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A9NC49

- SYL_COXBR

UniProt

A9NC49 - SYL_COXBR

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Protein

Leucine--tRNA ligase

Gene
leuS, COXBURSA331_A0673
Organism
Coxiella burnetii (strain RSA 331 / Henzerling II)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei579 – 5791ATP By similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCBUR360115:GI0X-678-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:COXBURSA331_A0673
OrganismiCoxiella burnetii (strain RSA 331 / Henzerling II)
Taxonomic identifieri360115 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
ProteomesiUP000008557: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 820820Leucine--tRNA ligaseUniRule annotationPRO_1000074830Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi360115.COXBURSA331_A0673.

Structurei

3D structure databases

ProteinModelPortaliA9NC49.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionUniRule annotationAdd
BLAST
Motifi576 – 5805"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiMAFAGPP.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9NC49-1 [UniParc]FASTAAdd to Basket

« Hide

MNESYQPTLI EQLAQEYWEE NETFEVKEDL SREKFYCLSM LPYPSGDLHM    50
GHVRNYTIGD VIARYQIHKG RNVLQPMGWD AFGLPAENAA IQRELPPAEW 100
TRKNIKKMRK QLKQLGFAYD WSREITTCDS TYYRWEQWLF LQLYKKGLAY 150
KKNAIVNWDP VDQTVLANEQ IVDGRGWRSG AVVERREISQ WFLKITDYSE 200
ELLKDLDELK EWPEQVITMQ RNWIGQSQGV IINFNFEKGP DKLQVYTTRP 250
DTLMGVTYLA IAPEHPLAKE RAKKSKKIAA FLKKCKQTRV AEADIATQEK 300
EGIDSGLFAV HPLSKEKLPI WIANFVLMEY ASGVVMAVPA HDERDHEFAL 350
KYDLPLKPVI EPADGHDWDY NQAAYTNPGK LINSGSFNDI DSKTAFNVIA 400
DYLKNNGAGS RQTHYRLRDW GISRQRYWGT PIPIIYCKTC GTVPVPENQL 450
PVLLPEDIIP TGHGSPLKET ASFYKTRCPV CNKPATRETD TMDTFVESSW 500
YYARYSCPDQ DKVMLDDRAK YWTPVDQYIG GIEHAVMHLL YARFMHKILR 550
DLGLLNSNEP FIRLLTQGMV LKDGAKMSKS KGNVVTPQSL IKKYGADTVR 600
LFIIFAAPPE QDLEWSDSGV EGAYRFLKKL WGFSYRIKDA LLAINQQKER 650
SNYQWEAPEH RQTRQQIHEC LQQANIDMER LQFNTVVSAV MKILNILIKL 700
TTDNDAEAHL IREGTGILLR LLSPITPHIS HHLWQSLGFG GDILDTPWPR 750
PDPKALQTTE LELIVQINGK LRGRIQVPTE ASKEIIESTA LNQENVQRHL 800
ADKKIKKVIV VPKKLINIVV 820
Length:820
Mass (Da):94,293
Last modified:February 5, 2008 - v1
Checksum:i1EF7E8BC8BECDE84
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000890 Genomic DNA. Translation: ABX78122.1.
RefSeqiWP_012220266.1. NC_010117.1.
YP_001596489.1. NC_010117.1.

Genome annotation databases

EnsemblBacteriaiABX78122; ABX78122; COXBURSA331_A0673.
GeneIDi5793291.
KEGGicbs:COXBURSA331_A0673.
PATRICi17925608. VBICoxBur33747_0694.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000890 Genomic DNA. Translation: ABX78122.1 .
RefSeqi WP_012220266.1. NC_010117.1.
YP_001596489.1. NC_010117.1.

3D structure databases

ProteinModelPortali A9NC49.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 360115.COXBURSA331_A0673.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABX78122 ; ABX78122 ; COXBURSA331_A0673 .
GeneIDi 5793291.
KEGGi cbs:COXBURSA331_A0673.
PATRICi 17925608. VBICoxBur33747_0694.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi MAFAGPP.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci CBUR360115:GI0X-678-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequencing of phylogenetically and phenotypically diverse Coxiella burnetii isolates."
    Seshadri R., Samuel J.E.
    Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RSA 331 / Henzerling II.

Entry informationi

Entry nameiSYL_COXBR
AccessioniPrimary (citable) accession number: A9NC49
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: September 3, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3