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A9NAH9 (A9NAH9_COXBR) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Tyrosine--tRNA ligase HAMAP-Rule MF_02007
EC=6.1.1.1 HAMAP-Rule MF_02007
Alternative name(s):
Tyrosyl-tRNA synthetase HAMAP-Rule MF_02007
Gene names
Name:tyrS HAMAP-Rule MF_02007 EMBL ABX78578.1
Ordered Locus Names:COXBURSA331_A0271 EMBL ABX78578.1
OrganismCoxiella burnetii (strain RSA 331 / Henzerling II) [Complete proteome] [HAMAP] EMBL ABX78578.1
Taxonomic identifier360115 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Legionellales › Coxiellaceae › Coxiella ›

Protein attributes

Sequence length399 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr) By similarity. HAMAP-Rule MF_02007 SAAS SAAS002307

Catalytic activity

ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + L-tyrosyl-tRNA(Tyr). HAMAP-Rule MF_02007 SAAS SAAS002307

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_02007 SAAS SAAS002307

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_02007.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily. HAMAP-Rule MF_02007

Contains 1 S4 RNA-binding domain. HAMAP-Rule MF_02007 SAAS SAAS002307

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain337 – 39862S4 RNA-binding By similarity HAMAP-Rule MF_02007
Motif42 – 5110"HIGH" region By similarity HAMAP-Rule MF_02007
Motif226 – 2305"KMSKS" region By similarity HAMAP-Rule MF_02007

Sites

Binding site2291ATP By similarity HAMAP-Rule MF_02007

Sequences

Sequence LengthMass (Da)Tools
A9NAH9 [UniParc].

Last modified February 5, 2008. Version 1.
Checksum: E1DE9D0A80063B01

FASTA39945,777
        10         20         30         40         50         60 
MISSQEAFEE IKRGAVEIIH EDELLSRLAE EKPLRIKLGF DPTAPDIHLG HTVVLNKLRQ 

        70         80         90        100        110        120 
FQTLGHEVIF LIGDFTAMIG DPTGKNITRQ PLTCEIVMEN TKTYETQAFR ILDPDKTQVT 

       130        140        150        160        170        180 
SNSTWINKLK ADDLVRLAAT YTVARMLERD DFNKRYLSQQ PIAIHEFLYP LLQGYDSVAL 

       190        200        210        220        230        240 
KADVELGGTD QKFNLLVGRE LQKHFGQRPQ CVLTVPLLEG LDGIQKMSKS LNNYIGITEP 

       250        260        270        280        290        300 
PEEMFGKVMS ISDELMWRYY ELLSFRPMRE INRWREEVSE GRNPRDIKIL LAEELVTRFH 

       310        320        330        340        350        360 
SKEAATKAHQ HFIDRFKRHE LPTDLDEIEL TAENTHLTIG YILQRAGLVN TTSEGLRMIA 

       370        380        390 
QGAVRIDGER VEDIKLAIPR GESHLFQVGK RRFAKVKVI

« Hide

References

[1]"Genome sequencing of phylogenetically and phenotypically diverse Coxiella burnetii isolates."
Seshadri R., Samuel J.E.
Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: RSA 331 / Henzerling II.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000890 Genomic DNA. Translation: ABX78578.1.
RefSeqYP_001596140.1. NC_010117.1.

3D structure databases

ProteinModelPortalA9NAH9.
ModBaseSearch...

Protein-protein interaction databases

STRING360115.COXBURSA331_A0271.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABX78578; ABX78578; COXBURSA331_A0271.
GeneID5794525.
KEGGcbs:COXBURSA331_A0271.
PATRIC17924810. VBICoxBur33747_0311.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0162.
HOGENOMHOG000242791.
KOK01866.
OMAGGNDQKF.
ProtClustDBPRK05912.

Enzyme and pathway databases

BioCycCBUR360115:GI0X-316-MONOMER.

Family and domain databases

Gene3D3.10.290.10. 1 hit.
3.40.50.620. 1 hit.
HAMAPMF_02007. Tyr_tRNA_synth_type2.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002942. S4_RNA-bd.
IPR002307. Tyr-tRNA-ligase.
IPR024088. Tyr-tRNA-ligase_bac-type.
IPR024108. Tyr-tRNA-ligase_bac_2.
[Graphical view]
PANTHERPTHR11766. PTHR11766. 1 hit.
PfamPF01479. S4. 1 hit.
PF00579. tRNA-synt_1b. 1 hit.
[Graphical view]
PRINTSPR01040. TRNASYNTHTYR.
SMARTSM00363. S4. 1 hit.
[Graphical view]
TIGRFAMsTIGR00234. tyrS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
PS50889. S4. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA9NAH9_COXBR
AccessionPrimary (citable) accession number: A9NAH9
Entry history
Integrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: May 1, 2013
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info