Reviewed, UniProtKB/Swiss-Prot A9NB80 (AROK_COXBR)

Names and origin

Protein names

Recommended name:
    Shikimate kinase
      Short name=SK
    EC=2.7.1.71

Gene names

Name:	aroK
Ordered Locus Names:	COXBURSA331_A2097

Organism

Coxiella burnetii (strain RSA 331 / Henzerling II) [Complete proteome] [HAMAP]

Taxonomic identifier

360115 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Legionellales › Coxiellaceae › Coxiella

Protein attributes

Sequence length	179 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate By similarity.
Catalytic activity	ATP + shikimate = ADP + shikimate 3-phosphate. HAMAP MF_00109
Cofactor	Binds 1 magnesium ion per subunit By similarity.
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and PEP: step 5/7. HAMAP MF_00109
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the shikimate kinase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP magnesium ion binding Inferred from electronic annotation. Source: HAMAP shikimate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 179	179	Shikimate kinase HAMAP MF_00109		PRO_1000075948
Regions
	Nucleotide binding	15 – 20	6	ATP By similarity
Sites
	Metal binding	19	1	Magnesium By similarity
	Binding site	37	1	Substrate By similarity
	Binding site	61	1	Substrate By similarity
	Binding site	83	1	Substrate; via amide nitrogen By similarity
	Binding site	122	1	ATP By similarity
	Binding site	142	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	A9NB80-1 [UniParc]. Last modified February 5, 2008. Version 1. Checksum: 9F163BB054582F74	FASTA	179	20,336
	10 20 30 40 50 60 MKKDLTNIYL IGLMGAGKTS VGSQLAKLTK RILYDSDKEI EKRTGADIAW IFEMEGEAGF 70 80 90 100 110 120 RRREREMIEA LCKLDNIILA TGGGVVLDEK NRQQISETGV VIYLTASIDT QLKRIGQKGE 130 140 150 160 170 MRRPLFIKNN SKEKLQQLNE IRKPLYQAMA DLVYPTDDLN PRQLATQILV DIKQTYSDL

References

[1]	"Genome sequencing of phylogenetically and phenotypically diverse Coxiella burnetii isolates." Seshadri R., Samuel J.E. Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000890 Genomic DNA. Translation: ABX78282.1.
RefSeq	YP_001597711.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5794129.
GenomeReviews	Gene locus aroK in contig CP000890_GR.
KEGG	cbs:COXBURSA331_A2097.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	A9NB80. HANVFFV.
Family and domain databases
HAMAP	MF_00109. [Tree]
InterPro	IPR000623. Shik_kinase. [Graphical view]
Pfam	PF01202. SKI. 1 hit. [Graphical view]
PRINTS	PR01100. SHIKIMTKNASE.
PROSITE	PS01128. SHIKIMATE_KINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROK_COXBR

Accession

Primary (citable) accession number: A9NB80

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	February 5, 2008
Last modified:	June 16, 2009
This is version 12 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)