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Protein

Phosphoenolpyruvate carboxykinase [ATP]

Gene

pckA

Organism
Coxiella burnetii (strain RSA 331 / Henzerling II)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.UniRule annotation

Catalytic activityi

ATP + oxaloacetate = ADP + phosphoenolpyruvate + CO2.UniRule annotation

Cofactori

Mn2+UniRule annotationNote: Binds 1 Mn2+ ion per subunit.UniRule annotation

Pathwayi: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei46SubstrateUniRule annotation1
Binding sitei180SubstrateUniRule annotation1
Metal bindingi186ManganeseUniRule annotation1
Binding sitei186ATPUniRule annotation1
Binding sitei186SubstrateUniRule annotation1
Metal bindingi205Manganese; via tele nitrogenUniRule annotation1
Binding sitei205ATPUniRule annotation1
Metal bindingi242ManganeseUniRule annotation1
Binding sitei270ATPUniRule annotation1
Binding sitei306ATPUniRule annotation1
Binding sitei306SubstrateUniRule annotation1
Binding sitei433ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi221 – 229ATPUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Gluconeogenesis

Keywords - Ligandi

ATP-binding, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxykinase [ATP]UniRule annotation (EC:4.1.1.49UniRule annotation)
Short name:
PCKUniRule annotation
Short name:
PEP carboxykinaseUniRule annotation
Short name:
PEPCKUniRule annotation
Gene namesi
Name:pckAUniRule annotation
Ordered Locus Names:COXBURSA331_A2217
OrganismiCoxiella burnetii (strain RSA 331 / Henzerling II)
Taxonomic identifieri360115 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000809931 – 517Phosphoenolpyruvate carboxykinase [ATP]Add BLAST517

Interactioni

Subunit structurei

Monomer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA9NBT9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the phosphoenolpyruvate carboxykinase [ATP] family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000271471.
KOiK01610.
OMAiRFIVKEP.

Family and domain databases

CDDicd00484. PEPCK_ATP. 1 hit.
Gene3Di3.40.449.10. 1 hit.
3.90.228.20. 2 hits.
HAMAPiMF_00453. PEPCK_ATP. 1 hit.
InterProiIPR001272. PEP_carboxykinase_ATP.
IPR013035. PEP_carboxykinase_C.
IPR008210. PEP_carboxykinase_N.
IPR015994. PEPCK_ATP_CS.
[Graphical view]
PfamiPF01293. PEPCK_ATP. 1 hit.
[Graphical view]
PIRSFiPIRSF006294. PEP_crbxkin. 1 hit.
SUPFAMiSSF68923. SSF68923. 1 hit.
TIGRFAMsiTIGR00224. pckA. 1 hit.
PROSITEiPS00532. PEPCK_ATP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9NBT9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQIAARVTY INLSPDELIQ HAVKNGEGVL SSTGALAVTT GKRTGRSPKD
60 70 80 90 100
RFIVKDEQTA DQVAWGNINQ PVEQRTFDQL WERALRYLSE RAVYISHLQV
110 120 130 140 150
GADDNYFLPL KVVTEFAWHN LFACDLFIRP SGDHANGKPS WVILSAPGLK
160 170 180 190 200
TDPERDGVNS DGAVMINLSQ RRVLLVGMPY AGEMKKAMFS VLNYLLPPHD
210 220 230 240 250
VLPMHCAANA GQSGDVALFF GLSGTGKTTL SADPHRFLIG DDEHGWSATS
260 270 280 290 300
VFNFEGGCYA KCIDLSQERE PMIWNAIRHG AIMENVVLDE NGVPDYADAR
310 320 330 340 350
LTQNSRAAYP REYIPLRVEN NRGRPPDAVL FLTCDLDGVL PPVALLTKEQ
360 370 380 390 400
AAYYFLSGYT ALVGSTEVGS VKGVTSTFST CFGAPFFPRP PTVYAELLMK
410 420 430 440 450
RIEATGCQVY LVNTGWTGGA YGEGGERFSI PTTRAIVNAV LSGKLKEGPT
460 470 480 490 500
EVLSGFNLTI PKSALGVDDH LLNPRKTWED VSAYDARAQR LIQKFRENFE
510
KFKVLAAIRE AGPSDVH
Length:517
Mass (Da):56,807
Last modified:February 5, 2008 - v1
Checksum:i46B9BB2DBFC1CCC6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000890 Genomic DNA. Translation: ABX78495.1.
RefSeqiWP_010958647.1. NC_010117.1.

Genome annotation databases

EnsemblBacteriaiABX78495; ABX78495; COXBURSA331_A2217.
KEGGicbs:COXBURSA331_A2217.
PATRICi17928666. VBICoxBur33747_2190.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000890 Genomic DNA. Translation: ABX78495.1.
RefSeqiWP_010958647.1. NC_010117.1.

3D structure databases

ProteinModelPortaliA9NBT9.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABX78495; ABX78495; COXBURSA331_A2217.
KEGGicbs:COXBURSA331_A2217.
PATRICi17928666. VBICoxBur33747_2190.

Phylogenomic databases

HOGENOMiHOG000271471.
KOiK01610.
OMAiRFIVKEP.

Enzyme and pathway databases

UniPathwayiUPA00138.

Family and domain databases

CDDicd00484. PEPCK_ATP. 1 hit.
Gene3Di3.40.449.10. 1 hit.
3.90.228.20. 2 hits.
HAMAPiMF_00453. PEPCK_ATP. 1 hit.
InterProiIPR001272. PEP_carboxykinase_ATP.
IPR013035. PEP_carboxykinase_C.
IPR008210. PEP_carboxykinase_N.
IPR015994. PEPCK_ATP_CS.
[Graphical view]
PfamiPF01293. PEPCK_ATP. 1 hit.
[Graphical view]
PIRSFiPIRSF006294. PEP_crbxkin. 1 hit.
SUPFAMiSSF68923. SSF68923. 1 hit.
TIGRFAMsiTIGR00224. pckA. 1 hit.
PROSITEiPS00532. PEPCK_ATP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPCKA_COXBR
AccessioniPrimary (citable) accession number: A9NBT9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: November 2, 2016
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.