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A9NC49

- SYL_COXBR

UniProt

A9NC49 - SYL_COXBR

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Coxiella burnetii (strain RSA 331 / Henzerling II)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (05 Feb 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei579 – 5791ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCBUR360115:GI0X-678-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:COXBURSA331_A0673
    OrganismiCoxiella burnetii (strain RSA 331 / Henzerling II)
    Taxonomic identifieri360115 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
    ProteomesiUP000008557: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 820820Leucine--tRNA ligasePRO_1000074830Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi360115.COXBURSA331_A0673.

    Structurei

    3D structure databases

    ProteinModelPortaliA9NC49.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi42 – 5211"HIGH" regionAdd
    BLAST
    Motifi576 – 5805"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiMAFAGPP.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A9NC49-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNESYQPTLI EQLAQEYWEE NETFEVKEDL SREKFYCLSM LPYPSGDLHM    50
    GHVRNYTIGD VIARYQIHKG RNVLQPMGWD AFGLPAENAA IQRELPPAEW 100
    TRKNIKKMRK QLKQLGFAYD WSREITTCDS TYYRWEQWLF LQLYKKGLAY 150
    KKNAIVNWDP VDQTVLANEQ IVDGRGWRSG AVVERREISQ WFLKITDYSE 200
    ELLKDLDELK EWPEQVITMQ RNWIGQSQGV IINFNFEKGP DKLQVYTTRP 250
    DTLMGVTYLA IAPEHPLAKE RAKKSKKIAA FLKKCKQTRV AEADIATQEK 300
    EGIDSGLFAV HPLSKEKLPI WIANFVLMEY ASGVVMAVPA HDERDHEFAL 350
    KYDLPLKPVI EPADGHDWDY NQAAYTNPGK LINSGSFNDI DSKTAFNVIA 400
    DYLKNNGAGS RQTHYRLRDW GISRQRYWGT PIPIIYCKTC GTVPVPENQL 450
    PVLLPEDIIP TGHGSPLKET ASFYKTRCPV CNKPATRETD TMDTFVESSW 500
    YYARYSCPDQ DKVMLDDRAK YWTPVDQYIG GIEHAVMHLL YARFMHKILR 550
    DLGLLNSNEP FIRLLTQGMV LKDGAKMSKS KGNVVTPQSL IKKYGADTVR 600
    LFIIFAAPPE QDLEWSDSGV EGAYRFLKKL WGFSYRIKDA LLAINQQKER 650
    SNYQWEAPEH RQTRQQIHEC LQQANIDMER LQFNTVVSAV MKILNILIKL 700
    TTDNDAEAHL IREGTGILLR LLSPITPHIS HHLWQSLGFG GDILDTPWPR 750
    PDPKALQTTE LELIVQINGK LRGRIQVPTE ASKEIIESTA LNQENVQRHL 800
    ADKKIKKVIV VPKKLINIVV 820
    Length:820
    Mass (Da):94,293
    Last modified:February 5, 2008 - v1
    Checksum:i1EF7E8BC8BECDE84
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000890 Genomic DNA. Translation: ABX78122.1.
    RefSeqiWP_012220266.1. NC_010117.1.
    YP_001596489.1. NC_010117.1.

    Genome annotation databases

    EnsemblBacteriaiABX78122; ABX78122; COXBURSA331_A0673.
    GeneIDi5793291.
    KEGGicbs:COXBURSA331_A0673.
    PATRICi17925608. VBICoxBur33747_0694.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000890 Genomic DNA. Translation: ABX78122.1 .
    RefSeqi WP_012220266.1. NC_010117.1.
    YP_001596489.1. NC_010117.1.

    3D structure databases

    ProteinModelPortali A9NC49.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 360115.COXBURSA331_A0673.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABX78122 ; ABX78122 ; COXBURSA331_A0673 .
    GeneIDi 5793291.
    KEGGi cbs:COXBURSA331_A0673.
    PATRICi 17925608. VBICoxBur33747_0694.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi MAFAGPP.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci CBUR360115:GI0X-678-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequencing of phylogenetically and phenotypically diverse Coxiella burnetii isolates."
      Seshadri R., Samuel J.E.
      Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RSA 331 / Henzerling II.

    Entry informationi

    Entry nameiSYL_COXBR
    AccessioniPrimary (citable) accession number: A9NC49
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: February 5, 2008
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3