      Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RSA 331 / Henzerling II.

    Entry informationi

    Entry nameiLPXB_COXBR
    AccessioniPrimary (citable) accession number: A9NCA7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: February 5, 2008
    Last modified: October 1, 2014
    This is version 42 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3