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A9NA98 (PUR5_COXBR) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoribosylformylglycinamidine cyclo-ligase

EC=6.3.3.1
Alternative name(s):
AIR synthase
AIRS
Phosphoribosyl-aminoimidazole synthetase
Gene names
Name:purM
Ordered Locus Names:COXBURSA331_A1928
OrganismCoxiella burnetii (strain RSA 331 / Henzerling II) [Complete proteome] [HAMAP]
Taxonomic identifier360115 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella

Protein attributes

Sequence length352 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole. HAMAP-Rule MF_00741

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2. HAMAP-Rule MF_00741

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00741.

Sequence similarities

Belongs to the AIR synthase family.

Ontologies

Keywords
   Biological processPurine biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_process'de novo' IMP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoribosylformylglycinamidine cyclo-ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 352352Phosphoribosylformylglycinamidine cyclo-ligase HAMAP-Rule MF_00741
PRO_1000083456

Sequences

Sequence LengthMass (Da)Tools
A9NA98 [UniParc].

Last modified February 5, 2008. Version 1.
Checksum: 63AE5DF66FD546EA

FASTA35238,216
        10         20         30         40         50         60 
MQSMPDSTRH PPLSYCKAGV DIEKAADLVE AIKPIAKRTR RPGVLSGIGG FGGLFELPRG 

        70         80         90        100        110        120 
YKQPVLVSGT DGVGTKLKLA VELNRHDTIG IDLVAMCVND VITTGAEPLF FLDYYATGHL 

       130        140        150        160        170        180 
NNEQAKQILT GIGAGCELAE VALIGGETAE MPGLYRQKDY DLAGFCVGVV EKEKIIDGSR 

       190        200        210        220        230        240 
VRVGDALIGI ASSGPHSNGY SLIRKILARA KIPLSQSFEN KSLADGLLAP TRIYVKTIKR 

       250        260        270        280        290        300 
LFSEINVHAL AHITGGGLIE NVPRVLPSYT QAVIDSNGWE WPAIFHWLQK QGKVPIEEMW 

       310        320        330        340        350 
RTFNMGVGMV LCLDKKEVRK TLELLAALGE TAWILGEIQS SSEEQPRVTI TP 

« Hide

References

[1]"Genome sequencing of phylogenetically and phenotypically diverse Coxiella burnetii isolates."
Seshadri R., Samuel J.E.
Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: RSA 331 / Henzerling II.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000890 Genomic DNA. Translation: ABX77697.1.
RefSeqYP_001597557.1. NC_010117.1.

3D structure databases

ProteinModelPortalA9NA98.
SMRA9NA98. Positions 13-350.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING360115.COXBURSA331_A1928.

Proteomic databases

PRIDEA9NA98.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABX77697; ABX77697; COXBURSA331_A1928.
GeneID5793030.
KEGGcbs:COXBURSA331_A1928.
PATRIC17928106. VBICoxBur33747_1912.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0150.
HOGENOMHOG000229091.
KOK01933.
OMAHCVNDIL.
OrthoDBEOG61CM1V.
ProtClustDBPRK05385.

Enzyme and pathway databases

BioCycCBUR360115:GI0X-1933-MONOMER.
UniPathwayUPA00074; UER00129.

Family and domain databases

Gene3D3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPMF_00741_B. AIRS_B.
InterProIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsTIGR00878. purM. 1 hit.
ProtoNetSearch...

Entry information

Entry namePUR5_COXBR
AccessionPrimary (citable) accession number: A9NA98
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: April 16, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways