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A9NA98

- PUR5_COXBR

UniProt

A9NA98 - PUR5_COXBR

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Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene
purM, COXBURSA331_A1928
Organism
Coxiella burnetii (strain RSA 331 / Henzerling II)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCBUR360115:GI0X-1933-MONOMER.
UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligase (EC:6.3.3.1)
Alternative name(s):
AIR synthase
AIRS
Phosphoribosyl-aminoimidazole synthetase
Gene namesi
Name:purM
Ordered Locus Names:COXBURSA331_A1928
OrganismiCoxiella burnetii (strain RSA 331 / Henzerling II)
Taxonomic identifieri360115 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
ProteomesiUP000008557: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 352352Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotationPRO_1000083456Add
BLAST

Proteomic databases

PRIDEiA9NA98.

Interactioni

Protein-protein interaction databases

STRINGi360115.COXBURSA331_A1928.

Structurei

3D structure databases

ProteinModelPortaliA9NA98.
SMRiA9NA98. Positions 13-350.

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.

Phylogenomic databases

eggNOGiCOG0150.
HOGENOMiHOG000229091.
KOiK01933.
OMAiEFEMYRT.
OrthoDBiEOG61CM1V.

Family and domain databases

Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741_B. AIRS_B.
InterProiIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

A9NA98-1 [UniParc]FASTAAdd to Basket

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MQSMPDSTRH PPLSYCKAGV DIEKAADLVE AIKPIAKRTR RPGVLSGIGG    50
FGGLFELPRG YKQPVLVSGT DGVGTKLKLA VELNRHDTIG IDLVAMCVND 100
VITTGAEPLF FLDYYATGHL NNEQAKQILT GIGAGCELAE VALIGGETAE 150
MPGLYRQKDY DLAGFCVGVV EKEKIIDGSR VRVGDALIGI ASSGPHSNGY 200
SLIRKILARA KIPLSQSFEN KSLADGLLAP TRIYVKTIKR LFSEINVHAL 250
AHITGGGLIE NVPRVLPSYT QAVIDSNGWE WPAIFHWLQK QGKVPIEEMW 300
RTFNMGVGMV LCLDKKEVRK TLELLAALGE TAWILGEIQS SSEEQPRVTI 350
TP 352
Length:352
Mass (Da):38,216
Last modified:February 5, 2008 - v1
Checksum:i63AE5DF66FD546EA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000890 Genomic DNA. Translation: ABX77697.1.
RefSeqiWP_012220774.1. NC_010117.1.
YP_001597557.1. NC_010117.1.

Genome annotation databases

EnsemblBacteriaiABX77697; ABX77697; COXBURSA331_A1928.
GeneIDi5793030.
KEGGicbs:COXBURSA331_A1928.
PATRICi17928106. VBICoxBur33747_1912.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000890 Genomic DNA. Translation: ABX77697.1 .
RefSeqi WP_012220774.1. NC_010117.1.
YP_001597557.1. NC_010117.1.

3D structure databases

ProteinModelPortali A9NA98.
SMRi A9NA98. Positions 13-350.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 360115.COXBURSA331_A1928.

Proteomic databases

PRIDEi A9NA98.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABX77697 ; ABX77697 ; COXBURSA331_A1928 .
GeneIDi 5793030.
KEGGi cbs:COXBURSA331_A1928.
PATRICi 17928106. VBICoxBur33747_1912.

Phylogenomic databases

eggNOGi COG0150.
HOGENOMi HOG000229091.
KOi K01933.
OMAi EFEMYRT.
OrthoDBi EOG61CM1V.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00129 .
BioCyci CBUR360115:GI0X-1933-MONOMER.

Family and domain databases

Gene3Di 3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPi MF_00741_B. AIRS_B.
InterProi IPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view ]
Pfami PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view ]
SUPFAMi SSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsi TIGR00878. purM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequencing of phylogenetically and phenotypically diverse Coxiella burnetii isolates."
    Seshadri R., Samuel J.E.
    Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RSA 331 / Henzerling II.

Entry informationi

Entry nameiPUR5_COXBR
AccessioniPrimary (citable) accession number: A9NA98
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: September 3, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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