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A9NC23

- PYRF_COXBR

UniProt

A9NC23 - PYRF_COXBR

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Protein
Orotidine 5'-phosphate decarboxylase
Gene
pyrF, COXBURSA331_A0645
Organism
Coxiella burnetii (strain RSA 331 / Henzerling II)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP) By similarity.UniRule annotation

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei13 – 131Substrate By similarity
Binding sitei35 – 351Substrate By similarity
Active sitei64 – 641Proton donor By similarity
Binding sitei123 – 1231Substrate By similarity
Binding sitei184 – 1841Substrate By similarity
Binding sitei193 – 1931Substrate By similarity
Binding sitei213 – 2131Substrate; via amide nitrogen By similarity
Binding sitei214 – 2141Substrate By similarity

GO - Molecular functioni

  1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
  2. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

BioCyciCBUR360115:GI0X-650-MONOMER.
UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
Alternative name(s):
OMP decarboxylase
Short name:
OMPDCase
Short name:
OMPdecase
Gene namesi
Name:pyrF
Ordered Locus Names:COXBURSA331_A0645
OrganismiCoxiella burnetii (strain RSA 331 / Henzerling II)
Taxonomic identifieri360115 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
ProteomesiUP000008557: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 236236Orotidine 5'-phosphate decarboxylaseUniRule annotation
PRO_1000085489Add
BLAST

Proteomic databases

PRIDEiA9NC23.

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi360115.COXBURSA331_A0645.

Structurei

3D structure databases

ProteinModelPortaliA9NC23.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni62 – 7110Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0284.
HOGENOMiHOG000226071.
KOiK01591.
OMAiRPITQSA.
OrthoDBiEOG6N6815.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01200_B. OMPdecase_type1_B.
InterProiIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR01740. pyrF. 1 hit.
PROSITEiPS00156. OMPDECASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9NC23-1 [UniParc]FASTAAdd to Basket

« Hide

MEKPDPKVIV AIDAGTVEQA RAQINPLTPE LCHLKIGSIL FTRYGPAFVE    50
ELMQKGYRIF LDLKFYDIPQ TVAGACRAVA ELGVWMMNIH ISGGRTMMET 100
VVNALQSITL KEKPLLIGVT ILTSLDGSDL KTLGIQEKVP DIVCRMATLA 150
KSAGLDGVVC SAQEAALLRK QFDRNFLLVT PGIRLETDEK GDQKRVMTPR 200
AAIQAGSDYL VIGRPITQST DPLKALEAID KDIKTR 236
Length:236
Mass (Da):25,849
Last modified:February 5, 2008 - v1
Checksum:i6299A5996F538ECA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000890 Genomic DNA. Translation: ABX78819.1.
RefSeqiYP_001596463.1. NC_010117.1.

Genome annotation databases

EnsemblBacteriaiABX78819; ABX78819; COXBURSA331_A0645.
GeneIDi5793498.
KEGGicbs:COXBURSA331_A0645.
PATRICi17925549. VBICoxBur33747_0665.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000890 Genomic DNA. Translation: ABX78819.1 .
RefSeqi YP_001596463.1. NC_010117.1.

3D structure databases

ProteinModelPortali A9NC23.
ModBasei Search...

Protein-protein interaction databases

STRINGi 360115.COXBURSA331_A0645.

Proteomic databases

PRIDEi A9NC23.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABX78819 ; ABX78819 ; COXBURSA331_A0645 .
GeneIDi 5793498.
KEGGi cbs:COXBURSA331_A0645.
PATRICi 17925549. VBICoxBur33747_0665.

Phylogenomic databases

eggNOGi COG0284.
HOGENOMi HOG000226071.
KOi K01591.
OMAi RPITQSA.
OrthoDBi EOG6N6815.

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00120 .
BioCyci CBUR360115:GI0X-650-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01200_B. OMPdecase_type1_B.
InterProi IPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00215. OMPdecase. 1 hit.
[Graphical view ]
SMARTi SM00934. OMPdecase. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR01740. pyrF. 1 hit.
PROSITEi PS00156. OMPDECASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequencing of phylogenetically and phenotypically diverse Coxiella burnetii isolates."
    Seshadri R., Samuel J.E.
    Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RSA 331 / Henzerling II.

Entry informationi

Entry nameiPYRF_COXBR
AccessioniPrimary (citable) accession number: A9NC23
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: May 14, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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